Ultra low dose aerosol challenge with Mycobacterium tuberculosis leads to divergent outcomes in rhesus and cynomolgus macaques

Tuberculosis

Volumn 96, Issue , 2016, Pages 1-12

  Sharpe, Sally ^a   White, Andrew ^a   Gleeson, Fergus ^b   McIntyre, Anthony ^b   Smyth, Donna ^a   Clark, Simon ^a   Sarfas, Charlotte ^a   Laddy, Dominick ^c   Rayner, Emma ^a   Hall, Graham ^a   Williams, Ann ^a   Dennis, Mike ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c AERAS   (United States)

Author keywords

Aerosol challenge; Low dose; Non human primate; Tuberculosis

Indexed keywords

BCG VACCINE; AEROSOL;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLONY FORMING UNIT; COMPUTER ASSISTED TOMOGRAPHY; DISEASE COURSE; DRUG EFFICACY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; IN VIVO STUDY; LUNG; MALE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TUBERCULOSIS; ANIMAL; BACTERIAL COUNT; BACTERIAL LOAD; BIOPSY; COMPARATIVE STUDY; DIAGNOSTIC IMAGING; DISEASE MODEL; EXPOSURE; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; IMMUNOLOGY; LUNG TUBERCULOSIS; MACACA FASCICULARIS; MICROBIOLOGY; PATHOLOGY; RHESUS MONKEY; SPECIES DIFFERENCE; TIME FACTOR; X-RAY COMPUTED TOMOGRAPHY;

AEROSOLS; ANIMALS; BACTERIAL LOAD; BIOPSY; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; HOST-PATHOGEN INTERACTIONS; INHALATION EXPOSURE; LUNG; MACACA FASCICULARIS; MACACA MULATTA; MALE; MYCOBACTERIUM TUBERCULOSIS; SPECIES SPECIFICITY; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; TUBERCULOSIS, PULMONARY;

EID: 84954431604     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/j.tube.2015.10.004     Document Type: Article

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