Epidemiology and antimicrobial susceptibilities of wound isolates of obligate anaerobes from combat casualties

Diagnostic Microbiology and Infectious Disease

Volumn 84, Issue 2, 2016, Pages 144-150

  White, Brian K ^a   Mende, Katrin ^a,b,c   Weintrob, Amy C ^b,c,d,f   Beckius, Miriam L ^a   Zera, Wendy C ^a,b,c   Lu, Dan ^b,c   Bradley, William ^a,b,c   Tribble, David R ^b   Schnaubelt, Elizabeth R ^e   Murray, Clinton K ^a  

^a SAN ANTONIO MILITARY MEDICAL CENTER   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

^d WALTER REED ARMY MEDICAL CENTER   (United States)

^e LANDSTUHL REGIONAL MEDICAL CENTER   (Germany)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Anaerobes; Antimicrobial susceptibility; Trauma related infections; War wounds

Indexed keywords

CEFOXITIN; CLINDAMYCIN; ERTAPENEM; IMIPENEM; LINEZOLID; MEROPENEM; METRONIDAZOLE; MOXIFLOXACIN; PIPERACILLIN PLUS TAZOBACTAM; SULTAMICILLIN; TIGECYCLINE; ANTIINFECTIVE AGENT;

ADULT; ANAEROBIC BACTERIUM; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; BACTEROIDES; BACTEROIDES FRAGILIS; BATTLE INJURY; CAUSAL ATTRIBUTION; CLOSTRIDIUM; DRUG EXPOSURE; FINEGOLDIA; HUMAN; LEG INJURY; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTOSTREPTOCOCCUS; PREVOTELLA; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES; AFGHANISTAN; BACTERIAL INFECTIONS; CLASSIFICATION; COMPLICATION; DRUG EFFECTS; INJURY; IRAQ; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; TREATMENT OUTCOME; WARFARE; WOUND INFECTION; YOUNG ADULT;

ADULT; AFGHANISTAN; ANTI-BACTERIAL AGENTS; BACTERIA, ANAEROBIC; BACTERIAL INFECTIONS; DRUG RESISTANCE, BACTERIAL; HUMANS; IRAQ; MALE; MICROBIAL SENSITIVITY TESTS; TREATMENT OUTCOME; WARFARE; WOUND INFECTION; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 84954375589     PISSN: 07328893     EISSN: 18790070     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2015.10.010     Document Type: Article

References (43)

1. Ali M.H., Hoekzema N.A., Bakleh M., Shin A.Y., Osmon D.R. The microbiology and risk of infection following open, agricultural upper extremity injuries. J Hand Surg [Am] 2008, 33:87-93. 10.1016/j.jhsa.2007.09.003.
2. Ani C., Farshidpanah S., Bellinghausen Stewart A., Nguyen H.B. Variations in organism-specific severe sepsis mortality in the United States: 1999-2008. Crit Care Med 2015, 43:65-77. 10.1097/CCM.0000000000000555.
3. Be N.A., Allen J.E., Brown T.S., Gardner S.N., McLoughlin K.S., Forsberg J.A., et al. Microbial profiling of combat wound infection through detection microarray and next-generation sequencing. J Clin Microbiol 2014, 52:2583-2594. 10.1128/JCM.00556-14.
4. Blyth D.M., Mende K., Weintrob A.C., Beckius M.L., Zera W.C., Bradley W., et al. Resistance patterns and clinical significance of Candida colonization and infection in combat-related injured patients from Iraq and Afghanistan. Open Forum Infect Dis 2014, 1. (ofu109). 10.1093/ofid/ofu109.
5. Bowler P.G., Duerden B.I., Armstrong D.G. Wound microbiology and associated approaches to wound management. Clin Microbiol Rev 2001, 14:244-269.
6. Brook I., Frazier E.H. Aerobic and anaerobic microbiology of infection after trauma. Am J Emerg Med 1998, 16:585-591.
7. Brook I., Wexler H.M., Goldstein E.J. Antianaerobic antimicrobials: spectrum and susceptibility testing. Clin Microbiol Rev 2013, 26:526-546. 10.1128/CMR.00086-12.
8. Calhoun J.H., Murray C.K., Manring M.M. Multidrug-resistant organisms in military wounds from Iraq and Afghanistan. Clin Orthop Relat Res 2008, 466:1356-1362. 10.1007/s11999-008-0212-9.
9. Clinical and Laboratory Standards Institute Methods for antimicrobial susceptibility testing of anaerobic bacteria; approved standard. CLSI document M11-A8 2012, (Wayne, PA).
10. Dau A.A., Tloba S., Daw M.A. Characterization of wound infections among patients injured during the 2011 Libyan conflict. East Mediterr Health J 2013, 19:356-361.
11. de Carvalho C.B., Moreira J.L., Ferreira M.C. Epidemiology and antimicrobial resistance of B. fragilis group organisms isolated from clinical specimen and human intestinal microbiota. Rev Inst Med Trop Sao Paulo 1996, 38:329-335.
12. Fleming A. On the bacteriology of septic wounds. Lancet 1915, 2:638-643.
13. Hawser S.P. Activity of tigecycline against multidrug-resistant clinical isolates of Clostridium spp. from Europe. Int J Antimicrob Agents 2010, 35:310-311. 10.1016/j.ijantimicag.2009.11.006.
14. Hecht D.W. Prevalence of antibiotic resistance in anaerobic bacteria: worrisome developments. Clin Infect Dis 2004, 39:92-97.
15. Hospenthal D.R., Murray C.K., Andersen R.C., Bell R.B., Calhoun J.H., Cancio L.C., et al. Guidelines for the prevention of infections associated with combat-related injuries: 2011 update: endorsed by the Infectious Diseases Society of America and the Surgical Infection Society. J Trauma 2011, 71:S210-S234. 10.1097/TA.0b013e318227ac4b.
16. Ibnoulkhatib A., Lacroix J., Moine A., Archambaud M., Bonnet E., Laffosse J.M., et al. Post-traumatic bone and/or joint limb infections due to Clostridium spp. Orthop Traumatol Surg Res 2012, 98:696-705. 10.1016/j.otsr.2012.03.019.
17. Kalapila A., Pergam S., Pottinger P., Butler-Wu S., Whimbey E. Multidrug-resistant Bacteroides fragilis--Seattle, Washington, 2013. MMWR 2013, 62:694-696.
18. Karlowsky J.A., Walkty A.J., Adam H.J., Baxter M.R., Hoban D.J., Zhanel G.G. Prevalence of antimicrobial resistance among clinical isolates of Bacteroides fragilis group in Canada in 2010-2011: CANWARD surveillance study. Antimicrob Agents Chemother 2012, 56:1247-1252. 10.1128/AAC.05823-11.
19. Katsandri A., Papaparaskevas J., Pantazatou A., Petrikkos G.L., Thomopoulos G., Houhoula D.P., et al. Two cases of infections due to multidrug-resistant Bacteroides fragilis group strains. J Clin Microbiol 2006, 44:3465-3467.
20. Kovaric J.J., Matsumoto T., Dobek A.S., Hamit H.F. Bacterial flora of one hundred and twelve combat wounds. Mil Med 1968, 133:622-624.
21. Lee Y., Park Y., Kim M.S., Yong D., Jeong S.H., Lee K., et al. Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea. Antimicrob Agents Chemother 2010, 54:3993-3997. 10.1128/AAC.00481-10.
22. Lindberg R.B., Wetzler T.F., Marshall J.D., Newton A., Strawitz J.G., Howard J.M. The bacterial flora of battle wounds at the time of primary debridement - a study of the Korean battle casualty. Ann Surg 1955, 141:369-374.
23. MacLennan J.D. Anaerobic infection of war wounds in the Middle East. Lancet 1943, 2:63-66.
24. Miles A.A., Schwabacher H., Cunliffe A.C., Ross J.P., Spooner E.T., Pilcher R.S., et al. Hospital infection of war wounds. Br Med J 1940, 2:895-900.
25. Murray C.K. Epidemiology of infections associated with combat-related injuries in Iraq and Afghanistan. J Trauma 2008, 64:S232-S238. 10.1097/TA.0b013e318163c3f5.
26. Murray C.K., Hinkle M.K., Yun H.C. History of infections associated with combat-related injuries. J Trauma 2008, 64:S221-S231. 10.1097/TA.0b013e318163c40b.
27. Murray C.K., Wilkins K., Molter N.C., Yun H.C., Dubick M.A., Spott M.A., et al. Infections in combat casualties during Operations Iraqi and Enduring Freedom. J Trauma 2009, 66:S138-S144. 10.1097/TA.0b013e31819d894c.
28. Murray C.K., Yun H.C., Griffith M.E., Thompson B., Crouch H.K., Monson L.S., et al. Recovery of multidrug-resistant bacteria from combat personnel evacuated from Iraq and Afghanistan at a single military treatment facility. Mil Med 2009, 174:598-604.
29. Murray C.K., Obremskey W.T., Hsu J.R., Andersen R.C., Calhoun J.H., Clasper J.C., et al. Prevention of infections associated with combat-related extremity injuries. J Trauma 2011, 71:S235-S257. 10.1097/TA.0b013e318227ac5f.
30. Nagy E., Urban E., Nord C.E. ESCMID Study Group on Antimicrobial Resistance in Anaerobic Bacteria. Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe: 20 years of experience. Clin Microbiol Infect 2011, 17:371-379. 10.1111/j.1469-0691.2010.03256.x.
31. Nguyen M.H., Yu V.L., Morris A.J., McDermott L., Wagener M.W., Harrell L., et al. Antimicrobial resistance and clinical outcome of Bacteroides bacteremia: findings of a multicenter prospective observational trial. Clin Infect Dis 2000, 30:870-876.
32. Park Y., Choi J.Y., Yong D., Lee K., Kim J.M. Clinical features and prognostic factors of anaerobic infections: a 7-year retrospective study. Korean J Intern Med 2009, 24:13-18. 10.3904/kjim.2009.24.1.13.
33. Redondo M.C., Arbo M.D., Grindlinger J., Snydman D.R. Attributable mortality of bacteremia associated with the Bacteroides fragilis group. Clin Infect Dis 1995, 20:1492-1496.
34. Schuetz A.N. Antimicrobial resistance and susceptibility testing of anaerobic bacteria. Clin Infect Dis 2014, 59:698-705. 10.1093/cid/ciu395.
35. Sherwood J.E., Fraser S., Citron D.M., Wexler H., Blakely G., Jobling K., et al. Multi-drug resistant Bacteroides fragilis recovered from blood and severe leg wounds caused by an improvised explosive device (IED) in Afghanistan. Anaerobe 2011, 17:152-155. 10.1016/j.anaerobe.2011.02.007.
36. Snydman D.R., Jacobus N.V., McDermott L.A., Golan Y., Hecht D.W., Goldstein E.J., et al. Lessons learned from the anaerobe survey: historical perspective and review of the most recent data (2005-2007). Clin Infect Dis 2010, 50(Suppl. 1):S26-S33. 10.1086/647940.
37. Thomas F., Hehemann J.H., Rebuffet E., Czjek M., Michel G. Environmental and gut bacteroidetes: the food connection. Front Microbiol 2011, 2:93. 10.3389/fmicb.2011.00093.
38. Tong M.J. Septic complications of war wounds. JAMA 1972, 219:1044-1047.
39. Tribble D.R., Conger N.G., Fraser S., Gleeson T.D., Wilkins K., Antonille T., et al. Infection-associated clinical outcomes in hospitalized medical evacuees after traumatic injury: Trauma Infectious Disease Outcome Study. J Trauma 2011, 71:S33-S42. 10.1097/TA.0b013e318221162e.
40. Wannamaker G.T., Pulaski E.J. Pyogenic neurosurgical infections in Korean battle casualties. J Neurosurg 1958, 15:512-518.
41. Warkentien T., Rodriguez C., Lloyd B., Wells J., Weintrob A., Dunne J.R., et al. Invasive mold infections following combat-related injuries. Clin Infect Dis 2012, 55:1441-1449. 10.1093/cid/cis749.
42. Weintrob A.C., Weisbrod A.B., Dunne J.R., Rodriguez C.J., Malone D., Lloyd B.A., et al. Combat trauma-associated invasive fungal wound infections: Epidemiology and clinical classification. Epidemiol Infect 2015, 143:214-224. 10.1017/S095026881400051X.
43. Wybo I., Van den Bossche D., Soetens O., Vekens E., Vandoorslaer K., Claeys G., et al. Fourth Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria. J Antimicrob Chemother 2014, 69:155-161. 10.1093/jac/dkt344.