Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

ChemBioChem

Volumn 16, Issue 17, 2015, Pages 2507-2512

  Esposito, Francesca ^a   Tintori, Cristina ^b   Martini, Riccardo ^b   Christ, Frauke ^c   Debyser, Zeger ^c   Ferrarese, Roberto ^d   Cabiddu, Gianluigi ^a   Corona, Angela ^a   Ceresola, Elisa Rita ^d   Calcaterra, Andrea ^e   Iovine, Valentina ^e   Botta, Bruno ^e   Clementi, Massimo ^d   Canducci, Filippo ^d,f   Botta, Maurizio ^b   Tramontano, Enzo ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^d SAN RAFFAELE HOSPITAL   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f UNIVERSITY OF INSUBRIA   (Italy)

Author keywords

allosterism; HIV 1 integrase; inhibitors; integrase multimerization; kuwanon L; protein protein interactions

Indexed keywords

DOLUTEGRAVIR; INTEGRASE; INTEGRASE INHIBITOR; KUWANON L; LENS EPITHELIUM DERIVED GROWTH FACTOR; LIGAND; PROTEIN P75; SUCROSE; UNCLASSIFIED DRUG; FLAVONOID; FLAVONOLIGNAN; KUWANON-L; P31 INTEGRASE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; RECOMBINANT PROTEIN;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DRUG BINDING SITE; DRUG SCREENING; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; THEORETICAL MODEL; VIRUS CELL INTERACTION; VIRUS INHIBITION; BINDING SITE; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; MORUS; PHYSIOLOGY; PLANT ROOT; PROTEIN TERTIARY STRUCTURE; VIRUS REPLICATION;

ALLOSTERIC REGULATION; BINDING SITES; CELL LINE; FLAVONOIDS; FLAVONOLIGNANS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; MOLECULAR DOCKING SIMULATION; MORUS; PLANT ROOTS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; VIRUS REPLICATION;

EID: 84954369076     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201500385     Document Type: Article

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