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Volumn 6, Issue 2, 2011, Pages 258-261

Fragment-Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus1

(7) Wielens, Jerome a,b Headey, Stephen J a Deadman, John J c,d Rhodes, David I c,d Parker, Michael W b,e Chalmers, David K a Scanlon, Martin J a

a MONASH UNIVERSITY (Australia)

b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH (Australia)

c Avexa Ltd (Australia)

d Current address: JDJ Bioservices Pty Ltd (Australia)

e UNIVERSITY OF MELBOURNE (Australia)

Author keywords

Antiviral agents; Fragment based drug design; HIV 1 integrase; NMR spectroscopy

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; INTEGRASE; KM 00835; SB 00942; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG DESIGN; ENZYME ACTIVE SITE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING;

BINDING SITES; CATALYSIS; HIV INTEGRASE; HYDROGEN BONDING; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR;

EID: 79251549481 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201000483 Document Type: Article

Times cited : (28)

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