Hypoglycaemic effects of functional tri-peptides from silk in differentiated adipocytes and streptozotocin-induced diabetic mice

Journal of the Science of Food and Agriculture

Volumn 96, Issue 1, 2016, Pages 116-121

  Han, Bok Kyung ^a   Lee, Hyun Jung ^b   Lee, Hyun Sun ^c   Suh, Hyung Joo ^b   Park, Yooheon ^b  

^a BK Bio Co Ltd   (South Korea)

^b Korea University   (South Korea)

^c Food Quality and Safety Department   (South Korea)

Author keywords

3T3 L1 adipocyte; Alcalase; Glucose uptake; Silk peptide E5K6; STZ induced diabetic mice

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORTER 4; GLYCYL-TYROSYL-GLYCINE; OLIGOPEPTIDE; SILK; SLC2A4 PROTEIN, MOUSE;

3T3 CELL LINE; ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; INSTITUTE FOR CANCER RESEARCH MOUSE; LIPID METABOLISM; MALE; METABOLISM; MOUSE;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE INTOLERANCE; GLUCOSE TRANSPORTER TYPE 4; HYPOGLYCEMIC AGENTS; LIPID METABOLISM; MALE; MICE; MICE, INBRED ICR; OLIGOPEPTIDES; SILK;

EID: 84954368958     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.7067     Document Type: Article

References (29)

1. Davis SN and Granner DK, Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas, in Goodman & Gilman's, The Pharmacological Basis of Therapeutics, 10th edition. McGrow Hill, New York, pp. 1704-1705 (1996).
2. Yeh GY, Eisenberg DM, Kaptchuk TJ and Phillips RS, Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 26:1277-1294 (2003).
3. Pari L and Umamaheswari J, Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats. Phytother Res 14:136-138 (2000).
4. Tiwari AK and Rao JM, Diabetes mellitus and multiple therapeutic approaches of phytochemicals: Present status and future prospects. Curr Sci 83:30-38 (2002).
5. Kurosaki S, Otsuka H, Kunitomo M, Koyama M, Pawankar R and Matumoto K, Fibroin allergy: IgE mediated hypersensitivity to silk suture materials. Nippon Ika Daigaku Zasshi 66:41-44 (1999).
6. Santin M, Motta A, Freddi G and Cannas M, In vitro evaluation of the inflammatory potential of the silk fibroin. J Biomed Mater Res 46:382-389 (1999).
7. Gotoh K, Izumi H, Kanamoto T, Tamada Y and Nakashima H, Sulfated fibroin, a novel sulfated peptide derived from silk, inhibits human immunodeficiency virus replication in vitro. Biosci Biotechnol Biochem 64:1664-1670 (2000).
8. Shin S, Yeon S, Park D, Oh J, Kang H, Kim S, et al, Silk amino acids improve physical stamina and male reproductive function of mice. Biol Pharm Bull 33:273-278 (2010).
9. Singh TM, Kadowaki MH, Glagov S and Zarins CK, Role of fibrinopeptide B in early atherosclerotic lesion formation. Am J Surg 160:156-159 (1990).
10. Gao J, Bai J, Man Q and Liu G, Effects of silk hydrates on the blood glucose metabolism in rats with experimental diabetes. J Hygiene Res 29:223-225 (2000).
11. Hyun CK, Kim IY and Frost SC, Soluble fibroin enhances insulin sensitivity and glucose metabolism in 3 T3-L1 adipocytes. J Nutr 134:3257-3263 (2004).
12. Lee YS, Park MJ, Choi JE, Kim JY, Nam MS and Jeong YH, Effects of silk protein hydrolysates on blood glucose level, serum insulin and leptin secretion in OLETF rats. J Korean Soc Food Sci Nutr 36:703-707 (2007).
13. Jung EY, Lee HS, Lee HJ, Kim JM, Lee KW and Suh HJ, Feeding silk protein hydrolysates to C57BL/KsJ-db/db mice improves blood glucose and lipid profiles. Nutr Res 30:783-790 (2010).
14. Lee HS, Lee HJ and Suh HJ, Silk protein hydrolysate increases glucose uptake through up-regulation of GLUT 4 and reduces the expression of leptin in 3 T3-L1 fibroblast. Nutr Res 11:35-41 (2011).
15. Lee HJ, Lee HS, Choi JW, Ra KS, Kim JM and Suh HJ, Novel tripeptides with α-glucosidase inhibitory activity isolated from silk cocoon hydrolysate. J Agric Food Chem 59:11522-11525 (2011).
16. Zhou CZ, Confalonieri F, Jacquet M, Perasso R, Li CH and Janin J, Silk fibroin: Structural implications of a remarkable amino acid sequence. Proteins Struct Funct Genet 44:119-122 (2001).
17. Zhou CZ, Confalonieri F, Medina N, Zivanovic Y, Esnault C, Yang T, et al, Fine organization of Bombyx mori fibroin heavy chain gene. Nucleic Acid Res 28:2413-2419 (2000).
18. Herman MA and Kahn BB, Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest 116:1767 (2006).
19. Watson RT, Kanzaki M and Pessin JE, Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes. Endocrine Rev 25:177-204 (2004).
20. Weiland M, Schürmann A, Schmidt W and Joost H, Development of the hormone-sensitive glucose transport activity in differentiating 3 T3-L1 murine fibroblasts. Role of the two transporter species and their subcellular localization. Biochem J 270:331 (1990).
21. Khan A and Pessin J, Insulin regulation of glucose uptake: A complex interplay of intracellular signalling pathways. Diabetologia 45:1475-1483 (2002).
22. Liu F, Kim J, Li Y, Liu X, Li J and Chen X, An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activities in 3 T3-L1 cells. J Nutr 131:2242-2247 (2001).
23. Roffey B, Atwal AS, Johns T and Kubow S, Water extracts from Momordica charantia increase glucose uptake and adiponectin secretion in 3 T3-L1 adipose cells. J Ethnopharmacol 112:77 (2007).
24. Havel PJ, Role of Adipose Tissue in Body-weight Regulation: Mechanisms Regulating Leptin Production and Energy Balance. Cambridge University Press, Cambridge, pp. 359-371 (2000).
25. Takamura T, Ando H, Nagai Y, Yamashita H, Nohara E and Kobayashi K, Pioglitazone prevents mice from multiple low-dose streptozotocin-induced insulitis and diabetes. Diabetes Res Clin Pract 44:107-114 (1999).
26. Han GC, Ko SK, Sung JH and Chung SH, Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. J Agric Food Chem 55:10641-10648 (2007).
27. Ko BS, Choi SB, Park SK, Jang JS, Kim YE and Park S, Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma. Biol Pharm Bull 28:1431-1437 (2005).
28. Liao W, Nguyen MTA, Imamura T, Singer O, Verma IM and Olefsky JM, Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3 T3-L1 adipocytes. Endocrinology 147:2245-2252 (2006).
29. Kim ED, Kim E, Lee JH and Hyun CK, Gly-Ala-Gly-Val-Gly-Tyr, a novel synthetic peptide, improves glucose transport and exerts beneficial lipid metabolic effects in 3 T3-L1 adipoctyes. Eur J Pharmacol 650:479-485 (2011).