Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Hypertensive Patients with Primary Hyperaldosteronemia: Role of 5,6,7,8-Tetrahydrobiopterin Oxidation and Endothelial Nitric Oxide Synthase Uncoupling

Hypertension

Volumn 67, Issue 2, 2016, Pages 430-439

  Chen, Long ^a   Ding, Mei Lin ^a   Wu, Fang ^a   He, Wen ^a   Li, Jin ^a   Zhang, Xiao Yu ^a   Xie, Wen Li ^a   Duan, Sheng Zhong ^b   Xia, Wen Hao ^a   Tao, Jun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Inst of Navy Med of Chinese PLA   (China)

Author keywords

Blood pressure; hypertension; nitric oxide synthase type III; oxidative stress; sapropterin

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; MINERALOCORTICOID RECEPTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE P47 PHOX; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SPIRONOLACTONE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG; BIOPTERIN; NITRIC OXIDE SYNTHASE; SAPROPTERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY DILATATION; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; BRACHIAL ARTERY; CAROTID ARTERY INJURY; CELL FUNCTION; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DEGRADATION; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL PROGENITOR CELL; ESSENTIAL HYPERTENSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; COMPLICATION; DISEASE MODEL; FOLLOW UP; HYPERCHOLESTEROLEMIA; HYPERTENSION; METABOLISM; NUDE MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETROSPECTIVE STUDY; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; BIOPTERIN; BLOOD PRESSURE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIAL PROGENITOR CELLS; ENDOTHELIUM, VASCULAR; FOLLOW-UP STUDIES; HUMANS; HYPERCHOLESTEROLEMIA; HYPERTENSION; MICE; MICE, NUDE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; RETROSPECTIVE STUDIES; VASODILATION;

EID: 84954365173     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.06597     Document Type: Article

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