CXCR4 gene transfer contributes to in vivo reendothelialization capacity of endothelial progenitor cells

Cardiovascular Research

Volumn 88, Issue 3, 2010, Pages 462-470

  Chen, Long ^a   Wu, Fang ^a   Xia, Wen Hao ^a   Zhang, Yuan Yuan ^a   Xu, Shi Yue ^a   Cheng, Fei ^a   Liu, Xin ^a   Zhang, Xiao Yu ^a   Wang, Shen Ming ^a   Tao, Jun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

CXCR4; Endothelial progenitor cells; Endothelium; Gene therapy; Reendothelialization

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; ENHANCED GREEN FLUORESCENT PROTEIN; FIBRONECTIN; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE;

ADENOVIRUS 5; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAROTID ARTERY INJURY; CELL ADHESION; CELL CYCLE ARREST; CELL LABELING; CELL MIGRATION; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; FLOW CYTOMETRY; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEM CELL; STEM CELL EXPANSION; STEM CELL TRANSPLANTATION; WESTERN BLOTTING;

ADENOVIRIDAE; ADULT; ANIMALS; CAROTID ARTERIES; CAROTID ARTERY INJURIES; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; JANUS KINASE 2; MALE; MESENCHYMAL STEM CELLS; MICE; MICE, NUDE; MODELS, ANIMAL; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION;

EID: 78149320571     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvq207     Document Type: Article

References (35)

1. Ross R. Atherosclerosis\-an inflammatory disease. N Engl J Med 1999;340:115-126.
2. Landmesser U, Hornig B, Drexler H. Endothelial function: a critical determinant in atherosclerosis? Circulation 2004;109(Suppl. 1):II27-II33.
3. Tao J, Jin YF, Yang Z, Wang LC, Gao XR, Lui L et al. Reduced arterial elasticity is associated with endothelial dysfunction in persons of advancing age: comparative study of noninvasive pulse wave analysis and laser Doppler blood flow measurement. Am J Hypertens 2004;17:654-659.
4. Wang JM, Huang YJ, Wang Y, Xu MG, Wang LC, Wang SM et al. Increased circulating CD31+/CD422 microparticles are associated with impaired systemic artery elasticity in healthy subjects. Am J Hypertens 2007;20:957-964.
5. Bauters C, Isner JM. The biology of restenosis. Prog Cardiovasc Dis 1997;40:107-116.
6. Kinlay S, Libby P, Ganz P. Endothelial function and coronary artery disease. Curr Opin Lipidol 2001;12:383-389.
7. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-967.
8. Dzau VJ, Gnecchi M, Pachori AS, Morello F, Melo LG. Therapeutic potential of endo-thelial progenitor cells in cardiovascular disease. Hypertension 2005;46:7-18.
9. Lamping K. Endothelial progenitor cells sowing the seeds for vascular repair. Circ Res 2007;100:1243-1245.
10. Gulati R, Jevremovic D, Peterson TE, Witt TA, Kleppe LS, Mueske CS et al. Autolo-gous culture-modified mononuclear cells confer vascular protection after arterial injury. Circulation 2003;108:1520-1526.
11. Griese DP, Ehsan A, Melo LG, Kong D, Zhang L, Mann MJ et al. Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. Circulation 2003;108: 2710-2715.
12. Yang Z, Tao J, Wang JM, Tu C, Xu MG, Wang Y et al. Shear stress contributes to t-PA mRNA expression in human endothelial progenitor cells and nonthrombogenic potential of small diameter artificial vessels. Biochem Biophys Res Commun 2006;342: 577-584.
13. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003;348:593-600.
14. Werner N, Nickenig G. Influence of cardiovascular risk factors on endothelial progenitor cells: limitations for therapy? Arterioscler Thromb Vasc Biol 2006;26:257-266.
15. Tao J, Wang Y, Yang Z, Tu C, Xu MG, Wang JM. Circulating endothelial progenitor cell deficiency contributes to impaired arterial elasticity in persons of advancing age. J Hum Hypertens 2006;20:490-495.
16. Sainz J, Sata M. CXCR4, a key modulator of vascular progenitor cells. Arterioscler Thromb Vasc Biol 2007;27:263-265.
17. Hristov M, Zernecke A, Bidzhekov K, Liehn EA, Shagdarsuren E, Ludwig A et al. Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury. Circ Res 2007;100: 590-597.
18. Tao J, Yang Z, Wang J, Tu C, Pan SR. Effects of fluid shear stress on eNOS mRNA expression and NO production in human endothelial progenitor cells. Cardiology 2006;106:82-88.
19. Yang Z, Wang JM, Wang LC, Chen L, Tu C, Luo CF et al. In vitro shear stress modulates antithrombogenic potentials of human endothelial progenitor cells. J Thromb Thrombolysis 2007;23:121-127. (Pubitemid 46416857)
20. Tao J, Yang Z, Wang JM, Wang LC, Luo CF, Tang AL et al. Shear stress increases Cu/ Zn SOD activity and mRNA expression in human endothelial progenitor cells. J Hum Hypertens 2007;21:353-358. (Pubitemid 46637941)
21. Xu MG, Wang JM, Chen L, Wang Y, Yang Z, Tao J. Berberine-induced upregulation of circulating endothelial progenitor cells is related to nitric oxide production in healthy subjects. Cardiology 2009;112:279-286.
22. Zampetaki A, Kirton JP, Xu QB. Vascular repair by endothelial progenitor cells. Car-diovasc Res 2008;78:413-421.
23. Leone AM, Valgimigli M, Giannico MB, Zaccone V, Perfetti M, D'Amario D et al. From bone marrow to the arterial wall: the ongoing tale of endothelial progenitor cells. Eur Heart J 2009;30:890-899.
24. Sorrentino SA, Bahlmann FH, Besler C, Muller M, Schulz S, Kirchhoff N et al. Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-g agonist rosiglitazone. Circulation 2007;116:163-173.
25. Giannotti G, Doerries C, Mocharla PS, Mueller MF, Bahlmann FH, Horvàth T et al. Impaired endothelial repair capacity of early endothelial progenitor cells in prehyper-tension: relation to endothelial dysfunction. Hypertension 2010;55:1389-1397.
26. Sanada F, Taniyama Y, Azuma J, Iekushi K, Dosaka N, Yokoi T et al. Hepatocyte growth factor, but not vascular endothelial growth factor, attenuates angiotensin II-induced endothelial progenitor cell senescence. Hypertension 2009;53:77-82.
27. Werner N, Junk S, Laufs U, Link A, Walenta K, Bohm M et al. Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury. Circ Res 2003;93:e17-e24.
28. Walter DH, Haendeler J, Reinhold J, Rochwalsky U, Seeger F, Honold J et al. Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endo-thelial progenitor cells from patients with coronary artery disease. Circ Res 2005; 97:1142-1151.
29. Dimmeler S, Zeiher AM. Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis? J Mol Med 2004;82:671-677.
30. Urbich C, Aicher A, Heeschen C, Dernbach E, Hofmann WK, Zeiher AM et al. Soluble factors released by endothelial progenitor cells promote migration of endo-thelial cells and cardiac resident progenitor cells. J Mol Cell Cardiol 2005;39:733-742.
31. Urbich C, Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res 2004;95:343-353.
32. Hristov M, Zernecke A, Liehn EA, Weber C. Regulation of endothelial progenitor cell homing after arterial injury. Thromb Haemost 2007;98:274-277.
33. Hur J, Yoon CH, Lee CS, Kim TY, Oh IY, Park KW et al. Akt is a key modulator of endothelial progenitor cell trafficking in ischemic muscle. Stem Cells 2007;25: 1769-1778.
34. Walter DH, Rochwalsky U, Reinhold J, Seeger F, Aicher A, Urbich C et al. Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor. Arterioscler Thromb Vasc Biol 2007;27:275-282.
35. Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A et al. Circulating endo-thelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005;353: 999-1007. (Pubitemid 41262334)