DOT1L Activity Promotes Proliferation and Protects Cortical Neural Stem Cells from Activation of ATF4-DDIT3-Mediated ER Stress in Vitro

Stem Cells

Volumn 34, Issue 1, 2016, Pages 233-245

  Roidl, Deborah ^a   Hellbach, Nicole ^a   Bovio, Patrick P ^a   Villarreal, Alejandro ^a   Heidrich, Stefanie ^a   Nestel, Sigrun ^a   Grüning, Björn A ^a   Boenisch, Ulrike ^b   Vogel, Tanja ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

Cerebral cortex; Endoplasmic reticulum stress; H3K79; Histone H3 methylation; Neural stem cells; Unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LYSINE METHYLTRANSFERASE DOT1L; METHYLTRANSFERASE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; ATF4 PROTEIN, MOUSE; BENZIMIDAZOLE DERIVATIVE; DDIT3 PROTEIN, MOUSE; DOT1L PROTEIN, MOUSE; EPZ-5676; HISTONE; LYSINE;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HISTONE METHYLATION; IN VITRO STUDY; MOUSE; NEURAL STEM CELL; NONHUMAN; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; UNFOLDED PROTEIN RESPONSE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; METHYLATION; NEUROPROTECTION; ULTRASTRUCTURE;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; BENZIMIDAZOLES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION; HISTONES; LYSINE; METHYLATION; METHYLTRANSFERASES; MICE; NEURAL STEM CELLS; NEUROPROTECTION; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION, GENETIC;

EID: 84954363608     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2187     Document Type: Article

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