Exacerbated and prolonged inflammation impairs wound healing and increases scarring

Wound Repair and Regeneration

Volumn 24, Issue 1, 2016, Pages 26-34

  Qian, Li Wu ^a   Fourcaudot, Andrea B ^a   Yamane, Kazuyoshi ^a   You, Tao ^a   Chan, Rodney K ^a   Leung, Kai P ^a  

^a US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MYELOPEROXIDASE; PATHOGEN ASSOCIATED MOLECULAR PATTERN; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; MESSENGER RNA; PEROXIDASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GRANULE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE EXACERBATION; EOSINOPHIL; EPITHELIZATION; FEMALE; GENE EXPRESSION; HISTOLOGY; HYPERTROPHIC SCAR; IMMUNOHISTOCHEMISTRY; INFLAMMATION; NEUTROPHIL; NONHUMAN; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCAR FORMATION; WOUND CLOSURE; WOUND HEALING; ANIMAL; CYTOLOGY; DISEASE COURSE; DISEASE MODEL; EXTERNAL EAR; GENETICS; IMMUNOLOGY; INJURIES; METABOLISM; PATHOLOGY; RABBITS AND HARES; TIME FACTOR;

ANIMALS; CICATRIX, HYPERTROPHIC; CYTOKINES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EAR, EXTERNAL; FEMALE; INFLAMMATION; INTERLEUKIN-6; NEUTROPHILS; PEROXIDASE; PSEUDOMONAS AERUGINOSA; RABBITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; WOUND HEALING;

EID: 84954271380     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/wrr.12381     Document Type: Article

References (33)

1. Gurtner GC, Werner S, Barrandon Y, Longaker MT,. Wound repair and regeneration. Nature 2008; 453: 314-21.
2. Satish L, Kathju S., Cellular and molecular characteristics of scarless versus fibrotic wound healing. Dermatol Res Pract 2010; 2010: 790234.
3. Singer AJ, Clark RA., Cutaneous wound healing. N Engl J Med 1999; 341: 738-46.
4. Werner S, Grose R., Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003; 83: 835-70.
5. Dovi JV, He LK, DiPietro LA., Accelerated wound closure in neutrophil-depleted mice. J Leukoc Biol 2003; 73: 448-55.
6. Pierce GF., Inflammation in nonhealing diabetic wounds: the space-time continuum does matter. Am J Pathol 2001; 159: 399-403.
7. Reish RG, Eriksson E., Scar treatments: preclinical and clinical studies. J Am Coll Surg 2008; 206: 719-30.
8. Coolen NA, Schouten KC, Boekema BK, Middelkoop E, Ulrich MM,. Wound healing in a fetal, adult, and scar tissue model: a comparative study. Wound Repair Regen 2010; 18: 291-301.
9. Leblebic B, Adam M, Bagis S, Tarim AM, Noyan T, Akman MN, et al., Quality of life after burn injury: the impact of joint contracture. J Burn Care Res 2006; 27: 864-8.
10. Nodder S, Martin P., Wound healing in embryos: a review. Anat Embryol (Berl) 1997; 195: 215-28.
11. Gronert K., Lipoxins in the eye and their role in wound healing. Prostaglandins Leukot Essent Fatty Acids 2005; 73: 221-9.
12. Gronert K., Lipid autacoids in inflammation and injury responses: a matter of privilege. Mol Interv 2008; 8: 28-35.
13. Streilein JW., Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation. J Leukoc Biol 2003; 74: 179-85.
14. Szpaderska AM, Zuckerman JD, DiPietro LA., Differential injury responses in oral mucosal and cutaneous wounds. J Dent Res 2003; 82: 621-6.
15. Murphy MA, Joyce WP, Condron C, Bouchier-Hayes D,. A reduction in serum cytokine levels parallels healing of venous ulcers in patients undergoing compression therapy. Eur J Vasc Endovasc Surg 2002; 23: 349-52.
16. Tang Y, Zhang MJ, Hellmann J, Kosuri M, Bhatnagar A, Spite M,. Proresolution therapy for the treatment of delayed healing of diabetic wounds. Diabetes 2013; 62: 618-27.
17. Hwang PF, Porterfield N, Pannell D, Davis TA, Elster EA,. Trauma is danger. J Transl Med 2011; 9: 92.
18. Stojadinovic A, Carlson JW, Schultz GS, Davis TA, Elster EA,. Topical advances in wound care. Gynecol Oncol 2008; 111 (Suppl.2): S70-80.
19. Marcker K, Sanger F., N-Formyl-Methionyl-S-Rna. J Mol Biol 1964; 8: 835-40.
20. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, et al., Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010; 464: 104-7.
21. Kataoka H, Kono H, Patel Z, Rock KL,. Evaluation of the contribution of multiple DAMPs and DAMP receptors in cell death-induced sterile inflammatory responses. PLoS One 2014; 9: e104741.
22. Nadkarni MA, Martin FE, Jacques NA, Hunter N,. Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set. Microbiology 2002; 148 (Pt 1): 257-66.
23. Galiano RD, Zhao LL, Clemmons DR, Roth SI, Lin X, Mustoe TA,. Interaction between the insulin-like growth factor family and the integrin receptor family in tissue repair processes. Evidence in a rabbit ear dermal ulcer model. J Clin Invest 1996; 98: 2462-8.
24. Kloeters O, Tandara A, Mustoe TA., Hypertrophic scar model in the rabbit ear: a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction. Wound Repair Regen 2007; 15 (Suppl 1): S40-5.
25. Said HK, Hijjawi J, Roy N, Mogford J, Mustoe T,. Transdermal sustained-delivery oxygen improves epithelial healing in a rabbit ear wound model. Arch Surg 2005; 140: 998-1004.
26. Gawande A., Casualties of war-military care for the wounded from Iraq and Afghanistan. N Engl J Med 2004; 351: 2471-5.
27. Escamilla-Tilch M, Filio-Rodriguez G, Garcia-Rocha R, Mancilla-Herrera I, Mitchison NA, Ruiz-Pacheco JA, et al., The interplay between pathogen-associated and danger-associated molecular patterns: an inflammatory code in cancer? Immunol Cell Biol 2013; 91: 601-10.
28. Kolaczkowska E, Kubes P., Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol 2013; 13: 159-75.
29. Murray PJ, Smale ST., Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways. Nat Immunol 2012; 13: 916-24.
30. Wilgus TA, Roy S, McDaniel JC., Neutrophils and wound repair: positive actions and negative reactions. Adv Wound Care (New Rochelle) 2013; 2: 379-388.
31. Jia S, Xie P, Hong SJ, Galiano R, Singer A, Clark RA, et al., Intravenous curcumin efficacy on healing and scar formation in rabbit ear wounds under nonischemic, ischemic, and ischemia-reperfusion conditions. Wound Repair Regen 2014; 22: 730-9.
32. O'Shaughnessy KD, De La Garza M, Roy NK, Mustoe TA,. Homeostasis of the epidermal barrier layer: a theory of how occlusion reduces hypertrophic scarring. Wound Repair Regen 2009; 17: 700-8.
33. Gurjala AN, Geringer MR, Seth AK, Hong SJ, Smeltzer MS, Galiano RD, et al., Development of a novel, highly quantitative in vivo model for the study of biofilm-impaired cutaneous wound healing. Wound Repair Regen 2011; 19: 400-10.