Determination of safety margins for whole blood concentrations of alcohol and nineteen drugs in driving under the influence cases

Forensic Science International

Volumn 259, Issue , 2016, Pages 119-126

  Kristoffersen, Lena ^a   Strand, Dag Helge ^a   Liane, Veronica Horpestad ^a   Vindenes, Vigdis ^a,c   Tvete, Ingunn Fride ^b   Aldrin, Magne ^b  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b NORWEGIAN COMPUTING CENTER   (Norway)

^c Faculty of Medicine   (Norway)

Author keywords

Blood alcohol concentration; Driving under influence (DUI); Drug; Legislative limits; Safety margins

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 4 HYDROXYBUTYRIC ACID; ALCOHOL; ALPRAZOLAM; AMPHETAMINE; BUPRENORPHINE; CLONAZEPAM; COCAINE; DIAZEPAM; FLUNITRAZEPAM; KETAMINE; METHADONE; METHAMPHETAMINE; MORPHINE; NITRAZEPAM; OXAZEPAM; PHENAZEPAM; PSYCHOTROPIC AGENT; TETRAHYDROCANNABINOL; ZOLPIDEM; ZOPICLONE; ALCOHOL BLOOD LEVEL; STREET DRUG;

ALCOHOL BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUNKEN DRIVING; GAS CHROMATOGRAPHY; HUMAN; LAW; MODEL; NORWAY; PRIORITY JOURNAL; REFERENCE VALUE; TANDEM MASS SPECTROMETRY; TRAFFIC SAFETY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; BAYES THEOREM; BLOOD; DRUG MISUSE; FORENSIC TOXICOLOGY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROCEDURES; STANDARDS; STATISTICS AND NUMERICAL DATA; SUBSTANCE ABUSE;

BAYES THEOREM; BLOOD ALCOHOL CONTENT; CHROMATOGRAPHY, LIQUID; DRIVING UNDER THE INFLUENCE; ETHANOL; FORENSIC TOXICOLOGY; HUMANS; MASS SPECTROMETRY; NORWAY; PRESCRIPTION DRUG MISUSE; STREET DRUGS; SUBSTANCE ABUSE DETECTION;

EID: 84954236959     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2015.12.009     Document Type: Article

References (19)

1. Norwegian Institute of Public Health, Funn i blodprøver hos bilførere mistenkt for påvirket kjøring 2012, in, 2013.
2. Vindenes V., Jordbru D., Knapskog A.B., Kvan E., Mathisrud G., Slordal L., Morland J. Impairment based legislative limits for driving under the influence of non-alcohol drugs in Norway. Forensic Sci. Int. 2012, 219:1-11.
3. Maurer H.H. What is the future of (ultra) high performance liquid chromatography coupled to low and high resolution mass spectrometry for toxicological drug screening?. J. Chromatogr. A 2013, 1292:19-24.
4. Peters F.T., Drummer O.H., Musshoff F. Validation of new methods. Forensic Sci. Int. 2007, 165:216-224.
5. European Medicines Agency, Guideline on bioanalytical method validation, in, 2011.
6. U.S. Department of Health and Human Services, Food and Drug Administration, Guidance for Industry Bioanalytical Method Validation, in, FDA, 2001.
7. Eurachem Citac Quantifying Uncertainity in Analytical Measurement 2012, S.L.R. Ellison, A. Williams (Eds.).
8. Kristoffersen L., Smith-Kielland A. An automated alcohol dehydrogenase method for ethanol quantification in urine and whole blood. J. Anal. Toxicol. 2005, 29:387-389.
9. Kristoffersen L., Stormyhr L.E., Smith-Kielland A. Headspace gas chromatographic determination of ethanol: the use of factorial design to study effects of blood storage and headspace conditions on ethanol stability and acetaldehyde formation in whole blood and plasma. Forensic Sci. Int. 2006, 161:151-157.
10. Oiestad E.L., Johansen U., Oiestad A.M., Christophersen A.S. Drug screening of whole blood by ultra-performance liquid chromatography-tandem mass spectrometry. J. Anal. Toxicol. 2011, 35:280-293.
11. Dahl S.R., Olsen K.M., Strand D.H. Determination of gamma-hydroxybutyrate (GHB), beta-hydroxybutyrate (BHB), pregabalin, 1,4-butane-diol (1,4BD) and gamma-butyrolactone (GBL) in whole blood and urine samples by UPLC-MSMS. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2012, 885-886:37-42.
12. Sauve E.N., Langodegard M., Ekeberg D., Oiestad A.M.L. Determination of benzodiazepines in ante-mortem and post-mortem whole blood by solid-supported liquid-liquid extraction and UPLC-MS/MS. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2012, 883-884:177-188.
13. Christophersen A.S. Tetrahydrocannabinol stability in whole blood: plastic versus glass containers. J. Anal. Toxicol. 1986, 10:129-131.
14. Gjerde H., Oiestad E.L., Oiestad A.M.L., Langodegard M., Gustavsen I., Hjelmeland K., Bernard J.P., Christophersen A.S. Comparison of zopiclone concentrations in oral fluid sampled with intercept oral specimen collection device and statsure saliva sampler and concentrations in blood. J. Anal. Toxicol. 2010, 34:590-593.
15. Gjerde H., Hasvold I., Pettersen G., Christophersen A.S. Determination of amphetamine and methamphetamine in blood by derivatization with perfluorooctanoyl chloride and gas chromatography/mass spectrometry. J. Anal. Toxicol. 1993, 17:65-68.
16. Berg T., Lundanes E., Christophersen A.S., Strand D.H. Determination of opiates and cocaine in urine by high pH mobile phase reversed phase UPLC-MS/MS. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2009, 877:421-432.
17. Berg T., Jorgenrud B., Strand D.H. Determination of buprenorphine, fentanyl and LSD in whole blood by UPLC-MS-MS. J. Anal. Toxicol. 2013, 37:159-165.
18. Gelman A., Carlin J.B., Stern H.S., Dunson D.B., Vehtari A., Rubin D.B. Bayesian Data Analysis 2013, CRC Press LLC. 3rd ed.
19. WinBUGS, in: MRC Medical Research Council (Ed.) MRC Biostatistic Unit.