Dextrose-mediated aggregation of therapeutic monoclonal antibodies in human plasma: Implication of isoelectric precipitation of complement proteins

mAbs

Volumn 7, Issue 6, 2015, Pages 1094-1103

  Luo, Shen ^a   Zhang, Baolin ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Aggregation; Compatibility; Complement proteins; Diluent; Isoelectric point; Monoclonal antibodies; Plasma; Product formulation; Therapeutic proteins

Indexed keywords

BEVACIZUMAB; DORNASE ALFA; GLUCOSE; INFLIXIMAB; MONOCLONAL ANTIBODY; TRASTUZUMAB; APOLIPOPROTEIN; COMPLEMENT; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; COMPLEMENT FACTOR H; FIBRONECTIN; PLASMA PROTEIN; PROTEIN BINDING;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; HUMAN; ISOELECTRIC POINT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; PLASMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN AGGREGATION; TANDEM MASS SPECTROMETRY; BLOOD; CHEMISTRY; METABOLISM; PROTEINOSIS;

ANTIBODIES, MONOCLONAL; APOLIPOPROTEINS; BEVACIZUMAB; BLOOD PROTEINS; CHROMATOGRAPHY, LIQUID; COMPLEMENT C3; COMPLEMENT C4; COMPLEMENT FACTOR H; COMPLEMENT SYSTEM PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FIBRONECTINS; GLUCOSE; HUMANS; HYDROGEN-ION CONCENTRATION; INFLIXIMAB; ISOELECTRIC POINT; MASS SPECTROMETRY; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN BINDING; TRASTUZUMAB;

EID: 84954229625     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.1080/19420862.2015.1087636     Document Type: Article

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