Analysis of particulate contaminations of infusion solutions in a pediatric intensive care unit

Intensive Care Medicine

Volumn 36, Issue 4, 2010, Pages 707-711

  Jack, Thomas ^a   Brent, Bernadette E ^a   Boehne, Martin ^a   Müller, Meike ^b   Sewald, Katherina ^b   Braun, Armin ^b   Wessel, Armin ^a   Sasse, Michael ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Contamination; Immune system; In line filtration; Infusion therapy; Particle

Indexed keywords

GLASS; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; SILICON; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL LEVEL; CHEMICAL COMPOSITION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; CYTOKINE RELEASE; CYTOTOXICITY; DRUG CONTAMINATION; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; INFLAMMATION; INFUSION; INTENSIVE CARE UNIT; MACROPHAGE; MEMBRANE FILTER; MOUSE; NONHUMAN; OBSERVATIONAL STUDY; PARTICULATE MATTER; PHYSICAL CHEMISTRY; PROSPECTIVE STUDY; SPECTROSCOPY;

ANIMALS; CELL CULTURE TECHNIQUES; CRITICAL ILLNESS; CYTOKINES; DRUG CONTAMINATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FILTRATION; HUMANS; INFUSIONS, INTRAVENOUS; INTENSIVE CARE UNITS, PEDIATRIC; MACROPHAGES; MICE; MICROSCOPY, ELECTRON; PARTICLE SIZE; PHARMACEUTICAL SOLUTIONS; PROSPECTIVE STUDIES; SPECTROMETRY, X-RAY EMISSION; UMBILICAL VEINS;

EID: 77951207303     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-010-1775-y     Document Type: Article

References (20)

1. HH Mehrkens E Klaus JE Schmitz 1977 Possibilities of material contamination due to additional injections Klin Anasthesiol Intensivther 14 106 113 926676
2. H Walpot RP Franke WG Burchard C Agternkamp FG Müller C Mittermayer G Kalff 1989 Particulate contamination of infusion solutions and drug additives within the scope of long-term intensive therapy. 1: Energy dispersion electron images in the scanning electron microscope-REM/EDX Anaesthesist 38 544 548 1:STN:280:DyaK3c%2Fnt1Kgtg%3D%3D 2511778
3. H Walpot RP Franke WG Burchard C Agternkamp FG Müller C Mittermayer G Kalff 1989 Particulate contamination of infusion solutions and drug additives in the framework of long-term intensive therapy. 2: An animal model Anaesthesist 38 617 621 1:CAS:528:DyaK3cXkvVOntg%3D%3D 2635837
4. JW Puntis KM Wilkins PA Ball DI Rushton IW Booth 1992 Hazards of parenteral treatment: do particles count? Arch Dis Child 67 1475 1477 10.1136/adc.67.12.1475 1:STN:280:DyaK3s7ktlertA%3D%3D 1489228
5. HA Lehr J Brunner R Rangoonwala CJ Kirkpatrick 2002 Particulate matter contamination of intravenous antibiotics aggravates loss of functional capillary density in postischemic striated muscle Am J Respir Crit Care Med 165 514 520 11850345
6. SC Schaefer PA Bison R Rangoonwala CJ Kirckpatrick HA Lehr 2008 0.2 μm in-line filters prevent capillary obstruction by particulate contaminants of generic antibiotic preparations in postischemic muscle Chemother J 17 172 178
7. KH Falchuk L Peterson BJ McNeil 1985 Microparticulate-induced phlebitis: its prevention by in-line filtration N Engl J Med 312 78 82 1:STN:280: DyaL2M%2FmtFCluw%3D%3D 3880597
8. RA van Lingen W Baerts AC Marquering GJ Ruijs 2004 The use of in-line intravenous filters in sick newborn infants Acta Paediatr 93 658 662 10.1080/08035250410026608 15174791 (Pubitemid 38570235)
9. Brent BE, Müller M, Jack T (2007) Harmful effects of infused particles. Abstract P 44.3.1004. 5th World Congress on Pediatric Critical Care, June 24-28, Geneva, Switzerland
10. CW Dunnett 1955 A multiple comparison procedure for comparing several treatments with a control J Am Stat Assoc 50 1096 1121 10.2307/2281208
11. Levick JR (2003) Introduction to cardiovascular physiology, 2nd edn. Oxford University Press, Oxford
12. S Oie A Kamiya 2005 Particulate and microbial contamination in in-use admixed parenteral nutrition solutions Biol Pharm Bull 28 2268 2270 10.1248/bpb.28.2268 1:CAS:528:DC%2BD28Xms1Gjuw%3D%3D 16327163
13. K Yorioka S Oie M Oomaki A Imamura A Kamiya 2006 Particulate and microbial contamination in in-use admixed intravenous infusions Biol Pharm Bull 29 2321 2323 10.1248/bpb.29.2321 1:CAS:528:DC%2BD2sXms1Cguw%3D%3D 17077539 (Pubitemid 44690967)
14. A Hellinger J Piotrowski MA Konerding WG Burchard N Doetsch K Peitgen J Erhard JC Reidemeister 1997 Impact of particulate contamination in crystalloid cardioplegic solutions: studies by scanning and transmission electron microscopy Thorac Cardiovasc Surg 45 20 26 10.1055/s-2007-1013678 1:STN:280: DyaK2s3ksFaisw%3D%3D 9089970
15. H Schulz V Harder A Ibald-Mulli A Khandoga W Koenig F Krombach R Radykewicz A Stampfl B Thorand A Peters 2005 Cardiovascular effects of fine and ultrafine particles J Aerosol Med 18 1 22 10.1089/jam.2005.18.1 1:CAS:528:DC%2BD2MXhslGntL8%3D 15741770 (Pubitemid 40349943)
16. CD Heidecke H Weighardt T Hensler H Bartels B Holzmann 2000 Immune paralysis of T-lymphocytes and monocytes in postoperative abdominal sepsis: correlation of immune function with survival Chirurg 71 159 165 10.1007/s001040050028 1:STN:280:DC%2BD3c7pvVOmuw%3D%3D 10734584
17. F Pinheiro da Silva V Nizet 2009 Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection Apoptosis 14 509 521 10.1007/s10495-009-0320-3 19199035
18. WJ Wiersinga C van't Veer PS van den Pangaart AM Dondorp NP Day SJ Peacock T van der Poll 2009 Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis) Crit Care Med 37 569 576 10.1097/CCM. 0b013e318194b1bf 1:CAS:528:DC%2BD1MXjs1Knu7c%3D 19114913
19. JP Kremer D Jarrar U Steckholzer W Ertel 1996 Interleukin-1,-6 and tumor necrosis factor-alpha release is down-regulated in whole blood from septic patients Acta Haematol 95 268 273 10.1159/000203895 1:CAS:528:DyaK28XktF2ktLw%3D 8677754
20. A van den Hoogen TG Krediet CS Uiterwaal JF Bolenius LJ Gerards A Fleer 2006 In-line filters in central venous catheters in a neonatal intensive care unit J Perinat Med 34 71 74 10.1515/JPM.2006.009 16489888 (Pubitemid 43106300)