Effects of antibiotic administration delay and inadequacy upon the survival of septic shock patients;Efectos del retraso y la inadecuación del tratamiento antibiótico en la supervivencia de los pacientes en shock séptico

Medicina Intensiva

Volumn 39, Issue 8, 2015, Pages 459-466

  Suberviola Canas B ^a   Jauregui R ^a   Ballesteros, M A ^a   Leizaola, O ^a   Gonzalez Castro A ^a   Castellanos Ortega, A ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

Author keywords

Antibiotics; Delay; Inadequacy; Mortality; Septic shock

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ARTICLE; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; MAJOR CLINICAL STUDY; MORTALITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; SEPTIC SHOCK; SURVIVAL PREDICTION; SURVIVAL RATE; THERAPY; THERAPY DELAY; TIME TO TREATMENT; TREATMENT INADEQUACY; ADULT; AGED; ANTIBIOTIC RESISTANCE; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; DRUG ADMINISTRATION; EPIDEMIOLOGY; FEMALE; HOSPITAL MORTALITY; KAPLAN MEIER METHOD; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC; SPAIN; STATISTICS AND NUMERICAL DATA; TERTIARY CARE CENTER; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE, MICROBIAL; FEMALE; HOSPITAL MORTALITY; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC; SPAIN; TERTIARY CARE CENTERS; TIME-TO-TREATMENT;

EID: 84954197079     PISSN: 02105691     EISSN: 15786749     Source Type: Journal    
DOI: 10.1016/j.medin.2014.12.006     Document Type: Article

References (34)

1. Kaukonen K.M., Bailey M., Suzuki S., Pilcher D., Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA. 2014, 311:1308-1316.
2. Noritomi D.T., Ranzani O.T., Monteiro M.B., Ferreira E.M., Santos S.R., Leibel F., et al. Implementation of a multifaceted sepsis education program in an emerging country setting: clinical outcomes and cost-effectiveness in a long-term follow-up study. Intensive Care Med. 2014, 40:182-191.
3. Castellanos-Ortega A., Suberviola B., García-Astudillo L.A., Holanda M.S., Ortiz F., Llorca J., et al. Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: Results of a three-year follow-up quasi-experimental study. Crit Care Med. 2010, 38:1036-1043.
4. Levy M.M., Dellinger R.P., Townsend S.R., Linde-Zwirble W.T., Marshall J.C., Bion J., et al. The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med 2010, 36:222-231.
5. Barochia A.V., Cui X., Vitberg D., Suffredini A.F., O'Grady N.P., Banks S.M., et al. Bundled care for septic shock: An analysis of clinical trials. Crit Care Med. 2010, 38:668-678.
6. Rivers E., Nguyen B., Havstad S., Ressler J., Muzzin A., Knoblich B., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001, 345:1368-1377. Early Goal-Directed Therapy Collaborative Group.
7. Yealy D.M., Kellum J.A., Huang D.T., Barnato A.E., Weissfeld L.A., Pike F., et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014, 370:1683-1693. ProCESS Investigators.
8. Kumar A., Roberts D., Wood K.E., Light B., Parrillo J.E., Sharma S., et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006, 34:1589-1596.
9. Garnacho-Montero J., Ortiz-Leyba C., Herrera-Melero I., Aldabó-Pallás T., Cayuela-Dominguez A., Marquez-Vacaro J.A., et al. Mortality and morbidity attributable to inadequate empirical antimicrobial therapy in patients admitted to the ICU with sepsis: A matched cohort study. J Antimicrob Chemother. 2008, 61:436-441.
10. Battleman D.S., Callahan M., Thaler H.T. Rapid antibiotic delivery and appropriate antibiotic selection reduce length of hospital stay of patients with community-acquired pneumonia: Link between quality of care and resource utilization. Arch Intern Med. 2002, 162:682-688.
11. Barlow G., Nathwani D., Davey P. The CURB65 pneumonia severity score outperforms generic sepsis and early warning scores in predicting mortality in community-acquired pneumonia. Thorax. 2007, 62:253-259.
12. Levy M.M., Fink M.P., Marshall J.C., Abraham E., Angus D., Cook D., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003, 31:1250-1256. SCCM/ESICM/ACCP/ATS/SIS.
13. Ferrer R., Martin-Loeches I., Phillips G., Osborn T.M., Townsend S., Dellinger R.P., et al. Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: Results from a guideline-based performance improvement program. Crit Care Med. 2014, 42:1749-1755.
14. Gaieski D.F., Mikkelsen M.E., Band R.A., Pines J.M., Massone R., Furia F.F., et al. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med. 2010, 38:1045-1053.
15. Ferrer R., Artigas A., Levy M.M., Blanco J., González-Díaz G., Garnacho-Montero J., et al. Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA. 2008, 299:2294-2330. Edusepsis Study Group.
16. Bloos F., Thomas-Rüddel D., Rüddel H., Engel C., Schwarzkopf D., Marshall J.C., et al. Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study. Crit Care. 2014, 18:R42. MEDUSA Study Group.
17. Puskarich M.A., Trzeciak S., Shapiro N.I., Arnold R.C., Horton J.M., Studnek J.R., et al. Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med. 2011, 39:2066-2071. Emergency Medicine Shock Research Network (EMSHOCKNET).
18. Leone M., Bourgoin A., Cambon S., Dubuc M., Albanèse J., Martin C. Empirical antimicrobial therapy of septic shock patients: Adequacy and impact on the outcome. Crit Care Med. 2003, 31:462-467.
19. Chen H.C., Lin W.L., Lin C.C., Hsieh W.H., Hsieh C.H., Wu M.H., et al. Outcome of inadequate empirical antibiotic therapy in emergency department patients with community-onset bloodstream infections. J Antimicrob Chemother. 2013, 68:947-953.
20. Valles J., León C., Alvárez-Lerma F. Nosocomial bacteremia in critically ill patients: A multicenter study evaluating epidemiology and prognosis. Clin Infect Dis 1997, 24:387-395.
21. Ibrahim E.H., Sherman G., Ward S., Fraser V.J., Kollef M.H. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest 2000, 118:146-155.
22. Fitousis K., Moore L.J., Hall J., Moore F.A., Pass S. Evaluation of empiric antibiotic use in surgical sepsis. Am J Surg. 2010, 200:776-782.
23. Zaragoza R., Artero A., Camarena J.J., Sancho S., González R., Nogueira J.M. The influence of inadequate empirical antimicrobial treatment on patients with bloodstream infections in an intensive care unit. Clin Microbiol Infect. 2003, 9:412-418.
24. Kang C.I., Kim S.H., Park W.B., Lee K.D., Kim H.B., Kim E.C., et al. Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: Risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicrob Agents Chemother 2005, 49:760-766.
25. Roghmann M.C. Predicting methicillin resistance and the effect of inadequate empiric therapy on survival in patients with Staphylococcus aureus bacteremia. Arch Intern Med 2000, 160:1001-1004.
26. Falagas M.E., Siempos I.I., Bliziotis I.A., Panos G.Z. Impact of initial discordant treatment with beta-lactam antibiotics on clinical outcomes in adults with pneumococcal pneumonia: A systematic review. Mayo Clin Proc 2006, 81:1567-1574.
27. Vallés J., Rello J., Ochagavía A., Garnacho J., Alacala M.A. Community-acquired bloodstream infection in critically ill adult patients: Impact of shock and inappropriate antibiotic therapy on survival. Chest. 2003, 123:1615-1624.
28. Garnacho-Montero J., Garcia-Garmendia J.L., Barrero-Almodovar A., Jimenez-Jimenez F.J., Perez-Paredes C., Ortiz-Leyba C. Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Crit Care Med. 2003, 31:2742-2751.
29. Kumar A., Ellis P., Arabi Y., Roberts D., Light B., Parrillo J.E., et al. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest. 2009, 136:1237-1248. Cooperative Antimicrobial Therapy of Septic Shock Database Research Group.
30. Dellinger R.P., Levy M.M., Rhodes A., Annane D., Gerlach H., Opal S.M., et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013, 41:580-637. Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup.
31. Sebat F., Musthafa A.A., Johnson D., Kramer A.A., Shoffner D., Eliason M., et al. Effect of a rapid response system for patients in shock on time to treatment and mortality during 5 years. Crit Care Med 2007, 35:2568-2575.
32. De Miguel-Yanes J.M., Andueza-Lillo J.A., González-Ramallo V.J., Pastor L., Muñoz J. Failure to implement evidence-based clinical guidelines for sepsis at the ED. Am J Emerg Med 2006, 24:553-559.
33. Van de Werf F., Ardissino D., Betriu A., Cokkinos D.V., Falk E., Fox K.A., et al. Managment of actute myocardial infarction in patients presenting with STsegment elevation. The Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 2003, 24:28-66.
34. Kuo Y.W., Chang H.T., Wu P.C., Chen Y.F., Lin C.K., Wen Y.F., et al. Compliance and barriers to implementing the sepsis resuscitation bundle for patients developing septic shock in the general medical wards. J Formos Med Assoc. 2012, 111:77-82.