Tolerability of high-dose baclofen in the treatment of patients with alcohol disorders: A retrospective study

Alcohol and Alcoholism

Volumn 50, Issue 5, 2015, Pages 551-557

  Rigal, Laurent ^a   Hoang, Léa Legay ^a   Alexandre Dubroeucq, Constance ^a   Pinot, Juliette ^a   Le Jeunne, Claire ^a   Jaury, Philippe ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACLOFEN; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT;

ADULT; ADVERSE OUTCOME; ALCOHOL CONSUMPTION; ALCOHOLISM; ALERTNESS; ARTHRALGIA; ARTICLE; ASTHENIA; CLINICAL ASSESSMENT; CONSTIPATION; CONTROLLED STUDY; DEPRESSION; DIARRHEA; DISEASE ASSOCIATION; DRUG ERUPTION; DRUG MEGADOSE; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSGEUSIA; FEMALE; GENERAL PRACTITIONER; HEADACHE; HOT FLUSH; HUMAN; HYPOMANIA; INSOMNIA; INTERVIEW; LIBIDO DISORDER; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MEMORY DISORDER; NAUSEA; OUTCOME ASSESSMENT; PARESTHESIA; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; RETROSPECTIVE STUDY; SIDE EFFECT; SLEEP PATTERN; SLEEP WAKING CYCLE; SOMNOLENCE; SWEATING; TIME TO TREATMENT; TINNITUS; UROGENITAL TRACT DISEASE; VERTIGO; CHEMICALLY INDUCED; DOSE RESPONSE; MIDDLE AGED; SLEEP WAKE DISORDERS; TREATMENT OUTCOME;

ADULT; ALCOHOLISM; BACLOFEN; DEPRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GABA-B RECEPTOR AGONISTS; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SLEEP WAKE DISORDERS; TREATMENT OUTCOME;

EID: 84954192690     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agv052     Document Type: Article

References (23)

1. Addolorato G, Caputo F, Capristo E, et al. (2002) Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study. Alcohol Alcohol 37:504-8.
2. Addolorato G, Leggio L, Ferrulli A, et al. (2007) Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study. Lancet 370:1915-22.
3. Addolorato G, Leggio L, Ferrulli A, et al. (2011) Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial. Alcohol Alcohol 46:312-7.
4. Ameisen O. (2005) Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician. Alcohol Alcohol 40:147-50.
5. BucknamW. (2007) Suppression of symptoms of alcohol dependence and craving using high-dose baclofen. Alcohol Alcohol 42:158-60.
6. Chen KS, Bullard MJ, Chien YY, et al. (1997) Baclofen toxicity in patients with severely impaired renal function. Ann Pharmacother 31:1315-20.
7. Comité technique de pharmacovigilance. (2013) Effets indésirables du baclofène dans le traitement des addictions - Suivi national de pharmacovigilance: année 2012: Centre régional de pharmacovigilance de Grenoble. de Beaurepaire R. (2012) Suppression of alcohol dependence using baclofen: a 2-year observational study of 100 patients. Front Psychiatry 3:103.
8. Dore GM, Lo K, Juckes L, et al. (2011) Clinical experience with baclofen in the management of alcohol-dependent patients with psychiatric comorbidity: a selected case series. Alcohol Alcohol 46:714-20.
9. Evans SM, Bisaga A. (2009) Acute interaction of baclofen in combination with alcohol in heavy social drinkers. Alc Clin Exp Res 33:19-30.
10. Gache P, de Beaurepaire R, Jaury P, et al. (2014) Prescribing Guide for Baclofen in the Treatment of Alcoholism for use by Physicians. B J Med&Med Res 4:1164-74.
11. Garbutt JC, Flannery B. (2007) Baclofen for alcoholism. Lancet 370:1884-5.
12. Garbutt JC, Kampov-Polevoy AB, Gallop R, et al. (2010) Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebocontrolled trial. Alc Clin Exp Res 34:1849-57.
13. Leggio L, Zywiak WH, McGeary JE, et al. (2013) A human laboratory pilot study with baclofen in alcoholic individuals. Pharmaco Biochem Behav 103:784-91.
14. Leo RJ, Baer D. (2005) Delirium associated with baclofen withdrawal: a review of common presentations and management strategies. Psychosomatics 46:503-7.
15. Leung NY, Whyte IM, Isbister GK. (2006) Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas 18:77-82.
16. Marsot A, Imbert B, Alvarez JC, et al. (2014) High variability in the exposure of baclofen in alcohol-dependent patients. Alcohol Clin Exp Res 38:316-21.
17. NICE. (2011) Interventions for Harmful Drinking and Alcohol Dependence. London: National Institute for Health and Care Excellence. http://www. nice.org.uk/guidance/cg115.
18. Pastor A, Jones DM, Currie J. (2012) High-dose baclofen for treatment-resistant alcohol dependence. J Clin Psychopharmacol 32:266-8.
19. Rigal L, Alexandre-Dubroeucq C, de Beaurepaire R, et al. (2012a) Abstinence and 'low-risk' consumption 1 year after the initiation of high-dose baclofen: a retrospective study among 'high-risk' drinkers. Alcohol Alcohol 47:439-42.
20. Rigal L, de Beaurepaire R, Le Jeunne C, et al. (2012b) Patient Protection: from Compassion and Pragmatism to Research: Reponse to Dr Braillon's Comments. Alcohol Alcohol 47:631-2.
21. Rolland B, Deheul S, Danel T, et al. (2012) A case of de novo seizures following a probable interaction of high-dose baclofen with alcohol. Alcohol Alcohol 47:577-80.
22. Smith CR, LaRocca NG, Giesser BS, et al. (1991) High-dose oral baclofen: experience in patients with multiple sclerosis. Neurology 41:1829-31.
23. WHO. (2000) International Guide for Monitoring Alcohol Consumption and Related Harm. Geneva: Departement of Mental Health and Substance Dependence Noncommunicable Diseases and Mental Health Cluster - World Health Organisation.