High Variability in the Exposure of Baclofen in Alcohol-Dependent Patients

Alcoholism: Clinical and Experimental Research

Volumn 38, Issue 2, 2014, Pages 316-321

  Marsot, Amélie ^a   Imbert, Bruce ^a   Alvarez, Jean Claude ^b   Grassin Delyle, Stanislas ^b   Jaquet, Isabelle ^a   Lançon, Christophe ^a   Simon, Nicolas ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b RAYMOND POINCARÉ HOSPITAL   (France)

Author keywords

Alcohol Dependent Patients; Baclofen; High Variability; Population Pharmacokinetics

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BACLOFEN; CARBOHYDRATE DEFICIENT TRANSFERRIN; CREATININE; GAMMA GLUTAMYLTRANSFERASE; UREA;

ADULT; AGED; ALCOHOL WITHDRAWAL; ALCOHOLISM; ARTICLE; BLOOD CLOTTING PARAMETERS; BODY HEIGHT; BODY WEIGHT; CLINICAL ARTICLE; COMPARTMENT MODEL; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXPOSURE; DRUG MONITORING; FAGERSTROM TEST FOR NICOTINE DEPENDENCE; FEMALE; GENDER; HUMAN; MALE; MIDDLE AGED; OUTPATIENT; PRIORITY JOURNAL; PROTHROMBIN RATIO; SMOKING; TOBACCO CONSUMPTION;

NICOTIANA TABACUM;

ALCOHOL-DEPENDENT PATIENTS; BACLOFEN; HIGH VARIABILITY; POPULATION PHARMACOKINETICS;

ADULT; AGED; ALCOHOLISM; ALGORITHMS; AREA UNDER CURVE; BACLOFEN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GABA AGONISTS; HUMANS; MALE; MIDDLE AGED; POPULATION; REGRESSION ANALYSIS;

EID: 84893647154     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12235     Document Type: Article

References (17)

1. Addolorato G, Leggio L, Ferrulli A, Cardone S, Vonghia L, Mirijello A, Abenavoli L, D'Angelo C, Caputo F, Zambon A, Haber PS, Gasbarrini G (2007) Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-bind controlled study. Lancet 370:1915-1922.
2. Aisen M, Dietz M, Rossi P, Cedarbaum J, Kutt H (1992) Clinical and pharmacokinetic aspects of high dose oral baclofen therapy. J Am Paraplegia Soc 15:211-216.
3. Anderson BJ, McKee AD, Holford NH (1997) Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients. Clin Pharmacokinet 33:313-327.
4. Beal S, Sheiner LB (1991) NONMEM Project Group. University of California, San Francisco, CA.
5. Comets E, Brendel K, Mentre F (2008) Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: the NPDE add-on package for R. Comput Methods Programs Biomed 90:154-166.
6. Evans SM, Bisaga A (2009) Acute interaction of baclofen in combination with alcohol in heavy social drinkers. Alcohol Clin Exp Res 33:19-30.
7. Flannery BA, Garbutt JC, Cody MW, Renn W, Grace K, Osborne M, Crosby K, Morreale M, Trivette A (2008) Baclofen for alcohol dependence: a preliminary open-label study. Alcohol Clin Exp Res 28:1517-1523.
8. Grant KA, Lovinger DM (1995) Cellular and behavioral neurobiology of alcohol: receptor-mediated neuronal processes. Clin Neurosci 3:155-164.
9. Heilig M, Egli M (2006) Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol Ther 111:855-876.
10. Johnson BA, Swift RM, Addolorato G, Ciraulo DA, Myrick H (2005) Safety and efficacy of GABAergic medications for treating alcoholism. Alcohol Clin Exp Res 29:248-254.
11. Kochak GM, Rakhit A, Wagner WE, Honc F, Waldes L, Kershaw RA (1985) The pharmacokinetics of baclofen derived from intestinal infusion. Clin Pharmacol Ther 38:251-257.
12. Muzyk AJ, Rivelli SK, Gagliardi JP (2012) Defining the role of baclofen for the treatment of alcohol dependence. CNS Drugs 26:69-78.
13. Pastor A, Jones DML, Currie J (2012) High-dose baclofen for treatment-resistant alcohol dependence. J Clin Psychopharmacol 32:266-268.
14. Rigal L, Alexandre-Dubroeucq C, de Beaurepaire R, Le Jeunne C, Jaury P (2012) Abstinence and 'low-risk' consumption 1 year after the initiation of high-dose baclofen: a retrospective study among 'high-risk' drinkers. Alcohol Alcohol 47:439-442.
15. West GB, Brown JH, Enquist BJ (1999) The fourth dimension of life: fractal geometry and allometric scaling of organisms. Science 284:1677-1679.
16. Wuis EW, Dirks MJM, Termond EFS, Vree TB, Kleijn E (1989) Plasma and urinary excretion kinetics of oral baclofen in healthy subjects. Eur J Clin Pharmacol 37:181-184.
17. Wuis EW, Dirks MJ, Vree TB, Van der Kleijn E (1990) Pharmacokinetics of baclofen in spastic patients receiving multiple oral doses. Pharm Weekbl Sci 12:71-74.