Clinical experience with baclofen in the management of alcohol-dependent patients with psychiatric comorbidity: A selected case series

Alcohol and Alcoholism

Volumn 46, Issue 6, 2011, Pages 714-720

  Dore, G M ^a,b   Lo, K ^a,c   Juckes, L ^a,b   Bezyan, S ^a   Latt, N ^a,b  

^a Northern Sydney Drug and Alcohol Service   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c The New South Wales Institute of Psychiatry   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACAMPROSATE; ALCOHOL; ALPRAZOLAM; BACLOFEN; BUPRENORPHINE; CENTRAL DEPRESSANT AGENT; DIAZEPAM; DISULFIRAM; METHADONE; METHAMPHETAMINE; MIANSERIN; NALTREXONE; VENLAFAXINE;

ADULT; AGORAPHOBIA; ALCOHOL ABSTINENCE; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; ATAXIA; BACKACHE; CASE STUDY; CLINICAL ARTICLE; COGNITIVE THERAPY; COMORBIDITY; DEPRESSION; DETOXIFICATION; DISORIENTATION; DIZZINESS; DRUG DOSE ESCALATION; DRUG DOSE TITRATION; DRUG EFFECT; DRUG OVERDOSE; DRUG WITHDRAWAL; FATIGUE; FEMALE; FOLLOW UP; HEPATITIS C; HUMAN; INCONTINENCE; MALE; MENTAL DISEASE; OUTPATIENT CARE; PANIC; PERSONALITY DISORDER; PRIORITY JOURNAL; PSYCHIATRIC TREATMENT; PSYCHOPHARMACOTHERAPY; SEDATION; SIDE EFFECT; SOMNOLENCE; SUICIDAL BEHAVIOR; TREATMENT OUTCOME; WITHDRAWAL SYNDROME;

ADULT; ALCOHOLISM; ANXIETY DISORDERS; BACLOFEN; DEPRESSIVE DISORDER; FEMALE; GABA-B RECEPTOR AGONISTS; HUMANS; MALE; MIDDLE AGED; OUTPATIENTS; RETROSPECTIVE STUDIES;

EID: 80054953461     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agr131     Document Type: Article

References (46)

1. Addolorato G, Caputo F, Esmeralda C et al. (2002) Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study. Alcohol Alcohol 37:504-8.
2. Addolorato G, Leggio L, Ferruli A et al. (2007) Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomized, double-blind controlled study. Lancet 370:1915-22.
3. Addolorato G, Leggio L, Ferruli A et al. (2011) Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial. Alcohol Alcohol 46:312-7.
4. Agabio R, Marras P, Addolorato G et al. (2007) Baclofen suppresses alcohol intake and craving for alcohol in a schizophrenic alcohol-dependent patient: a case report. J Clin Psychopharmacol 27:319-20.
5. Ameisen O. (2005) Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician. Alcohol Alcohol 40:147-50.
6. Bouza C, Magro A, Muñoz A et al. (2004) Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review. Addiction 99:811-28.
7. Breslow MF, Fankhauser MP, Potter RL et al. (1989) Role of γ-aminobutyric acid in antipanic drug efficacy. Am J Psychiatry 146:353-6.
8. Brown ES, Beard L, Dobbs L et al. (2006) Naltrexone in patients with bipolar disorder and alcohol dependence. Depress Anxiety 23:492-5.
9. Brown ES, Carmody TJ, Schmitz JM et al. (2009) A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence. Alcohol Clin Exp Res 33:1-7.
10. Bucknam W. (2007) Suppression of symptoms of alcohol dependence and craving using high-dose baclofen. Alcohol Alcohol 42:158-60.
11. Chawla JM, Sagar R. (2006) Baclofen-induced psychosis. Ann Pharmacother 40:2071-3.
12. Colombo G, Addolorato G, Agabio R et al. (2004) Role of GABAB receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res 6:403-14.
13. Cornelius JR, Bukstein O, Salloum I et al. (2003) Alcohol and psychiatric comorbidity. Recent Dev Alcohol 16: 361-74.
14. Dario A, Tomei G. (2004) A benefit-risk assessment of baclofen in severe spinal spasticity. Drug Saf 27:799-818.
15. Drake RG, Davis LL, Cates ME et al. (2003) Baclofen treatment for chronic post traumatic stress disorder. Ann of Pharmacother 37:1177-81.
16. Evans SM, Bisaga A. (2009) Acute interaction of baclofen in combination with alcohol in heavy social drinkers. Alcohol Clin Exp Res 33:19-30.
17. Garbutt J, Kampov-Polevoy AB, Gallop R et al. (2010) Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial. Alcohol Clin Exp Res 34:1849-57.
18. Jones RF, Lance JW. (1976) Baclofen (Lioresal) in the long-term management of spasticity. Med J of Aust 1:654-7.
19. Kessler RC, McGonagle KA, Zhao S et al. (1994) Lifetime and twelve month prevalence of DSM-III-R psychiatric disorders in the United States: results from the National Comorbidity Survey. Arch Gen Psychiatry 51:8-19.
20. Krupitsky EM, Burakov AM, Ivanov VB et al. (1993) Baclofen administration for the treatment of affective disorders in alcoholic patients. Drug Alcohol Depend 33:157-63.
21. Latt NC, Jurd S, Houseman J et al. (2002) Naltrexone in alcohol dependence: a randomised controlled trial of effectiveness in a standard clinical setting. Med J Aust 176:530-4.
22. Leo RJ, Baer D. (2005) Delirium associated with baclofen withdrawal: a review of common presentations and management strategies. Psychosomatics 46:503-7.
23. Leung NY, Whyte IM, Isbister GK. (2006) Baclofen overdose, defining the spectrum of toxicity. Emerg Med Australas 18:77-82.
24. May CR. (1983) Baclofen overdose. Ann Emerg Med 12:171-3.
25. Murphy GE, Wetzel RD, Robins E et al. (1992) Multiple risk factors predict suicide in alcoholism. Arch Gen Psychiatry 49:459-63.
26. Nasti JJ, Brakoulias V. (2011) Chronic baclofen abuse and withdrawal. Aust NZ J Psychiatry 45:86-7.
27. O'Sullivan K, Rynne C, Miller J et al. (1988) A follow-up study on alcoholics with and without co-existing affective disorder. Br J Psychiatry 152:813-9.
28. Pauker SL, Brown R. (1986) Baclofen-induced catatonia. J Clin Psychopharmacol 6:387-8.
29. Perry HE, Wright RO, Shannon MW et al. (1998) Baclofen overdose: drug experimentation in a group of adolescents. Pediatrics 101:1045-8.
30. Petrakis IL, Poling J, Levinson C et al. (2005) Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disorders. Biol Psychiatry 57:1128-37.
31. Pettinati HM, Oslin DW, Kampman KM et al. (2010) A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence. Am J Psychiatry 167:668-75.
32. Regier DA, Farmer ME, Rae DS et al. (1990) Comorbidity of mental disorders with alcohol and other drug abuse: results from the Epidemiologic Catchment Area (ECA) Study. JAMA 264:1511-8.
33. Rossi S. (2010) Australian Medicines Handbook. Adelaide: Australian Medicines Handbook Pty Ltd.
34. Rounsaville BJ, Dolinsky ZS, Babor TF et al. (1987) Psychopathology as a predictor of treatment outcome in alcoholics. Arch Gen Psychiatry 44:505-13.
35. Roy CW, Wakefield IR. (1986) Baclofen pseudopsychosis: case report. Paraplegia 24:318-21.
36. Salloum IM, Cornelius JR, Chakravorthy S. (2003) Combined naltrexone valproate in bipolar alcoholics: a randomized, openlabel, pilot study. Bipolar Disord 5(Suppl. 1):79-80.
37. Sandyk R, Gillman MA. (1984) Hemifacial spasm-successful treatment with baclofen (letter). S Afr Med J 65:502.
38. Skausig OB, Korsgaard S. (1977) Hallucinations and baclofen. Lancet 54:1258.
39. Smith CR, LaRocca NG, Giesser BS et al. (1991) High-dose oral baclofen: experience in patients with multiple sclerosis. Neurology 41:1829-31.
40. Sommer BR, Petrides G. (1992) A case of baclofen-induced psychotic depression (letter). J Clin Psychiatry 53:211-2.
41. Terrence CF, Fromm GH. (1981) Complications of baclofen withdrawal. Arch Neurol 38:588-9.
42. Tolliver BK, McRae A, Sonne SC et al. (2009) Safety and tolerability of acamprosate in alcohol-dependent individuals with bipolar disorder: an open-label pilot study. Add Dis Their Treatment 8:33-8.
43. Van Dierendonk DR, Dire DJ. (1999) Baclofen and ethanol ingestion: a case report. J Emerg Med 17:989-93.
44. Wall GC, Wasiak A, Hicklin GA. (2006) An initially unsuspected case of baclofen overdose. Am J Crit Care 15:611-3.
45. Wolf ME, Almy G, Toll M et al. (1982) Mania associated with the use of baclofen. Biol Psychiatry 17:757-9.
46. Yassa RY, Iskandar HL. (1988) Baclofen-induced psychosis: two cases and a review. J Clin Psychiatry 49:318-20.