ANRIL: a pivotal tumor suppressor long non-coding RNA in human cancers

Tumor Biology

Volumn 37, Issue 5, 2016, Pages 5657-5661

  Li, Zheng ^a   Yu, Xin ^a   Shen, Jianxiong ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

ANRIL; Cancer; lncRNAs; Long non coding RNAs

Indexed keywords

LONG UNTRANSLATED RNA; PROTEIN ANRIL; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; ANRIL LONG NON-CODING RNA, HUMAN; RNA; TUMOR MARKER;

APOPTOSIS; BLADDER CANCER; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; HUMAN; LIVER CELL CARCINOMA; LUNG CANCER; LYMPHATIC LEUKEMIA; MALIGNANT NEOPLASTIC DISEASE; MELANOMA; NEUROFIBROMATOSIS; OVARY CANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; STOMACH CANCER; UTERINE CERVIX CANCER; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; HEREDITARY TUMOR SYNDROME; NEOPLASM; NEUROFIBROMATOSIS TYPE 1; PATHOLOGY; TUMOR INVASION; TUMOR SUPPRESSOR GENE;

APOPTOSIS; BIOMARKERS, TUMOR; CELL MOVEMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; NEOPLASM INVASIVENESS; NEOPLASMS; NEOPLASTIC SYNDROMES, HEREDITARY; NEUROFIBROMATOSIS 1; RNA, LONG NONCODING; RNA, NEOPLASM;

EID: 84954114277     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-016-4808-5     Document Type: Review

References (52)

1. Gibb EA, Brown CJ, Lam WL. The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 2011;10:38.
2. Wan X, Ding X, Chen S, Song H, Jiang H, Fang Y, et al. The functional sites of miRNAs and lncRNAs in gastric carcinogenesis. Tumour Biol. 2015;36:521–32.
3. Tano K, Akimitsu N. Long non-coding RNAs in cancer progression. Front Genet. 2012;3:219.
4. Li CH, Chen Y. Targeting long non-coding RNAs in cancers: progress and prospects. Int J Biochem Cell Biol. 2013;45:1895–910.
5. Kitagawa M, Kotake Y, Ohhata T. Long non-coding RNAs involved in cancer development and cell fate determination. Curr Drug Targets. 2012;13:1616–21.
6. Gutschner T, Diederichs S. The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol. 2012;9:703–19.
7. Taylor DH, Chu ET, Spektor R, Soloway PD. Long non-coding RNA regulation of reproduction and development. Mol Reprod Dev. 2015. doi:10.1002/mrd.22581.
8. Yang Y, Wen L, Zhu H. Unveiling the hidden function of long non-coding RNA by identifying its major partner-protein. Cell Biosci. 2015;5:59.
9. Yu X, Li Z. The role of miRNAs in cutaneous squamous cell carcinoma. J Cell Mol Med. 2015. doi:10.1111/jcmm.12649.
10. Li Z, Yu X, Shen J. The role of miRNAs in the pheochromocytomas. Tumour Biol. 2015. doi:10.1007/s13277-015-4199-z.
11. Yu X, Li Z. MicroRNA expression and its implications for diagnosis and therapy of tongue squamous cell carcinoma. J Cell Mol Med. 2015. doi:10.1111/jcmm.12650.
12. Li Z, Yu X, Shen J, Jiang Y. MicroRNA dysregulation in uveal melanoma: a new player enters the game. Oncotarget. 2015;6:4562–8.
13. Yu X, Li Z. Long non-coding RNA growth arrest-specific transcript 5 in tumor biology. Oncol Lett. 2015;10:1953–8.
14. Yu X, Li Z. Long non-coding RNA HOTAIR: a novel oncogene (review). Mol Med Rep. 2015;12:5611–8.
15. Silva A, Bullock M, Calin G. The clinical relevance of long non-coding RNAs in cancer. Cancers. 2015;7:2169–82.
16. Wang G, Liu C, Deng S, Zhao Q, Li T, Qiao S, et al. Long noncoding rnas in regulation of human breast cancer. Brief Funct Genomics. 2015. doi:10.1093/bfgp/elv049.
17. Tao H, Yang JJ, Zhou X, Deng ZY, Shi KH, Li J. Emerging role of long non-coding RNAs in lung cancer: current status and future prospects. Respir Med. 2015;110:12–9.
18. Meseure D, Drak Alsibai K, Nicolas A, Bieche I, Morillon A. Long non-coding RNAs as new architects in cancer epigenetics, prognostic biomarkers, and potential therapeutic targets. Biomed Res Int. 2015;2015:320214.
19. Shahryari A, Jazi MS, Samaei NM, Mowla SJ. Long non-coding RNA SOX2OT: expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesis. Front Genet. 2015;6:196.
20. Ding X, Wan X, Jiang H, Song H, Fang Y, Chen S, et al. The clinical value of ncRNAs in gastric cancer: a systematic review and meta-analyses. Tumour Biol. 2015;36:4017–25.
21. Hajjari M, Salavaty A. HOTAIR: an oncogenic long non-coding RNA in different cancers. Cancer Biol Med. 2015;12:1–9.
22. Yang X, Xie X, Xiao YF, Xie R, Hu CJ, Tang B, et al. The emergence of long non-coding RNAs in the tumorigenesis of hepatocellular carcinoma. Cancer Lett. 2015;360:119–24.
23. Martens-Uzunova ES, Bottcher R, Croce CM, Jenster G, Visakorpi T, Calin GA. Long non-coding RNA in prostate, bladder, and kidney cancer. Eur Urol. 2014;65:1140–51.
24. Yarmishyn AA, Kurochkin IV. Long non-coding RNAs: a potential novel class of cancer biomarkers. Front Genet. 2015;6:145.
25. Di Gesualdo F, Capaccioli S, Lulli M. A pathophysiological view of the long non-coding RNA world. Oncotarget. 2014;5:10976–96.
26. Pasmant E, Laurendeau I, Heron D, Vidaud M, Vidaud D, Bieche I. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense non-coding RNA whose expression coclusters with ARF. Cancer Res. 2007;67:3963–9.
27. Zhang EB, Kong R, Yin DD, You LH, Sun M, Han L, et al. Long non-coding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of mir-99a/mir-449a. Oncotarget. 2014;5:2276–92.
28. Iranpour M, Soudyab M, Geranpayeh L, Mirfakhraie R, Azargashb E, Movafagh A, et al. Expression analysis of four long non-coding RNAs in breast cancer. Tumour Biol. 2015. doi:10.1007/s13277-015-4135-2.
29. Naemura M, Murasaki C, Inoue Y, Okamoto H, Kotake Y. Long non-coding RNA ANRIL regulates proliferation of non-small-cell lung cancer and cervical cancer cells. Anticancer Res. 2015;35:5377–82.
30. Zhu H, Li X, Song Y, Zhang P, Xiao Y, Xing Y. Long non-coding RNA ANRIL is upregulated in bladder cancer and regulates bladder cancer cell proliferation and apoptosis through the intrinsic pathway. Biochem Biophys Res Commun. 2015;467:223–8.
31. Kia SK, Gorski MM, Giannakopoulos S, Verrijzer CP. SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. Mol Cell Biol. 2008;28:3457–64.
32. Gil J, Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol. 2006;7:667–77.
33. Ozenne P, Eymin B, Brambilla E, Gazzeri S. The ARF tumor suppressor: structure, functions and status in cancer. Int J Cancer. 2010;127:2239–47.
34. Kheradmand Kia S, Solaimani Kartalaei P, Farahbakhshian E, Pourfarzad F, von Lindern M, Verrijzer CP. EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence. Epigenetics Chromatin. 2009;2:16.
35. Yap KL, Li S, Munoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, et al. Molecular interplay of the non-coding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell. 2010;38:662–74.
36. Aguilo F, Di Cecilia S, Walsh MJ. Long non-coding RNA ANRIL and polycomb in human cancers and cardiovascular disease. Curr Top Microbiol Immunol. 2015. doi:10.1007/82_2015_455.
37. He S, Gu W, Li Y, Zhu H. ANRIL/CDKN2B-AS shows two-stage clade-specific evolution and becomes conserved after transposon insertions in simians. BMC Evol Biol. 2013;13:247.
38. Aguilo F, Zhou MM, Walsh MJ. Long non-coding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression. Cancer Res. 2011;71:5365–9.
39. Kotake Y, Nakagawa T, Kitagawa K, Suzuki S, Liu N, Kitagawa M, et al. Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4b) tumor suppressor gene. Oncogene. 2011;30:1956–62.
40. Rodriguez C, Borgel J, Court F, Cathala G, Forne T, Piette J. CTCF is a DNA methylation-sensitive positive regulator of the INK/ARF locus. Biochem Biophys Res Commun. 2010;392:129–34.
41. Nie FQ, Sun M, Yang JS, Xie M, Xu TP, Xia R, et al. Long non-coding RNA ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and p21 expression. Mol Cancer Ther. 2015;14:268–77.
42. Lin L, Gu ZT, Chen WH, Cao KJ. Increased expression of the long non-coding RNA ANRIL promotes lung cancer cell metastasis and correlates with poor prognosis. Diagn Pathol. 2015;10:14.
43. Kang YH, Kim D, Jin EJ. Down-regulation of phospholipase d stimulates death of lung cancer cells involving upregulation of the long ncRNA anril. Anticancer Res. 2015;35:2795–803.
44. Huang MD, Chen WM, Qi FZ, Xia R, Sun M, Xu TP, et al. Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell apoptosis by epigenetic silencing of klf2. J Hematol Oncol. 2015;8:50.
45. Hua L, Wang CY, Yao KH, Chen JT, Zhang JJ, Ma WL. High expression of long non-coding RNA ANRIL is associated with poor prognosis in hepatocellular carcinoma. Int J Clin Exp Pathol. 2015;8:3076–82.
46. Chen D, Zhang Z, Mao C, Zhou Y, Yu L, Yin Y, et al. ANRIL inhibits p15(INK4b) through the TGF beta 1 signaling pathway in human esophageal squamous cell carcinoma. Cell Immunol. 2014;289:91–6.
47. Kang M, Sang Y, Gu H, Zheng L, Wang L, Liu C, et al. Long non-coding RNAs POLR2Ee rs3787016 c/t and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer. Tumour Biol. 2015;36:6401–8.
48. Martinez-Fernandez M, Feber A, Duenas M, Segovia C, Rubio C, Fernandez M, et al. Analysis of the polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer. Clin Epigenetics. 2015;7:109.
49. Qiu JJ, Lin YY, Ding JX, Feng WW, Jin HY, Hua KQ. Long non-coding RNA ANRIL predicts poor prognosis and promotes invasion/metastasis in serous ovarian cancer. Int J Oncol. 2015;46:2497–505.
50. Iacobucci I, Sazzini M, Garagnani P, Ferrari A, Boattini A, Lonetti A, et al. A polymorphism in the chromosome 9p21 ANRIL locus is associated to Philadelphia positive acute lymphoblastic leukemia. Leuk Res. 2011;35:1052–9.
51. Pasmant E, Sabbagh A, Masliah-Planchon J, Ortonne N, Laurendeau I, Melin L, et al. Role of non-coding RNA ANRIL in genesis of plexiform neurofibromas in neurofibromatosis type 1. J Natl Cancer Inst. 2011;103:1713–22.
52. Mussotter T, Kluwe L, Hogel J, Nguyen R, Cooper DN, Mautner VF, et al. Non-coding RNA ANRIL and the number of plexiform neurofibromas in patients with NF1 microdeletions. BMC Med Genet. 2012;13:98.