메뉴 건너뛰기




Volumn 90, Issue 1, 2016, Pages 356-367

The missing link in Epstein-Barr virus immune evasion: The BDLF3 gene induces ubiquitination and downregulation of major histocompatibility complex class I (MHC-I) and MHC-II

Author keywords

[No Author keywords available]

Indexed keywords

BILF1 PROTEIN; CD71 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEASOME; PROTEIN BDLF3; UNCLASSIFIED DRUG; VIRUS PROTEIN; BDLF-3 PROTEIN, HUMAN HERPESVIRUS 4; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; MEMBRANE PROTEIN; VIRAL PROTEIN;

EID: 84953911375     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02183-15     Document Type: Article
Times cited : (60)

References (49)
  • 1
    • 34249064632 scopus 로고    scopus 로고
    • Epstein-Barr virus
    • Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE (ed), 5th ed Lippincott Williams & Wilkins, Philadelphia, PA
    • Rickinson AB, KieffE. 2007. Epstein-Barr virus, p 2655-2700. In Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE (ed), Fields virology, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
    • (2007) Fields virology , pp. 2655-2700
    • Rickinson, A.B.1    Kieff, E.2
  • 2
    • 56949100257 scopus 로고    scopus 로고
    • Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products
    • Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ. 2008. Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products. Semin Cancer Biol 18:397-408. http://dx.doi.org/10.1016/j.semcancer.2008.10.008.
    • (2008) Semin Cancer Biol , vol.18 , pp. 397-408
    • Ressing, M.E.1    Horst, D.2    Griffin, B.D.3    Tellam, J.4    Zuo, J.5    Khanna, R.6    Rowe, M.7    Wiertz, E.J.8
  • 3
    • 76549087625 scopus 로고    scopus 로고
    • Immune responses to Epstein-Barr virus: molecular interactions in the virus evasion of CD8+T cell immunity
    • Rowe M, Zuo J. 2010. Immune responses to Epstein-Barr virus: molecular interactions in the virus evasion of CD8+T cell immunity. Microbes Infect 12:173-181. http://dx.doi.org/10.1016/j.micinf.2009.12.001.
    • (2010) Microbes Infect , vol.12 , pp. 173-181
    • Rowe, M.1    Zuo, J.2
  • 6
    • 0030881322 scopus 로고    scopus 로고
    • Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10
    • Zeidler R, Eissner G, Meissner P, Uebel S, Tampe R, Lazis S, Hammer-schmidt W. 1997. Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10. Blood 90:2390-2397.
    • (1997) Blood , vol.90 , pp. 2390-2397
    • Zeidler, R.1    Eissner, G.2    Meissner, P.3    Uebel, S.4    Tampe, R.5    Lazis, S.6    Hammer-schmidt, W.7
  • 7
    • 59249101973 scopus 로고    scopus 로고
    • The Epstein-Barr virus G-proteincoupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation
    • Zuo J, Currin A, Griffin BD, Shannon-Lowe C, Thomas WA, Ressing ME, Wiertz EJ, Rowe M. 2009. The Epstein-Barr virus G-proteincoupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation. PLoS Pathog 5:e1000255. http://dx.doi.org/10.1371/journal.ppat.1000255.
    • (2009) PLoS Pathog , vol.5
    • Zuo, J.1    Currin, A.2    Griffin, B.D.3    Shannon-Lowe, C.4    Thomas, W.A.5    Ressing, M.E.6    Wiertz, E.J.7    Rowe, M.8
  • 12
    • 78951479559 scopus 로고    scopus 로고
    • The Epstein-Barr virus-encoded BILF1 protein modulates immune recognition of endogenously processed antigen by targeting major histocompatibility complex class I molecules trafficking on both the exocytic and endocytic pathways
    • Zuo J, Quinn LL, Tamblyn J, Thomas WA, Feederle R, Delecluse HJ, Hislop AD, Rowe M. 2011. The Epstein-Barr virus-encoded BILF1 protein modulates immune recognition of endogenously processed antigen by targeting major histocompatibility complex class I molecules trafficking on both the exocytic and endocytic pathways. J Virol 85:1604-1614. http://dx.doi.org/10.1128/JVI.01608-10.
    • (2011) J Virol , vol.85 , pp. 1604-1614
    • Zuo, J.1    Quinn, L.L.2    Tamblyn, J.3    Thomas, W.A.4    Feederle, R.5    Delecluse, H.J.6    Hislop, A.D.7    Rowe, M.8
  • 13
    • 84873564255 scopus 로고    scopus 로고
    • EBV BILF1 evolved to downregulate cell surface display of a wide range of HLA class I molecules through their cytoplasmic tail
    • Griffin BD, Gram AM, Mulder A, Van Leeuwen D, Claas FH, Wang F, Ressing ME, Wiertz E. 2013. EBV BILF1 evolved to downregulate cell surface display of a wide range of HLA class I molecules through their cytoplasmic tail. J Immunol 190:1672-1684. http://dx.doi.org/10.4049/jimmunol.1102462.
    • (2013) J Immunol , vol.190 , pp. 1672-1684
    • Griffin, B.D.1    Gram, A.M.2    Mulder, A.3    Van Leeuwen, D.4    Claas, F.H.5    Wang, F.6    Ressing, M.E.7    Wiertz, E.8
  • 15
    • 61449138716 scopus 로고    scopus 로고
    • Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation
    • Horst D, van Leeuwen D, Croft NP, Garstka MA, Hislop AD, Kremmer E, Rickinson AB, Wiertz EJ, Ressing ME. 2009. Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation. J Immunol 182:2313-2324. http://dx.doi.org/10.4049/jimmunol.0803218.
    • (2009) J Immunol , vol.182 , pp. 2313-2324
    • Horst, D.1    van Leeuwen, D.2    Croft, N.P.3    Garstka, M.A.4    Hislop, A.D.5    Kremmer, E.6    Rickinson, A.B.7    Wiertz, E.J.8    Ressing, M.E.9
  • 16
    • 84927668370 scopus 로고    scopus 로고
    • Cooperation between Epstein-Barr virus immune evasion proteins spreads protection from CD8+T cell recognition across all three phases of the lytic cycle
    • Quinn LL, Zuo J, Abbott RJ, Shannon-Lowe C, Tierney RJ, Hislop AD, Rowe M. 2014. Cooperation between Epstein-Barr virus immune evasion proteins spreads protection from CD8+T cell recognition across all three phases of the lytic cycle. PLoS Pathog 10:e1004322. http://dx.doi.org/10.1371/journal.ppat.1004322.
    • (2014) PLoS Pathog , vol.10
    • Quinn, L.L.1    Zuo, J.2    Abbott, R.J.3    Shannon-Lowe, C.4    Tierney, R.J.5    Hislop, A.D.6    Rowe, M.7
  • 17
    • 13644262179 scopus 로고    scopus 로고
    • CD8+ immunodominance among Epstein-Barr virus lytic cycle antigens directly reflects the efficiency of antigen presentation in lytically infected cells
    • Pudney VA, Leese AM, Rickinson AB, Hislop AD. 2005. CD8+ immunodominance among Epstein-Barr virus lytic cycle antigens directly reflects the efficiency of antigen presentation in lytically infected cells. J Exp Med 201:349-360. http://dx.doi.org/10.1084/jem.20041542.
    • (2005) J Exp Med , vol.201 , pp. 349-360
    • Pudney, V.A.1    Leese, A.M.2    Rickinson, A.B.3    Hislop, A.D.4
  • 18
    • 0031821276 scopus 로고    scopus 로고
    • Epstein-Barr virus recombinant lacking expression of glycoprotein gp150 infects B cells normally but is enhanced for infection of epithelial cells
    • Borza CM, Hutt-Fletcher LM. 1998. Epstein-Barr virus recombinant lacking expression of glycoprotein gp150 infects B cells normally but is enhanced for infection of epithelial cells. J Virol 72:7577-7582.
    • (1998) J Virol , vol.72 , pp. 7577-7582
    • Borza, C.M.1    Hutt-Fletcher, L.M.2
  • 19
    • 0029037298 scopus 로고
    • A novel Epstein-Barr virus glycoprotein gp150 expressed from the BDLF3 open reading frame
    • Kurilla MG, Heineman T, Davenport LC, KieffE, Hutt-Fletcher LM. 1995. A novel Epstein-Barr virus glycoprotein gp150 expressed from the BDLF3 open reading frame. Virology 209:108-121. http://dx.doi.org/10.1006/viro.1995.1235.
    • (1995) Virology , vol.209 , pp. 108-121
    • Kurilla, M.G.1    Heineman, T.2    Davenport, L.C.3    Kieff, E.4    Hutt-Fletcher, L.M.5
  • 20
    • 0029014537 scopus 로고
    • The Epstein-Barr virus open reading frame BDLF3 codes for a 100-150 kDa glycoprotein
    • Nolan LA, Morgan AJ. 1995. The Epstein-Barr virus open reading frame BDLF3 codes for a 100-150 kDa glycoprotein. J Gen Virol 76:1381-1392. http://dx.doi.org/10.1099/0022-1317-76-6-1381.
    • (1995) J Gen Virol , vol.76 , pp. 1381-1392
    • Nolan, L.A.1    Morgan, A.J.2
  • 21
    • 76649105133 scopus 로고    scopus 로고
    • Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display
    • Leung CS, Haigh TA, Mackay LK, Rickinson AB, Taylor GS. 2010. Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display. Proc Natl Acad Sci U S A 107:2165-2170. http://dx.doi.org/10.1073/pnas.0909448107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 2165-2170
    • Leung, C.S.1    Haigh, T.A.2    Mackay, L.K.3    Rickinson, A.B.4    Taylor, G.S.5
  • 22
    • 0019840456 scopus 로고
    • Surface antigens of human melanoma cells defined by monoclonal antibodies. I. Biochemical characterization of two antigens found on cell lines and fresh tumors of diverse tissue origin
    • Johnson JP, Demmer-Dieckmann M, Meo T, Hadam MR, Riethmuller G. 1981. Surface antigens of human melanoma cells defined by monoclonal antibodies. I. Biochemical characterization of two antigens found on cell lines and fresh tumors of diverse tissue origin. Eur J Immunol 11:825-831.
    • (1981) Eur J Immunol , vol.11 , pp. 825-831
    • Johnson, J.P.1    Demmer-Dieckmann, M.2    Meo, T.3    Hadam, M.R.4    Riethmuller, G.5
  • 25
    • 0019413925 scopus 로고
    • Spontaneous release of a factor with properties of T cell growth factor from a continuous line of primate tumor T cells
    • Rabin H, Hopkins RF, III, Ruscetti FW, Neubauer RH, Brown RL, Kawakami TG. 1981. Spontaneous release of a factor with properties of T cell growth factor from a continuous line of primate tumor T cells. J Immunol 127:1852-1856.
    • (1981) J Immunol , vol.127 , pp. 1852-1856
    • Rabin, H.1    Hopkins, R.F.2    Ruscetti, F.W.3    Neubauer, R.H.4    Brown, R.L.5    Kawakami, T.G.6
  • 26
    • 0018154865 scopus 로고
    • Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis
    • Barnstable CJ, Bodmer WF, Brown G, Galfre G, Milstein C, Williams AF, Ziegler A. 1978. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis. Cell 14:9-20. http://dx.doi.org/10.1016/0092-8674(78)90296-9.
    • (1978) Cell , vol.14 , pp. 9-20
    • Barnstable, C.J.1    Bodmer, W.F.2    Brown, G.3    Galfre, G.4    Milstein, C.5    Williams, A.F.6    Ziegler, A.7
  • 28
    • 61449105702 scopus 로고    scopus 로고
    • Down-regulation of MHC class II expression through inhibition of CIITA transcription by lytic transactivator Zta during Epstein-Barr virus reactivation
    • Li D, Qian L, Chen C, Shi M, Yu M, Hu M, Song L, Shen B, Guo N. 2009. Down-regulation of MHC class II expression through inhibition of CIITA transcription by lytic transactivator Zta during Epstein-Barr virus reactivation. J Immunol 182:1799-1809. http://dx.doi.org/10.4049/jimmunol.0802686.
    • (2009) J Immunol , vol.182 , pp. 1799-1809
    • Li, D.1    Qian, L.2    Chen, C.3    Shi, M.4    Yu, M.5    Hu, M.6    Song, L.7    Shen, B.8    Guo, N.9
  • 29
    • 84877357964 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-encoded viral IRF3 modulates major histocompatibility complex class II (MHC-II) antigen presentation through MHC-II transactivator-dependent and-independent mechanisms: implications for oncogenesis
    • Zuo J, Hislop AD, Leung CS, Sabbah S, Rowe M. 2013. Kaposi's sarcoma-associated herpesvirus-encoded viral IRF3 modulates major histocompatibility complex class II (MHC-II) antigen presentation through MHC-II transactivator-dependent and-independent mechanisms: implications for oncogenesis. J Virol 87:5340-5350. http://dx.doi.org/10.1128/JVI.00250-13.
    • (2013) J Virol , vol.87 , pp. 5340-5350
    • Zuo, J.1    Hislop, A.D.2    Leung, C.S.3    Sabbah, S.4    Rowe, M.5
  • 32
    • 0034608951 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display ofMHCclass I chains by enhancing their endocytosis
    • Coscoy L, Ganem D. 2000. Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display ofMHCclass I chains by enhancing their endocytosis. Proc Natl Acad Sci U S A 97:8051-8056. http://dx.doi.org/10.1073/pnas.140129797.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 8051-8056
    • Coscoy, L.1    Ganem, D.2
  • 33
    • 0034068631 scopus 로고    scopus 로고
    • Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins
    • Ishido S, Wang C, Lee BS, Cohen GB, Jung JU. 2000. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins. J Virol 74:5300-5309. http://dx.doi.org/10.1128/JVI.74.11.5300-5309.2000.
    • (2000) J Virol , vol.74 , pp. 5300-5309
    • Ishido, S.1    Wang, C.2    Lee, B.S.3    Cohen, G.B.4    Jung, J.U.5
  • 35
    • 0035022210 scopus 로고    scopus 로고
    • Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8
    • Haque M, Ueda K, Nakano K, Hirata Y, Parravicini C, Corbellino M, Yamanishi K. 2001. Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8. J Gen Virol 82:1175-1180. http://dx.doi.org/10.1099/0022-1317-82-5-1175.
    • (2001) J Gen Virol , vol.82 , pp. 1175-1180
    • Haque, M.1    Ueda, K.2    Nakano, K.3    Hirata, Y.4    Parravicini, C.5    Corbellino, M.6    Yamanishi, K.7
  • 36
    • 26244468727 scopus 로고    scopus 로고
    • Downregulation of cell surface receptors by the K3 family of viral and cellular ubiquitin E3 ligases
    • Lehner PJ, Hoer S, Dodd R, Duncan LM. 2005. Downregulation of cell surface receptors by the K3 family of viral and cellular ubiquitin E3 ligases. Immunol Rev 207:112-125. http://dx.doi.org/10.1111/j.0105-2896.2005.00314.x.
    • (2005) Immunol Rev , vol.207 , pp. 112-125
    • Lehner, P.J.1    Hoer, S.2    Dodd, R.3    Duncan, L.M.4
  • 37
    • 84904883591 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replication
    • Brulois K, Toth Z, Wong LY, Feng P, Gao SJ, Ensser A, Jung JU. 2014. Kaposi's sarcoma-associated herpesvirus K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replication. J Virol 88:9335-9349. http://dx.doi.org/10.1128/JVI.00873-14.
    • (2014) J Virol , vol.88 , pp. 9335-9349
    • Brulois, K.1    Toth, Z.2    Wong, L.Y.3    Feng, P.4    Gao, S.J.5    Ensser, A.6    Jung, J.U.7
  • 38
    • 33750470785 scopus 로고    scopus 로고
    • Quantitative membrane proteomics reveals new cellular targets of viral immune modulators
    • Bartee E, McCormack A, Fruh K. 2006. Quantitative membrane proteomics reveals new cellular targets of viral immune modulators. PLoS Pathog 2:e107. http://dx.doi.org/10.1371/journal.ppat.0020107.
    • (2006) PLoS Pathog , vol.2
    • Bartee, E.1    McCormack, A.2    Fruh, K.3
  • 39
    • 84888267145 scopus 로고    scopus 로고
    • Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases
    • Timms RT, Duncan LM, Tchasovnikarova IA, Antrobus R, Smith DL, Dougan G, Weekes MP, Lehner PJ. 2013. Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases. PLoS Pathog 9:e1003772. http://dx.doi.org/10.1371/journal.ppat.1003772.
    • (2013) PLoS Pathog , vol.9
    • Timms, R.T.1    Duncan, L.M.2    Tchasovnikarova, I.A.3    Antrobus, R.4    Smith, D.L.5    Dougan, G.6    Weekes, M.P.7    Lehner, P.J.8
  • 40
    • 18244402636 scopus 로고    scopus 로고
    • Regulation of CD1d expression and function by a herpesvirus infection
    • Sanchez DJ, Gumperz JE, Ganem D. 2005. Regulation of CD1d expression and function by a herpesvirus infection. J Clin Invest 115:1369-1378. http://dx.doi.org/10.1172/JCI200524041.
    • (2005) J Clin Invest , vol.115 , pp. 1369-1378
    • Sanchez, D.J.1    Gumperz, J.E.2    Ganem, D.3
  • 41
    • 40349108461 scopus 로고    scopus 로고
    • Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity
    • Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ. 2008. Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity. Proc Natl Acad Sci U S A 105:1656-1661. http://dx.doi.org/10.1073/pnas.0707883105.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 1656-1661
    • Thomas, M.1    Boname, J.M.2    Field, S.3    Nejentsev, S.4    Salio, M.5    Cerundolo, V.6    Wills, M.7    Lehner, P.J.8
  • 42
    • 33847238748 scopus 로고    scopus 로고
    • Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5
    • Li Q, Means R, Lang S, Jung JU. 2007. Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5. J Virol 81:2117-2127. http://dx.doi.org/10.1128/JVI.01961-06.
    • (2007) J Virol , vol.81 , pp. 2117-2127
    • Li, Q.1    Means, R.2    Lang, S.3    Jung, J.U.4
  • 43
    • 0346373729 scopus 로고    scopus 로고
    • Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins
    • Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K. 2004. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J Virol 78: 1109-1120. http://dx.doi.org/10.1128/JVI.78.3.1109-1120.2004.
    • (2004) J Virol , vol.78 , pp. 1109-1120
    • Bartee, E.1    Mansouri, M.2    Hovey Nerenberg, B.T.3    Gouveia, K.4    Fruh, K.5
  • 46
    • 33845618137 scopus 로고    scopus 로고
    • MARCH-IX mediates ubiquitination and downregulation of ICAM-1
    • Hoer S, Smith L, Lehner PJ. 2007. MARCH-IX mediates ubiquitination and downregulation of ICAM-1. FEBS Lett 581:45-51. http://dx.doi.org/10.1016/j.febslet.2006.11.075.
    • (2007) FEBS Lett , vol.581 , pp. 45-51
    • Hoer, S.1    Smith, L.2    Lehner, P.J.3
  • 47
    • 67349172917 scopus 로고    scopus 로고
    • The trafficking and regulation of membrane receptors by the RING-CH ubiquitin E3 ligases
    • Nathan JA, Lehner PJ. 2009. The trafficking and regulation of membrane receptors by the RING-CH ubiquitin E3 ligases. Exp Cell Res 315:1593-1600. http://dx.doi.org/10.1016/j.yexcr.2008.10.026.
    • (2009) Exp Cell Res , vol.315 , pp. 1593-1600
    • Nathan, J.A.1    Lehner, P.J.2
  • 48
    • 22544482352 scopus 로고    scopus 로고
    • Reduced prevalence of Epstein-Barr virus-related lymphocryptovirus infection in sera from a new world primate
    • Fogg MH, Carville A, Cameron J, Quink C, Wang F. 2005. Reduced prevalence of Epstein-Barr virus-related lymphocryptovirus infection in sera from a new world primate. J Virol 79:10069-10072. http://dx.doi.org/10.1128/JVI.79.15.10069-10072.2005.
    • (2005) J Virol , vol.79 , pp. 10069-10072
    • Fogg, M.H.1    Carville, A.2    Cameron, J.3    Quink, C.4    Wang, F.5
  • 49
    • 84880299051 scopus 로고    scopus 로고
    • Nonhuman primate models for Epstein-Barr virus infection
    • Wang F. 2013. Nonhuman primate models for Epstein-Barr virus infection. Curr Opin Virol 3:233-237. http://dx.doi.org/10.1016/j.coviro.2013.03.003.
    • (2013) Curr Opin Virol , vol.3 , pp. 233-237
    • Wang, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.