Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis

European Journal of Immunology

Volumn 46, Issue 1, 2016, Pages 104-113

  Mundt, Sarah ^a   Engelhardt, Britta ^b   Kirk, Christopher J ^c,e   Groettrup, Marcus ^a,d   Basler, Michael ^a,d  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

^c ONYX PHARMACEUTICALS   (United States)

^d UNIVERSITY OF KONSTANZ   (Switzerland)

^e Kezar Life Sciences   (United States)

Author keywords

CNS inflammation; Cytotoxic T cells; Immunoproteasome; LMP7; Lymphocytic choriomeningitis virus

Indexed keywords

GAMMA INTERFERON; ONX 0914; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN LMP7; UNCLASSIFIED DRUG; LMP7 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARENAVIRUS INFECTION; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DISEASE SEVERITY; IMMUNOPATHOLOGY; INFLAMMATORY INFILTRATE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICROGLIA; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; VIRAL CLEARANCE; VIRUS MENINGITIS; VIRUS PATHOGENESIS; ANIMAL; C57BL MOUSE; DISEASE MODEL; FLOW CYTOMETRY; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS; PATHOLOGY;

ANIMALS; ANTIGEN PRESENTATION; ARENAVIRIDAE INFECTIONS; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEASOME ENDOPEPTIDASE COMPLEX; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84953835791     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201545578     Document Type: Article

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