Diversity in Clinical and Biomedical Research: A Promise Yet to Be Fulfilled

PLoS Medicine

Volumn 12, Issue 12, 2015, Pages

  Oh, Sam S ^a   Galanter, Joshua ^a,b   Thakur, Neeta ^a   Pino Yanes, Maria ^a,c,d   Barcelo, Nicolas E ^a   White, Marquitta J ^a   de Bruin, Danielle M ^a   Greenblatt, Ruth M ^a,b   Bibbins Domingo, Kirsten ^a,e   Wu, Alan H B ^a   Borrell, Luisa N ^f   Gunter, Chris ^g,h   Powe, Neil R ^a,e   Burchard, Esteban G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^e SAN FRANCISCO GENERAL HOSPITAL   (United States)

^f CITY UNIVERSITY OF NEW YORK   (United States)

^g CHILDREN'S HEALTHCARE OF ATLANTA   (United States)

^h EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMMUNITY ASSESSMENT; CULTURAL ANTHROPOLOGY; ETHNICITY; FOOD AND DRUG ADMINISTRATION; FUNDING; GOVERNMENT REGULATION; HEALTH CARE DISPARITY; HUMAN; MEDICAL RESEARCH; NATIONAL HEALTH ORGANIZATION; PUBLIC HEALTH SERVICE; SCIENTIST; SOCIOECONOMICS; UNITED STATES; CULTURAL DIVERSITY; ETHICS; LEGISLATION AND JURISPRUDENCE; SOCIAL JUSTICE; STATISTICS AND NUMERICAL DATA;

BIOMEDICAL RESEARCH; CULTURAL DIVERSITY; HUMANS; SOCIAL JUSTICE; UNITED STATES;

EID: 84953775562     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1001918     Document Type: Article

References (55)

1. US CongressNational Institutes of Health Revitalization Act of 1993: Act to Amend the Public Health Service Act to Revise and Extend the Programs of the National Institutes of Health, and for Other Purposes. Public Law Washington, DC; 1993 pp. 103–143.
2. Canto JG, Goldberg RJ, Hand MM, Bonow RO, Sopko G, Pepine CJ, et al. Symptom presentation of women with acute coronary syndromes: myth vs reality. Archives of internal medicine. 2007;167: 2405–2413. doi: 10.1001/archinte.167.22.2405 18071161
3. Gandhi M, Aweeka F, Greenblatt RM, Blaschke TF, Sex differences in pharmacokinetics and pharmacodynamics. Annu Rev Pharmacol Toxicol. 2004;44: 499–523. doi: 10.1146/annurev.pharmtox.44.101802.121453 14744256
4. Rathore SS, Wang Y, Krumholz HM, Sex-based differences in the effect of digoxin for the treatment of heart failure. N Engl J Med. 2002;347: 1403–1411. doi: 10.1056/NEJMoa021266 12409542
5. Clayton JA, Collins FS, Policy: NIH to balance sex in cell and animal studies. Nature. 2014;509: 282–283. 24834516
6. Remarks by the President in State of the Union Address | January 20, 2015. 2015. https://www.whitehouse.gov/the-press-office/2015/01/20/remarks-president-state-union-address-january-20-2015
7. Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, et al. The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med. 2003;348: 1170–1175. doi: 10.1056/NEJMsb025007 12646676
8. Kaufman JS, Cooper RS, McGee DL, Socioeconomic status and health in blacks and whites: the problem of residual confounding and the resiliency of race. Epidemiology. 1997;8: 621–628. 9345660
9. Wu AH, White MJ, Oh SS, Burchard E, The Hawaii clopidogrel lawsuit: the possible effect on clinical laboratory testing. Per Med. 2015;12: 179–181. doi: 10.2217/pme.15.4
10. Mega JL, Simon T, Collet J-P, Anderson JL, Antman EM, Bliden K, et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA: The Journal of the American Medical Association. 2010;304: 1821–1830. doi: 10.1001/jama.2010.1543 20978260
11. Fejerman L, Ahmadiyeh N, Hu D, Huntsman S, Beckman KB, Caswell JL, et al. Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25. Nat Commun. 2014;5: 5260. doi: 10.1038/ncomms6260 25327703
12. Carson P, Ziesche S, Johnson G, Cohn JN, Racial differences in response to therapy for heart failure: analysis of the vasodilator-heart failure trials. Vasodilator-Heart Failure Trial Study Group. J Card Fail. 1999;5: 178–187. 10496190
13. Ranjit N, Siefert K, Padmanabhan V, Bisphenol-A and disparities in birth outcomes: a review and directions for future research. J Perinatol. 2010;30: 2–9. doi: 10.1038/jp.2009.90 19587689
14. Chung W-H, Hung S-I, Hong H-S, Hsih M-S, Yang L-C, Ho H-C, et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature. 2004;428: 486–486. doi: 10.1038/428486a 15057820
15. Genovese G, Friedman DJ, Ross MD, Lecordier L, Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010 Aug 13;329(5993):841–5. doi: 10.1126/science.1193032 20647424
16. Gandhi M, Greenblatt RM, Bacchetti P, Jin C, Huang Y, Anastos K, et al. A single-nucleotide polymorphism in CYP2B6 leads to >3-fold increases in efavirenz concentrations in plasma and hair among HIV-infected women. The Journal of infectious diseases. 2012;206: 1453–1461. doi: 10.1093/infdis/jis508 22927450
17. Frasco MA, Mack WJ, Van Den Berg D, Aouizerat BE, Anastos K, Cohen M, et al. Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine. AIDS. 2012;26: 2097–2106. doi: 10.1097/QAD.0b013e3283593602 22951632
18. Bhopal RS, Migration, Ethnicity, Race, and Health in Multicultural Societies. 2nd ed. Oxford University Press; 2014.
19. Institute of Medicine (US)Thomson GE, Mitchell F, Williams MB, Committee on the Review and Assessment of the NIH’s Strategic Research Plan and Budget to Reduce and Ultimately Eliminate Health Disparities. Examining the Health Disparities Research Plan of the National Institutes of Health: Unfinished Business. Washington (DC): National Academies Press (US); 2006.
20. Chen MS, Lara PN, Dang JHT, Paterniti DA, Kelly K, Twenty years post-NIH Revitalization Act: enhancing minority participation in clinical trials (EMPaCT): laying the groundwork for improving minority clinical trial accrual: renewing the case for enhancing minority participation in cancer clinical trials. Cancer. 2014;120 Suppl 7: 1091–1096. doi: 10.1002/cncr.28575 24643646
21. Burchard EG, Oh SS, Foreman MG, Celedón JC, Moving toward True Inclusion of Racial/Ethnic Minorities in Federally Funded Studies. A Key Step for Achieving Respiratory Health Equality in the United States. Am J Respir Crit Care Med. 2015;191: 514–521. doi: 10.1164/rccm.201410-1944PP 25584658
22. American Cancer Society. Cancer Facts & Figures 2014. Atlanta: American Cancer Society; 2014.
23. Murthy VH, Krumholz HM, Gross CP, Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA: The Journal of the American Medical Association. 2004;291: 2720–2726. doi: 10.1001/jama.291.22.2720 15187053
24. Chow EA, Foster H, Gonzalez V, McIver L, The Disparate Impact of Diabetes on Racial/Ethnic Minority Populations. Clinical Diabetes. 2012;30: 130–133. doi: 10.2337/diaclin.30.3.130
25. Sardar MR, Badri M, Prince CT, Seltzer J, Kowey PR, Underrepresentation of women, elderly patients, and racial minorities in the randomized trials used for cardiovascular guidelines. JAMA Intern Med. American Medical Association; 2014;174: 1868–1870. doi: 10.1001/jamainternmed.2014.4758 25264856
26. LaVeist TA, Gaskin D, Richard P, Estimating the economic burden of racial health inequalities in the United States. Int J Health Serv. 2011;41: 231–238. doi: 10.2190/HS.41.2.c 21563622
27. National Prevention CouncilNational Prevention Strategy. Washington, DC: US Department of Health and Human Services, Office of the Surgeon General; 2011.
28. Wendler D, Kington R, Madans J, Van Wye G, Christ-Schmidt H, Pratt LA, et al. Are racial and ethnic minorities less willing to participate in health research? PLoS Med. 2006;3: e19. doi: 10.1371/journal.pmed.0030019 16318411
29. Powe NR, Gary TL, Beech BM, Goodman M, Clinical Trials. In: Race & Research: Perspectives on Minority Participation in Health Studies. Washington, DC: American Public Health Association Press; 2004. pp. 61–78.
30. Durant RW, Wenzel JA, Scarinci IC, Paterniti DA, Fouad MN, Hurd TC, et al. Perspectives on barriers and facilitators to minority recruitment for clinical trials among cancer center leaders, investigators, research staff, and referring clinicians: enhancing minority participation in clinical trials (EMPaCT). Cancer. 2014;120 Suppl 7: 1097–1105. doi: 10.1002/cncr.28574 24643647
31. George S, Duran N, Norris K, A systematic review of barriers and facilitators to minority research participation among African Americans, Latinos, Asian Americans, and Pacific Islanders. Am J Public Health. 2014;104: e16–31. doi: 10.2105/AJPH.2013.301706 24328648
32. Sharrocks K, Spicer J, Camidge DR, Papa S, The impact of socioeconomic status on access to cancer clinical trials. Br J Cancer. 2014;111: 1684–1687. doi: 10.1038/bjc.2014.108 25093493
33. Maxwell AE, Bastani R, Vida P, Warda US, Strategies to recruit and retain older Filipino-American immigrants for a cancer screening study. J Community Health. 2005;30: 167–179. doi: 10.1007/s10900-004-1956-0 15847243
34. Johnson VA, Edwards KA, Sherman SL, Stephens LD, Williams W, Adair A, et al. Decisions to participate in fragile X and other genomics-related research: Native American and African American voices. J Cult Divers. 2009;16: 127–135. 19824292
35. Association of American Medical Colleges. The Diversity Research Forum: The Importance and Benefits of Diverse Faculty in Academic Medicine: Implications for Recruitment, Retention, and Promotion. Washington, DC; 2009.
36. National Science Foundation. Doctorate recipients from US colleges and universities [Internet]. [cited 11 Sep 2015]. http://www.nsf.gov/statistics/sed/2013/data/tab24.pdf
37. Rockey S. Diversity—Looking at the Numbers [Internet]. [cited 24 Sep 2014]. http://nexus.od.nih.gov/all/2012/07/20/diversity-looking-at-the-numbers
38. Rockey S. New NIH Study on Diversity [Internet]. [cited 23 Sep 2014]. http://nexus.od.nih.gov/all/2011/08/18/new-nih-study-on-diversity/
39. Ginther DK, Schaffer WT, Schnell J, Masimore B, Liu F, Haak LL, et al. Race, ethnicity, and NIH research awards. Science. 2011;333: 1015–1019. doi: 10.1126/science.1196783 21852498
40. Freedom of Information Act Request. NIH/Office of Extramural Research. 2014.
41. Reardon S, NIH to probe racial disparity in grant awards. Nature. 2014;512: 243–243. doi: 10.1038/512243a 25143096
42. NIH VideoCast—Advisory Committee to the Director—December 2014 (Day 1) [Internet]. [cited 18 Dec 2014]. http://videocast.nih.gov/summary.asp?live=15269&bhcp=1
43. National Research Council, Committee on the Science of Team ScienceCooke NJ, Hilton ML, Enhancing the Effectiveness of Team Science. Washington (DC): National Academies Press (US); 2015.
44. Freeman RB, Huang W, Collaboration: Strength in diversity. Nature. 2014;513: 305. doi: 10.1038/513305a 25230634
45. Tabak LA, Collins FS, Weaving a richer tapestry in biomedical science. Science. 2011;333: 940–941. doi: 10.1126/science.1211704 21852476
46. Request for Information: NIH Precision Medicine Cohort. 2015. http://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-096.html
47. Collins FS, Varmus H, A new initiative on precision medicine. N Engl J Med. 2015;372: 793–795. doi: 10.1056/NEJMp1500523 25635347
48. NIH Precision Medicine Initiative [Internet]. [cited 1 Sep 2015]. http://www.nih.gov/precisionmedicine/events.htm
49. ACD Precision Medicine Initiative Working Group Public Workshop. Participant Engagement and Health Equity Workshop Summary [Internet]. [cited 1 Sep 2015]. http://www.nih.gov/precisionmedicine/2015-07-01-workshop-summary.pdf
50. PA-15-034: Administrative Supplements for Research on Sex/Gender Differences (Admin Supp) [Internet]. [cited 30 Dec 2014]. http://grants.nih.gov/grants/guide/pa-files/PA-15-034.html
51. Rockey S. New Efforts to Maximize Fairness in NIH Peer Review [Internet]. [cited 23 Sep 2014]. http://nexus.od.nih.gov/all/2014/05/29/new-efforts-to-maximize-fairness-in-nih-peer-review/
52. CSR Announces Winners of its America COMPETES Challenges to Maximize Fairness in NIH Peer Review, [Internet]. [cited 14 Dec 2014]. http://public.csr.nih.gov/Documents/LearnMoreabouttheWinningIdeas.pdf
53. NIH proposes critical initiatives to sustain future of US biomedical research [Internet]. [cited 1 Sep 2015]. http://www.nih.gov/news/health/dec2012/od-07.htm
54. Enhancing the Diversity of the NIH-Funded Workforce [Internet]. [cited 16 Dec 2014]. http://commonfund.nih.gov/diversity/Initiatives
55. King G, Institutional racism and the medical/health complex: a conceptual analysis. Ethn Dis. 1996 Winter-Spring;6(1–2):30–46.