Genome-wide mutational signature of the chemotherapeutic agent mitomycin C in Caenorhabditis elegans

G3: Genes, Genomes, Genetics

Volumn 6, Issue 1, 2016, Pages 133-140

  Tam, Annie S ^a,b   Chu, Jeffrey S C ^c   Rose, Ann M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c Wuhan Frasergen Bioinformatics Co Ltd   (China)

Author keywords

C. elegans; Mitomycin C; Model organism; Mutation spectrum; Whole genome sequencing

Indexed keywords

GENOMIC DNA; MITOMYCIN; ANTINEOPLASTIC AGENT; MUTAGENIC AGENT;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DNA CROSS LINKING; DNA DAMAGE; DNA END JOINING REPAIR; FUNGAL STRAIN; FUNGUS MUTATION; GENE DELETION; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RECOMBINATION; GENOME ANALYSIS; INDEL MUTATION; MUTAGENESIS; MUTATION RATE; NONHUMAN; ANIMAL; BIOLOGY; CHROMOSOMAL MAPPING; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GENOME; GENOMICS; GENOTYPE; HIGH THROUGHPUT SEQUENCING; LETHAL GENE; MUTATION; PROCEDURES; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; ANTINEOPLASTIC AGENTS; CAENORHABDITIS ELEGANS; CHROMOSOME MAPPING; COMPUTATIONAL BIOLOGY; DNA DAMAGE; GENES, LETHAL; GENOME; GENOMICS; GENOTYPE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; MITOMYCIN; MUTAGENESIS, INSERTIONAL; MUTAGENS; MUTATION; MUTATION RATE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE DELETION;

EID: 84953744423     PISSN: None     EISSN: 21601836     Source Type: Journal    
DOI: 10.1534/g3.115.021915     Document Type: Article

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