Mutants of collagen-specific molecular chaperone Hsp47 causing osteogenesis imperfecta are structurally unstable with weak binding affinity to collagen

Biochemical and Biophysical Research Communications

Volumn 469, Issue 3, 2016, Pages 437-442

  Ito, Shinya ^a,b   Nagata, Kazuhiro ^b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO SANGYO UNIVERSITY   (Japan)

Author keywords

Chemical chaperone; Collagen; ER stress; Molecular chaperone Hsp47; Osteogenesis imperfecta

Indexed keywords

CHAPERONE; COLLAGEN; HEAT SHOCK PROTEIN 47; PROCOLLAGEN; COLLAGEN TYPE 1; PROTEIN BINDING; SERPINH1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; EXPRESSION VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OSTEOGENESIS IMPERFECTA; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN STRUCTURE; WESTERN BLOTTING; WILD TYPE; ANIMAL; BINDING SITE; GENETICS; METABOLISM; MUTATION; PATHOPHYSIOLOGY;

ANIMALS; BINDING SITES; COLLAGEN TYPE I; HSP47 HEAT-SHOCK PROTEINS; HUMANS; MICE; MUTATION; OSTEOGENESIS IMPERFECTA; PROTEIN BINDING;

EID: 84953438730     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.12.028     Document Type: Article

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