Chikusetsu Saponin IVa Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice via Adiponectin-Mediated AMPK/GSK-3β Pathway In Vivo and In Vitro

Molecular Neurobiology

Volumn 53, Issue 1, 2016, Pages 728-743

  Duan, Jialin ^a   Yin, Ying ^a   Cui, Jia ^a   Yan, Jiajia ^a   Zhu, Yanrong ^a   Guan, Yue ^a   Wei, Guo ^a   Weng, Yan ^a   Wu, Xiaoxiao ^a   Guo, Chao ^a   Wang, Yanhua ^a   Xi, Miaomiao ^a   Wen, Aidong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Adiponectin; AdipoRs; AMPK; Chikusetsu saponin IVa; Diabetes; GSK 3

Indexed keywords

ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; ADENYLATE KINASE; ADIPONECTIN; CASPASE 3; CHIKUSETSU SAPONIN; GLYCOGEN SYNTHASE KINASE 3BETA; MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE; ROSIGLITAZONE; SMALL INTERFERING RNA; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CHIKUSETSU SAPONIN IVA; GLYCOGEN SYNTHASE KINASE 3; GSK3B PROTEIN, MOUSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; OLEANOLIC ACID; SAPONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PC12 CELL LINE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TREATMENT DURATION; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DIABETES MELLITUS, EXPERIMENTAL; DOSE RESPONSE; DRUG EFFECTS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ADIPONECTIN; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BRAIN ISCHEMIA; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLEANOLIC ACID; REPERFUSION INJURY; SAPONINS; SIGNAL TRANSDUCTION;

EID: 84953367923     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-9033-x     Document Type: Article

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