Lipid profile and platelet aggregation of ethanolic seed extract of avocado (Persea Americana Mill.) in hyperlipidemic male wistar rat

Asian Journal of Pharmaceutical and Clinical Research

Volumn 9, Issue 1, 2016, Pages 108-112

  Soemardji, Andreanus Andaja ^a   Umar, Matuar Hi ^a   Fidrianny, Irda ^b  

^a Pharmacology Clinical Pharmacy Research Group   (Indonesia)

^b BANDUNG INSTITUTE OF TECHNOLOGY   (Indonesia)

Author keywords

Avocado; Cholesterol; Persea americana Mill.; Platelet aggregation; Seed

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ANTICOAGULANT AGENT; ANTILIPEMIC AGENT; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LIPID; LOW DENSITY LIPOPROTEIN; PERSEA AMERICANA EXTRACT; PLANT EXTRACT; SIMVASTATIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; AVOCADO; BLEEDING TIME; BLOOD CLOTTING TIME; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG MECHANISM; HYPERLIPIDEMIA; LIPID ANALYSIS; MALE; NONHUMAN; PLANT SEED; RAT; THROMBOCYTE AGGREGATION;

EID: 84953328852     PISSN: 09742441     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Jahnavi N, Naidu PP, Rao K, Karunasree CP. Antihyperlipidemic effect of Asparagus gonnoclados baker against cholesterol diet induced hyperlipidemia in rats. Asian J Pharm Clin Res 2014;7(2):212-5.
2. van der Stoep M, Korporaal SJ, Van Eck M. High-density lipoprotein as a modulator of platelet and coagulation responses. Cardiovasc Res 2014;103(3):362-71.
3. nded. Amsterdam: Saunders Elsevier; 2006. p. 166-76.
4. Asaolu MF, Asaolu SS, Oyeyemi AO, Aluko BT. Hypolipemic effects of methanolic extract of Persea americana seeds in hypercholesterolemic rats. J Med Sci 2010;1(14):126-8.
5. Sodipo OA, Akiniyi JA. Studies on certain characteristics of extracts from bark of Pausinystalia macroceras (K. schum). Pierre Exbeille. Glob J Pure Appl Sci 2000;6:83-7.
6. Arukwe U, Amadi BA, Duru MK, Agomuo EN, Adindu EA, Odika PC, et al. Chemical compositon of Persea americana leaf, fruit and seed. Int J Res Rev Appl Sci 2012;11(2):346-9.
7. Duke J. Handbook of Biological Active Phytochemicals and their Activities. Boca Raton, FL: CRC Press; 1992. p. 99-131.
8. Pahua-Ramos ME, Ortiz-Moreno A, Chamorro-Cevallos G, Hernández-Navarro MD, Garduño-Siciliano L, Necoechea-Mondragón H, et al. Hypolipidemic effect of avocado (Persea americana Mill) seed in a hypercholesterolemic mouse model. Plant Foods Hum Nutr 2012;67(1):10-6.
9. Permatasari A. The effect of simvastatin, aspirin, their combination and bungur ethanolic extract (Lagerstroemia speciose (L.) Pers.) in initiation step of atheroma plaque. School of Pharmacy-Bandung Institute of Technology; 2014. p. 26-7.
10. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18(6):499-502.
11. Venkataraman S, Meera R, Ramchandran V, Devi P, Aruna A, Parameswari SP, et al. Antioxidant and anticoagulant activity of novel n-substituted 4 methyl 5, 7 dihydroxylcoumarin and its ester derivatives. Int J Pharm Rev Res 2004;4(1):25-32.
12. Sukandar EY, Sigit JI, Fitriyani N. Antiplatelet aggregation of garlic (Allium sativumL.) water extract, turmeric (Curcuma domestica Val.) ethanolic extract and its combination to Swiss Webster male mice. Indones J Pharm 2008;19(1):1-11.
13. rded. New York: Springer-Verlag Berlin Heidelberg; 2008.
14. Yang W, Jun WD, Zhang R, Deng Q, Ding H, Tian Y, et al. Effects of propylthiouracil-induced hypothyroidism on nonalcoholic fatty liver disease in rats fed a high-fat and high-cholesterol diet. Pak Vet J 2014;35(1):1-6.
15. Barth CA. Regulation and interactions of cholesterol, bile salt, and lipoprotein synthesis in liver. Klin Wochenschr 1984;163-70.
16. Radcliffe JD, Liebsch KS. Dietary induction of hypercholesterolemia and atherosclerosis in Japanese quail of strain SEA. J Nutr 1985;115:154-61.
17. Nwanjo HU. Efficacy of aqueous leaf extracts of Vernonia amygdalinaon plasma lipoprotein and oxidative status in diabetic rats models. Niger J Physiol Sci 2005;20:39-42.
18. Gerd A, Gotto AM. HDL cholesterol and protective factors in atherosclerosis. Circulation 2004;109:8-14.
19. Villa J, Pratley RE. Ezetimibe/simvastatin or atorvastatin for the treatment of hypercholesterolemia in patients with the metabolic syndrome: The VYMET study. Curr Diab Rep 2010;10(3):173-5.
20. McCormack T, Harvey P, Gaunt R, Allgar V, Chipperfield R, Robinson P. Incremental cholesterol reduction with ezetimibe/simvastatin, atorvastatin and rosuvastatin in UK General Practice (IN-PRACTICE): Randomised controlled trial of achievement of Joint British Societies (JBS-2) cholesterol targets. Int J Clin Pract 2010;64(8):1052-61.
21. Goldberg IJ. Diabetic dyslipidemia: Causes and consequences. J Clin Endocrinol Metab 2001;86:965-71.
22. Prociuk MA, Edel AL, Richard MN, Gavel NT, Ander BP, Dupasquier CM, et al. Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet. Can J Physiol Pharmacol 2008;86:153-9.