Preclinical bioassay of a polypropylene mesh for hernia repair pretreated with antibacterial solutions of chlorhexidine and allicin: An in vivo study

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  Pérez Köhler, Bárbara ^a,c   García Moreno, Francisca ^a,c   Brune, Thierry ^b   Pascual, Gemma ^a,c   Bellón, Juan Manuel ^a,c  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b MEDTRONIC INC   (United States)

^c BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALLICIN; CHLORHEXIDINE; POLYPROPYLENE; ANTIINFECTIVE AGENT; BIOMATERIAL; SULFINIC ACID DERIVATIVE;

ABDOMINAL WALL HERNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BACTERIUM ADHERENCE; BIOASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HERNIOPLASTY; HISTOPATHOLOGY; IN VIVO STUDY; MACROPHAGE; MALE; NEW ZEALAND WHITE (RABBIT); NONHUMAN; PROSTHESIS INFECTION; RABBIT MODEL; SCANNING ELECTRON MICROSCOPY; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; SURGICAL MESH; ULTRASOUND; ANIMAL; HERNIORRHAPHY; PROCEDURES; RABBIT; STAPHYLOCOCCAL INFECTIONS; TREATMENT OUTCOME;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOCOMPATIBLE MATERIALS; BIOLOGICAL ASSAY; CHLORHEXIDINE; HERNIORRHAPHY; RABBITS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; SULFINIC ACIDS; SURGICAL MESH; TREATMENT OUTCOME;

EID: 84953293936     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0142768     Document Type: Article

References (49)

1. Stoikes N, Voeller GR. New developments in hernia repair: A 2013 update. Surg Technol Int. 2013; 23: 107-111.
2. Luijendijk RW, Hop WC, van den Tol MP, de Lange DC, Braaksma MM, IJzermans JN, et al. A comparison of suture repair with mesh repair for incisional hernia. N Engl J Med. 2000; 343: 392-398.
3. Burger JW, Luijendijk RW, Hop WC, Halm JA, Verdaasdonk EG, Jeekel J. Long-Term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia. Ann Surg. 2004; 240: 578-583.
4. Falagas ME, Kasiakou SK. Mesh-related infections after hernia repair surgery. Clin Microbiol Infect. 2005; 11: 3-8.
5. Carbonell AM, Matthews BD, Dréau D, Foster M, Austin CE, Kercher KW, et al. The susceptibility of prosthetic biomaterials to infection. Surg Endosc. 2005; 19: 430-435.
6. Cobb WS, Carbonell AM, Kalbaugh CL, Jones Y, Lokey JS. Infection risk of open placement of intraperitoneal composite mesh. Am Surg. 2009; 75: 762-768.
7. Gristina AG, Naylor P, Myrvik QN. Infections from biomaterials and implants: A race for the surface. Med Prog Technol. 1988; 14: 205-224.
8. Engelsman AF, van der Mei HC, Ploeg RJ, Busscher HJ. The phenomenon of infection with abdominal wall reconstruction. Biomaterials. 2007; 28: 2314-2327.
9. Deysine M. Pathophysiology, prevention, and management of prosthetic infections in hernia surgery. Surg Clin North Am. 1998; 78: 1105-1115.
10. An YH, Friedman RJ. Laboratory methods for studies of bacterial adhesion. J Microbiol Methods. 1997; 30: 141-152.
11. Katsikogianni M, Missirlis YF. Concise review of mechanisms of bacterial adhesion to biomaterials and of techniques used in estimating bacteria-material interactions. Eur Cell Mater. 2004; 8: 37-57.
12. Aydinuraz K, Aʇalar C, Aʇalar F, Ceken S, Duruyörek N, Vural T. In vitro S. epidermidis and S. aureus adherence to composite and lightweight polypropylene grafts. J Surg Res. 2009; 157: e79-e86. doi: 10.1016/j.jss.2009.04.008
13. Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev. 2002; 15: 167-193.
14. Costerton JW, Montanaro L, Arciola CR. Biofilm in implant infections: its production and regulation. Int J Artif Organs. 2005; 28: 1062-1068.
15. Lindsay D, von Holy A. Bacterial biofilms within the clinical setting: what healthcare professionals should know. J Hosp Infect. 2006; 64: 313-325.
16. Sanders DL, Kingsnorth AN, Lambie J, Bond P, Moate R, Steer JA. An experimental study exploring the relationship between the size of bacterial inoculum and bacterial adherence to prosthetic mesh. Surg Endosc. 2013; 27: 978-985. doi: 10.1007/s00464-012-2545-4
17. Sanabria A, Domínguez LC, Valdivieso E, Gómez G. Prophylactic antibiotics for mesh inguinal hernioplasty: A meta-Analysis. Ann Surg. 2007; 245: 392-396.
18. Wiegering A, Sinha B, Spor L, Klinge U, Steger U, Germer CT, et al. Gentamicin for prevention of intraoperative mesh contamination: demonstration of high bactericide effect (in vitro) and low systemic bioavailability (in vivo). Hernia. 2014; 18: 691-700. doi: 10.1007/s10029-014-1293-x
19. Sánchez-Manuel FJ, Lozano-García J, Seco-Gil JL. Antibiotic prophylaxis for hernia repair. Cochrane Database Syst Rev. 2012; 2:CD003769. doi: 10.1002/14651858.CD003769.pub4
20. Köckerling F, Bittner R, Jacob D, Schug-Pass C, Laurenz C, Adolf D, et al. Do we need antibiotic prophylaxis in endoscopic inguinal hernia repair? Results of the Herniamed Registry. Surg Endosc. 2015; 25786905.
21. Binnebösel M, von Trotha KT, Jansen PL, Conze J, Neumann UP, Junge K. Biocompatibility of prosthetic meshes in abdominal surgery. Semin Immunopathol. 2011; 33: 235-243. doi: 10.1007/s00281-010-0237-5
22. Guillaume O, Garric X, Lavigne JP, Van Den Berghe H, Coudane J. Multilayer, degradable coating as a carrier for the sustained release of antibiotics: preparation and antimicrobial efficacy in vitro. J Control Release. 2012; 162: 492-501. doi: 10.1016/j.jconrel.2012.08.003
23. Harth KC, Rosen MJ, Thatiparti TR, Jacobs MR, Halaweish I, Bajaksouzian S, et al. Antibiotic-releasing mesh coating to reduce prosthetic sepsis: An in vivo study. J Surg Res. 2010; 163: 337-343. doi: 10. 1016/j.jss.2010.03.065
24. Tambe SM, Sampath L, Modak SM. In vitro evaluation of the risk of developing bacterial resistance to antiseptics and antibiotics used in medical devices. J Antimicrob Chemother 2001; 47: 589-598.
25. Yurko Y, McDeavitt K, Kumar RS, Martin T, Prabhu A, Lincourt AE, et al. Antibacterial mesh: A novel technique involving naturally occurring cellular proteins. Surg Innov. 2012; 19: 20-26. doi: 10.1177/1553350611410716
26. Fernández-Gutiérrez M, Olivares E, Pascual G, Bellón JM, San Román J. Low-density polypropylene meshes coated with resorbable and biocompatible hydrophilic polymers as controlled release agents of antibiotics. Acta Biomater. 2013; 9: 6006-6018. doi: 10.1016/j.actbio.2012.12.012
27. Agarwal A, Nelson TB, Kierski PR, Schurr MJ, Murphy CJ, Czuprynski CJ, et al. Polymeric multilayers that localize the release of chlorhexidine from biologic wound dressings. Biomaterials. 2012; 33: 6783-6792. doi: 10.1016/j.biomaterials.2012.05.068
28. Sistla SC, Prabhu G, Sistla S, Sadasivan J. Minimizing wound contamination in a 'clean' surgery: comparison of chlorhexidine-ethanol and povidone-iodine. Chemotherapy. 2010; 56: 261-267. doi: 10. 1159/000319901
29. von Eiff C, Jansen B, Kohnen W, Becker K. Infections associated with medical devices: pathogenesis, management and prophylaxis. Drugs. 2005; 65: 179-214.
30. Ankri S, Mirelman D. Antimicrobial properties of allicin from garlic. Microbes Infect. 1999; 1: 125-129.
31. Cutler RR, Wilson P. Antibacterial activity of a new, stable, aqueous extract of allicin against methicillinresistant Staphylococcus aureus. Br J Biomed Sci. 2004; 61: 71-74.
32. Cruz-Villalón G, Pérez-Giraldo C. Effect of allicin on the production of polysaccharide intercellular adhesin in Staphylococcus epidermidis. J Appl Microbiol. 2011; 110: 723-728. doi: 10.1111/j.1365-2672. 2010.04929.x
33. Pérez-Köhler B, García-Moreno F, Bayon Y, Pascual G, Bellón JM. Inhibition of Staphylococcus aureus adhesion to the surface of a reticular heavyweight polypropylene mesh soaked in a combination of chlorhexidine and allicin: An in vitro study. PLoS One. 2015; 10: e0126711. doi: 10.1371/journal.pone. 0126711
34. Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. PLOS Biol. 2010; 8: e1000412. doi: 10.1371/journal.pbio.1000412
35. Bellón JM. Classification of prosthetic materials used in hernia repair according to their structure and behavior with regard to tissue integration. Rev Hispanoam Hernia. 2014; 2: 49-57.
36. Sanders D, Lambie J, Bond P, Moate R, Steer JA. An in vitro study assessing the effect of mesh morphology and suture fixation on bacterial adherence. Hernia 2013; 17: 779-789. doi: 10.1007/s10029-013-1124-5
37. Bellón JM, García-Carranza A, García-Honduvilla N, Carrera-San Martín A, Buján J. Tissue integration and biomechanical behaviour of contaminated experimental polypropylene and expanded polytetrafluoroethylene implants. Br J Surg. 2004; 91: 489-494.
38. Hodge G, Hodge S, Han P. Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry. 2002; 48: 209-215.
39. Keiss HP, Dirsch VM, Hartung T, Haffner T, Trueman L, Auger J, et al. Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-Activated human blood thereby inhibiting NF-kappaB activity. J Nutr. 2003; 133: 2171-2175.
40. Gordon S, Taylor PR.Monocyte andmacrophage heterogeneity. Nature Rev Immunol. 2005; 5: 953-964.
41. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: Tumor-Associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002; 23: 549-555.
42. Haase H, Hieke N, Plum LM, Gruhlkeb MCH, Slusarenkob AJ, Rink L. Impact of allicin on macrophage activity. Food Chem. 2012; 134: 141-148.
43. Edmiston CE Jr, Bruden B, Rucinski MC, Henen C, Graham MB, Lewis BL. Reducing the risk of surgical site infections: does chlorhexidine gluconate provide a risk reduction benefit? Am J Infect Control. 2013; 41: S49-55. doi: 10.1016/j.ajic.2012.10.030
44. Mann TJ, Orlikowski CE, Gurrin LC, Keil AD. The effect of the biopatch, a chlorhexidine impregnated dressing, on bacterial colonization of epidural catheter exit sites. Anaesth Intensive Care. 2001; 29: 600-603.
45. Giannelli M, Chellini F, Margheri M, Tonelli P, Tani A. Effect of chlorhexidine digluconate on different cell types: A molecular and ultrastructural investigation. Toxicol In Vitro. 2008; 22: 308-317.
46. Zhai H, Pan J, Pang E, Bai B. Lavage with allicin in combination with vancomycin inhibits biofilm formation by Staphylococcus epidermidis in a rabbit model of prosthetic joint infection. PLoS One. 2014; 9: e102760. doi: 10.1371/journal.pone.0102760
47. García-Pumarino R, Pascual G, Rodríguez M, Pérez-Köhler B, Bellón JM. Do collagen meshes offer any benefits over Preclude1 ePTFE implants in contaminated surgical fields? A comparative in vitro and in vivo study. J Biomed Mater Res B Appl Biomater. 2014; 102: 366-375. doi: 10.1002/jbm.b. 33015
48. Harrell AG, Novitsky YW, Kercher KW, FosterM, Burns JM, Kuwada TS, et al. In vitro infectability of prostheticmesh bymethicillin-resistant Staphylococcus aureus. Hernia. 2006; 10: 120-124.
49. Guillaume O, Teuschl AH, Gruber-Blum S, Fortelny RH, Redl H, Petter-Puchner A. Emerging trends in abdominal wall reinforcement: bringing bio-functionality to meshes. Adv Healthc Mater. 2015; 4: 1763-1789. doi: 10.1002/adhm.201500201