메뉴 건너뛰기




Volumn 113, Issue 1, 2016, Pages E61-E70

Limitations of GCTA as a solution to the missing heritability problem

Author keywords

GCTA; GWAS; Heritability; Singular value decomposition; SNP

Indexed keywords

ARTICLE; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIABILITY; GENOME WIDE COMPLEX TRAIT ANALYSIS; GENOTYPE; HERITABILITY; HUMAN; MEASUREMENT ERROR; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; GENOME-WIDE ASSOCIATION STUDY; INFORMATION PROCESSING; PROCEDURES; QUANTITATIVE TRAIT; STATISTICAL ANALYSIS; STATISTICS AND NUMERICAL DATA;

EID: 84953286476     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1520109113     Document Type: Article
Times cited : (74)

References (43)
  • 1
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio TA, et al. (2009) Finding the missing heritability of complex diseases. Nature 461(7265):747-753.
    • (2009) Nature , vol.461 , Issue.7265 , pp. 747-753
    • Manolio, T.A.1
  • 2
    • 55549147191 scopus 로고    scopus 로고
    • Personal genomes: The case of the missing heritability
    • Maher B (2008) Personal genomes: The case of the missing heritability. Nature 456(7218):18-21.
    • (2008) Nature , vol.456 , Issue.7218 , pp. 18-21
    • Maher, B.1
  • 3
    • 42649139571 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies 20 loci that influence adult height
    • Weedon MN, et al.; Diabetes Genetics Initiative; Wellcome Trust Case Control Consortium; Cambridge GEM Consortium (2008) Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet 40(5):575-583.
    • (2008) Nat Genet , vol.40 , Issue.5 , pp. 575-583
    • Weedon, M.N.1
  • 4
    • 77954140531 scopus 로고    scopus 로고
    • Common SNPs explain a large proportion of the heritability for human height
    • Yang J, et al. (2010) Common SNPs explain a large proportion of the heritability for human height. Nat Genet 42(7):565-569.
    • (2010) Nat Genet , vol.42 , Issue.7 , pp. 565-569
    • Yang, J.1
  • 5
    • 84862777863 scopus 로고    scopus 로고
    • Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
    • Lee SH, et al.; Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ); International Schizophrenia Consortium (ISC); Molecular Genetics of Schizophrenia Collaboration (MGS) (2012) Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet 44(3):247-250.
    • (2012) Nat Genet , vol.44 , Issue.3 , pp. 247-250
    • Lee, S.H.1
  • 6
    • 80053132878 scopus 로고    scopus 로고
    • Genome-wide association studies establish that human intelligence is highly heritable and polygenic
    • Davies G, et al. (2011) Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol Psychiatry 16(10):996-1005.
    • (2011) Mol Psychiatry , vol.16 , Issue.10 , pp. 996-1005
    • Davies, G.1
  • 7
    • 84893620601 scopus 로고    scopus 로고
    • Is the gene-environment interaction paradigm relevant to genome-wide studies? The case of education and body mass index
    • Boardman JD, et al. (2014) Is the gene-environment interaction paradigm relevant to genome-wide studies? The case of education and body mass index. Demography 51(1):119-139.
    • (2014) Demography , vol.51 , Issue.1 , pp. 119-139
    • Boardman, J.D.1
  • 8
    • 84923193032 scopus 로고    scopus 로고
    • Still chasing ghosts: A new genetic methodology will not find the "missing heritability"
    • (September 19)
    • Charney E (September 19, 2013) Still chasing ghosts: A new genetic methodology will not find the "missing heritability". Independent Science News.
    • (2013) Independent Science News
    • Charney, E.1
  • 9
    • 55749092742 scopus 로고    scopus 로고
    • Genetics of the framingham heart study population
    • Govindaraju DR, et al. (2008) Genetics of the Framingham heart study population. Adv Genet 62:33-65.
    • (2008) Adv Genet , vol.62 , pp. 33-65
    • Govindaraju, D.R.1
  • 10
    • 34247579476 scopus 로고    scopus 로고
    • The third generation cohort of the national heart, lung, and blood Institute's framingham heart study: Design, recruitment, and initial examination
    • Splansky GL, et al. (2007) The third generation cohort of the national heart, lung, and blood institute's Framingham heart study: Design, recruitment, and initial examination. Am J Epidemiol 165(11):1328-1335.
    • (2007) Am J Epidemiol , vol.165 , Issue.11 , pp. 1328-1335
    • Splansky, G.L.1
  • 11
    • 55849133422 scopus 로고    scopus 로고
    • Efficient methods to compute genomic predictions
    • Van Raden PM (2008) Efficient methods to compute genomic predictions. J Dairy Sci 91(11):4414-4423.
    • (2008) J Dairy Sci , vol.91 , Issue.11 , pp. 4414-4423
    • Van Raden, P.M.1
  • 12
    • 84972496336 scopus 로고
    • That blup is a good thing: The estimation of random effects
    • Robinson GK (1991) That blup is a good thing: The estimation of random effects. Stat Sci 6(1):15-32.
    • (1991) Stat Sci , vol.6 , Issue.1 , pp. 15-32
    • Robinson, G.K.1
  • 13
    • 0000263234 scopus 로고
    • Distribution of eigenvalues for some sets of random matrices
    • Marčenko VA, Pastur LA (1967) Distribution of eigenvalues for some sets of random matrices. Sbornik Mathematics 1(4):457-483.
    • (1967) Sbornik Mathematics , vol.1 , Issue.4 , pp. 457-483
    • Marčenko, V.A.1    Pastur, L.A.2
  • 14
    • 0002247902 scopus 로고
    • The strong limits of random matrix spectra for sample matrices of independent elements
    • Wachter KW (1978) The strong limits of random matrix spectra for sample matrices of independent elements. Ann Probab 6(1):1-18.
    • (1978) Ann Probab , vol.6 , Issue.1 , pp. 1-18
    • Wachter, K.W.1
  • 16
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and population-based linkage analyses
    • Purcell S, et al. (2007) PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81(3):559-575.
    • (2007) Am J Hum Genet , vol.81 , Issue.3 , pp. 559-575
    • Purcell, S.1
  • 18
    • 0037442092 scopus 로고    scopus 로고
    • Population stratification and spurious allelic association
    • Cardon LR, Palmer LJ (2003) Population stratification and spurious allelic association. Lancet 361(9357):598-604.
    • (2003) Lancet , vol.361 , Issue.9357 , pp. 598-604
    • Cardon, L.R.1    Palmer, L.J.2
  • 19
    • 0034686618 scopus 로고    scopus 로고
    • Population stratification in epidemiologic studies of common genetic variants and cancer: Quantification of bias
    • Wacholder S, Rothman N, Caporaso N (2000) Population stratification in epidemiologic studies of common genetic variants and cancer: Quantification of bias. J Natl Cancer Inst 92(14):1151-1158.
    • (2000) J Natl Cancer Inst , vol.92 , Issue.14 , pp. 1151-1158
    • Wacholder, S.1    Rothman, N.2    Caporaso, N.3
  • 20
    • 18344380664 scopus 로고    scopus 로고
    • Selection and use of SNP markers for animal identification and paternity analysis in U.S. Beef cattle
    • Heaton MP, et al. (2002) Selection and use of SNP markers for animal identification and paternity analysis in U.S. beef cattle. Mamm Genome 13(5):272-281.
    • (2002) Mamm Genome , vol.13 , Issue.5 , pp. 272-281
    • Heaton, M.P.1
  • 21
    • 33845630379 scopus 로고    scopus 로고
    • Quantitative trait loci (QTL) mapping of resistance to strongyles and coccidia in the free-living soay sheep (Ovis aries)
    • Beraldi D, et al. (2007) Quantitative trait loci (QTL) mapping of resistance to strongyles and coccidia in the free-living Soay sheep (Ovis aries). Int J Parasitol 37(1): 121-129.
    • (2007) Int J Parasitol , vol.37 , Issue.1 , pp. 121-129
    • Beraldi, D.1
  • 22
    • 57549090341 scopus 로고    scopus 로고
    • Accounting for ancestry: Population substructure and genome-wide association studies
    • Tian C, Gregersen PK, Seldin MF (2008) Accounting for ancestry: Population substructure and genome-wide association studies. Hum Mol Genet 17(R2):R143-R150.
    • (2008) Hum Mol Genet , vol.17 , Issue.R2 , pp. R143-R150
    • Tian, C.1    Gregersen, P.K.2    Seldin, M.F.3
  • 23
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • Price AL, et al. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38(8):904-909.
    • (2006) Nat Genet , vol.38 , Issue.8 , pp. 904-909
    • Price, A.L.1
  • 24
    • 33846006923 scopus 로고    scopus 로고
    • Population structure and eigenanalysis
    • Patterson N, Price AL, Reich D (2006) Population structure and eigenanalysis. PLoS Genet 2(12):e190.
    • (2006) PLoS Genet , vol.2 , Issue.12 , pp. e190
    • Patterson, N.1    Price, A.L.2    Reich, D.3
  • 25
    • 84883461222 scopus 로고    scopus 로고
    • Separation of the largest eigenvalues in eigenanalysis of genotype data from discrete subpopulations
    • Bryc K, Bryc W, Silverstein JW (2013) Separation of the largest eigenvalues in eigenanalysis of genotype data from discrete subpopulations. Theor Popul Biol 89:34-43.
    • (2013) Theor Popul Biol , vol.89 , pp. 34-43
    • Bryc, K.1    Bryc, W.2    Silverstein, J.W.3
  • 27
    • 0033953535 scopus 로고    scopus 로고
    • Risk stratification in hypertension: New insights from the framingham study
    • Kannel WB (2000) Risk stratification in hypertension: New insights from the Framingham Study. Am J Hypertens 13(1 Pt 2):3S-10S.
    • (2000) Am J Hypertens , vol.13 , Issue.1 , pp. 3S-10S
    • Kannel, W.B.1
  • 28
    • 79955811867 scopus 로고    scopus 로고
    • The effect of measurement error of phenotypes on genome wide association studies
    • Barendse W (2011) The effect of measurement error of phenotypes on genome wide association studies. BMC Genomics 12(1):232.
    • (2011) BMC Genomics , vol.12 , Issue.1 , pp. 232
    • Barendse, W.1
  • 29
    • 19944429836 scopus 로고    scopus 로고
    • Recommendations for blood pressure measurement in humans and experimental animals: Part 1: Blood pressure measurement in humans: A statement for professionals from the subcommittee of professional and public education of the American Heart Association council on high blood pressure research
    • Pickering TG, et al.; Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research (2005) Recommendations for blood pressure measurement in humans and experimental animals: Part 1: Blood pressure measurement in humans: A statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension 45(1):142-161.
    • (2005) Hypertension , vol.45 , Issue.1 , pp. 142-161
    • Pickering, T.G.1
  • 30
    • 84904035234 scopus 로고    scopus 로고
    • Estimating quantitative genetic parameters in wild populations: A comparison of pedigree and genomic approaches
    • Bérénos C, Ellis PA, Pilkington JG, Pemberton JM (2014) Estimating quantitative genetic parameters in wild populations: A comparison of pedigree and genomic approaches. Mol Ecol 23(14):3434-3451.
    • (2014) Mol Ecol , vol.23 , Issue.14 , pp. 3434-3451
    • Bérénos, C.1    Ellis, P.A.2    Pilkington, J.G.3    Pemberton, J.M.4
  • 31
    • 66549088006 scopus 로고    scopus 로고
    • On consistency and sparsity for principal components analysis in high dimensions
    • Johnstone IM, Lu AY (2009) On consistency and sparsity for principal components analysis in high dimensions. J Am Stat Assoc 104(486):682-693.
    • (2009) J Am Stat Assoc , vol.104 , Issue.486 , pp. 682-693
    • Johnstone, I.M.1    Lu, A.Y.2
  • 32
    • 70249103304 scopus 로고    scopus 로고
    • PCA consistency in high dimension, low sample size context
    • Jung S, Marron J (2009) PCA consistency in high dimension, low sample size context. Ann Stat 37(6B):4104-4130.
    • (2009) Ann Stat , vol.37 , Issue.6 B , pp. 4104-4130
    • Jung, S.1    Marron, J.2
  • 34
    • 84894540542 scopus 로고    scopus 로고
    • DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12
    • Trzaskowski M, Yang J, Visscher PM, Plomin R (2014) DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12. Mol Psychiatry 19(3):380-384.
    • (2014) Mol Psychiatry , vol.19 , Issue.3 , pp. 380-384
    • Trzaskowski, M.1    Yang, J.2    Visscher, P.M.3    Plomin, R.4
  • 35
    • 84887265151 scopus 로고    scopus 로고
    • Partitioning the heritability of tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture
    • Davis LK, et al. (2013) Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet 9(10): e1003864.
    • (2013) PLoS Genet , vol.9 , Issue.10 , pp. e1003864
    • Davis, L.K.1
  • 36
    • 84883778249 scopus 로고    scopus 로고
    • Additive genetic variation in schizophrenia risk is shared by populations of african and european descent
    • de Candia TR, et al.; International Schizophrenia Consortium; Molecular Genetics of Schizophrenia Collaboration (2013) Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. Am J Hum Genet 93(3): 463-470.
    • (2013) Am J Hum Genet , vol.93 , Issue.3 , pp. 463-470
    • De Candia, T.R.1
  • 37
    • 84879536607 scopus 로고    scopus 로고
    • Refining genetically inferred relationships using treelet covariance smoothing
    • Crossett A, Lee AB, Klei L, Devlin B, Roeder K (2013) Refining genetically inferred relationships using treelet covariance smoothing. Ann Appl Stat 7(2):669-690.
    • (2013) Ann Appl Stat , vol.7 , Issue.2 , pp. 669-690
    • Crossett, A.1    Lee, A.B.2    Klei, L.3    Devlin, B.4    Roeder, K.5
  • 38
    • 84927126442 scopus 로고    scopus 로고
    • Relatedness in the post-genomic era: Is it still useful?
    • Speed D, Balding DJ (2015) Relatedness in the post-genomic era: Is it still useful? Nat Rev Genet 16(1):33-44.
    • (2015) Nat Rev Genet , vol.16 , Issue.1 , pp. 33-44
    • Speed, D.1    Balding, D.J.2
  • 41
    • 51549106256 scopus 로고    scopus 로고
    • On asymptotics of eigenvectors of large sample covariance matrix
    • Bai Z, et al. (2007) On asymptotics of eigenvectors of large sample covariance matrix. Ann Probab 35(4):1532-1572.
    • (2007) Ann Probab , vol.35 , Issue.4 , pp. 1532-1572
    • Bai, Z.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.