Anti-inflammatory, free radical scavenging and alpha-glucosidase inhibitory activities of Hamelia patens and its chemical constituents

Pharmaceutical Biology

Volumn 54, Issue 9, 2016, Pages 1822-1830

  Jiménez Suárez, Verónica ^a   Nieto Camacho, Antonio ^b   Jiménez Estrada, Manuel ^b   Alvarado Sánchez, Brenda ^a  

^a UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

12 tetradecanoylphorbol 13 acetate; Antidiabetic; antioxidant; carrageenan; myeloperoxidase; squalene isomer; stigmasterol; sitosterol

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,6,10,14,18,23 HEXAMETHYL 2,6,10,14,18,22 TETRACOSAHEXAENE; ACETIC ACID ETHYL ESTER; ALPHA GLUCOSIDASE; DICHLOROMETHANE; HAMELIA PATENS EXTRACT; HEXANE; INDOMETACIN; METHANOL; MYELOPEROXIDASE; PHORBOL 13 ACETATE 12 MYRISTATE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; SITOSTEROL; STIGMASTEROL; UNCLASSIFIED DRUG; 1,1-DIPHENYL-2-PICRYLHYDRAZYL; ANTIINFLAMMATORY AGENT; BIPHENYL DERIVATIVE; CARRAGEENAN; GLYCOSIDASE INHIBITOR; PEROXIDASE; PICRIC ACID; SACCHAROMYCES CEREVISIAE PROTEIN; SCAVENGER; SOLVENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CARRAGEENAN-INDUCED PAW EDEMA; CHEMICAL COMPOSITION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; EAR EDEMA; ENZYME INHIBITION; FEMALE; HAMELIA; HAMELIA PATENS; IC50; IN VITRO STUDY; LIQUID LIQUID EXTRACTION; MOUSE; NONHUMAN; RAT; SPECTROSCOPY; STRUCTURE ANALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CHEMISTRY; COMPARATIVE STUDY; DISEASE MODEL; DOSE RESPONSE; EDEMA; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; PHYTOTHERAPY; PLANT LEAF; TIME FACTOR; WISTAR RAT;

ALPHA-GLUCOSIDASES; ANIMALS; ANTI-INFLAMMATORY AGENTS; BIPHENYL COMPOUNDS; CARRAGEENAN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FEMALE; FREE RADICAL SCAVENGERS; GLYCOSIDE HYDROLASE INHIBITORS; HAMELIA; PEROXIDASE; PHYTOTHERAPY; PICRATES; PLANT LEAVES; PLANTS, MEDICINAL; RATS, WISTAR; SACCHAROMYCES CEREVISIAE PROTEINS; SOLVENTS; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS;

EID: 84953249416     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2015.1129544     Document Type: Article

References (43)

1. A.Ahmad, A.Pandurangan, N.Singh, P.Ananad. 2012. A mini review on chemistry and biology of Hamelia Patens (Rubiaceae). Pharmacogn J. 4:1–4.
2. S.Ammar, H.Edziri, M.A.Mahjoub, R.Chatter, A.Bouraoui, Z.Mighri. 2009. Spasmolytic and anti-inflammatory effects of constituents from Hertia cheirifolia. Phytomedicine 16:1156–1161.
3. A.Andrade-Cetto, M.Heinrich 2005. Mexican plants with hypoglycaemic effect used in the treatment of diabetes. J Ethnopharmacol. 99:325–348.
4. R.Aquino, M.L.Ciavatta, F.De Simone, C.Pizza. 1990. A flavanone glycoside from Hamelia patens. Phytochemistry 29:2359–2360.
5. O.Barreiro, P.Martin, R.Gonzalez-Amaro, F.Sanchez-Madrid. 2010. Molecular cues guiding inflammatory responses. Cardiovasc Res. 86:174–182.
6. P.P.Bradley, D.A.Priebat, R.D.Christensen, G.Rothstein. 1982. Measurement of cutaneous inflammation:estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 78:206–209.
7. W.Brand-Williams, M.E.Cuvelier, C.Berset 1995. Use of a free radical method to evaluate antioxidant activity. Food Sci Technol-Leb. 28:25–30.
8. J.B.Calixto, M.F.Otuki, A.R.Santos 2003. Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB). Planta Med. 69:973–983.
9. E.C.Cruz, A.Andrade-Cetto 2015. Ethnopharmacological field study of the plants used to treat type 2 diabetes among the Cakchiquels in Guatemala. J Ethnopharmacol. 159:238–244.
10. P.K.Chaudhuri, R.S.Thakur 1991. Hamelia patens:a new source of ephedrine1. Planta Med. 57:199.
11. P.G.Do Nascimento, T.L.Lemos, A.M.Bizerra, A.M.Arriaga, D.A.Ferreira, G.M.Santiago, R.Braz-Filho, J.G.Costa. 2014. Antibacterial and antioxidant activities of ursolic acid and derivatives. Molecules 19:1317–1327.
12. A.Gomez-Beloz, J.C.Rucinski, M.J.Balick, C.Tipton. 2003. Double incision wound healing bioassay using Hamelia patens from El Salvador. J Ethnopharmacol. 88:169–173.
13. D.Hamdan, M.Z.El-Readi, A.Tahrani, F.Herrmann, D.Kaufmann, N.Farrag, A.El-Shazly, M.Wink. 2011. Chemical composition and biological activity of Citrus jambhiri Lush. Food Chem. 127:394–403.
14. M.Heinrich 2000. Ethnobotany and its role in drug development. Phytother Res. 14:479–488.
15. E.Hernandez-Valle, M.Herrera-Ruiz, G.R.Salgado, A.Zamilpa, M.L.Ocampo, A.J.Aparicio, J.Tortoriello, E.Jimenez-Ferrer. 2014. Anti-inflammatory effect of 3-O-[(6′-O-palmitoyl)-beta-d-glucopyranosyl sitosterol] from Agave angustifolia on ear edema in mice. Molecules 19:15624–15637.
16. A.Ju, Y.C.Cho, S.Cho 2015. Methanol extracts of Xanthium sibiricum roots inhibit inflammatory responses via the inhibition of nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription 3 (STAT3) in murine macrophages. J Ethnopharmacol 174:74–81.
17. J.Korbecki, I.Baranowska-Bosiacka, I.Gutowska, D.Chlubek. 2013. The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid. J Physiol Pharmacol. 64:409–421.
18. A.Kumar, R.Kaur, S.Arora 2010. Free radical scavenging potential of some Indian medicinal plants. J Med Plants Res. 4:2034–2042.
19. S.Kumar, V.Kumar, O.Prakash 2013. Enzymes inhibition and antidiabetic effect of isolated constituents from Dillenia indica. Biomed Res Int. 2013:382063.
20. S.Kumar, S.Narwal, V.Kumar, O.Prakash. 2011. α-Glucosidase inhibitors from plants:a natural approach to treat diabetes. Pharmacogn Rev. 5:19–29.
21. M.Leonti, H.Vibrans, O.Sticher, M.Heinrich. 2001. Ethnopharmacology of the Popoluca, Mexico:an evaluation. J Pharm Pharmacol. 53:1653–1669.
22. C.Li, F.Xi, J.Mi, Z.Wu, W.Chen. 2013. Two new 3,4;9,10-seco-cycloartane type triterpenoids from Illicium difengpi and their anti-inflammatory activities. Evid Based Complement Alternat Med. 2013:942541.
23. U.Mahmood, V.K.Kaul, B.Singh 2002. Sesquiterpene and long chain ester from Tanacetum longifolium. Phytochemistry 61:913–917.
24. D.Martins, C.V.Nunez 2015. Secondary metabolites from Rubiaceae species. Molecules 20:13422–13495.
25. M.J.Morgan, Z.-G.Liu 2011. Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res. 21:103–115.
26. A.Navarro, B.Delas Heras, A.Villar 2001. Anti-inflammatory and immunomodulating properties of a sterol fraction from Sideritis foetens Clem. Biol Pharm Bull. 24:470–473.
27. S.A.Nirmal, S.C.Pal, S.C.Mandal, A.N.Patil. 2012. Analgesic and anti-inflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves. Inflammopharmacology 20:219–224.
28. I.G.Otterness, E.H.Wiseman, D.J.Gans 1979. A comparison of the carrageenan edema test and ultraviolet light-induced erythema test as predictors of the clinical dose in rheumatoid arthritis. Agents Actions 9:177–183.
29. D.Paniagua-Vega, C.M.Cerda-Garcia-Rojas, T.Ponce-Noyola, A.C.Ramos-Valdivia. 2012. A new monoterpenoid oxindole alkaloid from Hamelia patens micropropagated plantlets. Nat Prod Commun. 7:1441–1444.
30. P.Rajendran, N.Nandakumar, T.Rengarajan, R.Palaniswami, E.N.Gnanadhas, U.Lakshminarasaiah, J.Gopas, I.Nishigaki. 2014. Antioxidants and human diseases. Clin Chim Acta. 436:332–347.
31. A.Ramos, A.Visozo, J.Piloto, A.Garcia, C.A.Rodriguez, R.Rivero. 2003. Screening of antimutagenicity via antioxidant activity in Cuban medicinal plants. J Ethnopharmacol. 87:241–246.
32. R.Reyes-Chilpa, J.Rivera, M.Oropeza, P.Mendoza, B.Amekraz, C.Jankowski, M.Campos. 2004. Methanol extracts of Hamelia patens containing oxindole alkaloids relax KCl-induced contraction in rat myometrium. Biol Pharm Bull. 27:1617–1620.
33. M.Y.Rios, A.B.Aguilar-Guadarrama 2006. Indolic alkaloids, terpenes, sterols and flavonoids from the leaves of Hamelia patens Jacquin (Rubiaceae). Rev Cubana Plant Med. 11:1–4.
34. H.Ripperger 1977. Isolation of isopteropodin from Hamelia patens. Pharmazie 32:415–416.
35. H.Ripperger 1978. Isolation of stigmast-4-ene-3,6-dione from Hamelia patens and Clitoria ternatea. Pharmazie 33:82–83.
36. F.Ruiz-Terán, A.Medrano-Martínez, A.Navarro-Ocaña 2008. Antioxidant and free radical scavenging activities of plant extracts used in traditional medicine in Mexico. Afr J Biotechnol. 7:1886–1893.
37. S.Sanchez-Fidalgo, I.Villegas, M.A.Rosillo, M.Aparicio-Soto, C.A.De la Lastra. 2015. Dietary squalene supplementation improves DSS-induced acute colitis by downregulating p38 MAPK and NFκB signaling pathways. Mol Nutr Food Res. 59:284–292.
38. S.Sosa, M.J.Balick, R.Arvigo, R.G.Esposito, C.Pizza, G.Altinier, A.Tubaro. 2002. Screening of the topical anti-inflammatory activity of some Central American plants. J Ethnopharmacol. 81:211–215.
39. K.Subrahmanyam, J.Rao, K.Rao 1973. Short scientific notes:chemical examination of Hamelia patens (Rubiaceae). Curr Sci. 42:841.
40. S.S.Syed Hussein, M.N.Alfarizal Kamarudin, H.A.Kadir 2015. (+)-Catechin attenuates NF-kappaB activation through regulation of Akt, MAPK, and AMPK signaling pathways in LPS-induced BV-2 microglial cells. Am J Chin Med. 43:927–952.
41. C.A.Winter, E.A.Risley, G.W.Nuss 1962. Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc Soc Exp Biol Med. 111:544–547.
42. H.Xu, M.Zhang, X.L.Li, H.Li, L.T.Yue, X.X.Zhang, C.C.Wang, S.Wang, R.S.Duan. 2015. Low and high doses of ursolic acid ameliorate experimental autoimmune myasthenia gravis through different pathways. J Neuroimmunol. 281:61–67.
43. J.M.Young, B.M.Wagner, D.A.Spires 1983. Tachyphylaxis in 12-O-tetradecanoylphorbol acetate-and arachidonic acid-induced ear edema. J Invest Dermatol. 80:48–52.