Direct suppression of pth gene expression by the vitamin D prohormones doxercalciferol and calcidiol requires the vitamin D receptor

Journal of Molecular Endocrinology

Volumn 46, Issue 2, 2011, Pages 63-66

  Ritter, Cynthia S ^a   Brown, Alex J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIDIOL; DOXERCALCIFEROL; HORMONE PRECURSOR; PARATHYROID HORMONE; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D RECEPTOR;

ANIMAL TISSUE; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; ORGAN CULTURE; PARATHYROID GLAND; PARATHYROID HORMONE RELEASE; PRIORITY JOURNAL; TRANSGENIC ANIMAL; WILD TYPE;

ANIMALS; CALCIFEDIOL; CALCITRIOL; ERGOCALCIFEROLS; GENE EXPRESSION; GENE EXPRESSION REGULATION; MICE; MICE, TRANSGENIC; ORGAN CULTURE TECHNIQUES; PARATHYROID GLANDS; PARATHYROID HORMONE; RECEPTORS, CALCITRIOL; TRANSCRIPTION, GENETIC;

EID: 79953715634     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-10-0128     Document Type: Article

References (15)

1. Adams JS, Chen H, Chun R, Gacad MA, Encinas C, Ren S, Nguyen L, Wu S, Hewison M & Barsony J 2004 Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism. Journal of Steroid Biochemistry and Molecular Biology 89-90 461-465. (doi:10. 1016/j.jsbmb.2004.03.016)
2. Brown AJ, Ritter CS, Knutson JC & Strugnell SA 2006 The vitamin D prodrugs 1alpha(OH)D2, 1alpha(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells. Nephrology, Dialysis, Transplantation 21 644-650. (doi:10.1093/ndt/gfi186)
3. Chun RF, Gacad M, Nguyen L, Hewison M & Adams JS 2007 Co-chaperone potentiation of vitamin D receptor-mediated transacti-vation: a role for Bcl2-associated athanogene-1 as an intracellular-binding protein for 1,25-dihydroxyvitamin D3. Journal of Molecular Endocrinology 39 81-89. (doi:10.1677/JME-07-0042)
4. Koszewski NJ, Ashok S & Russell J 1999 Turning a negative into a positive: vitamin D receptor interactions with the avian parathyroid hormone response element. Molecular Endocrinology 13 455-465. (doi:10.1210/me.13.3.455)
5. Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R & Demay MB 1997 Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. PNAS 94 9831-9835. (doi:10.1073/pnas.94.18.9831)
6. Mackey SL,Heymont JL, Kronenberg HM & Demay MB 1996 Vitamin D receptor binding to the negative human parathyroid hormone vitamin D response element does not require the retinoid X receptor. Molecular Endocrinology 10 298-305. (doi:10.1210/me.10.3.298)
7. Murayama A, Kim MS, Yanagisawa J, Takeyama K & Kato S 2004 Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching. EMBO Journal 23 1598-1608. (doi:10.1038/sj.emboj.7600157)
8. Norman AW, Ishizuka S & Okamura WH 2001 Ligands for the vitamin D endocrine system: different shapes function as agonists and antagonists for genomic and rapid response receptors or as a ligand for the plasma vitamin D binding protein. Journal of Steroid Biochemistry and Molecular Biology 76 49-59. (doi:10.1016/S0960-0760(00)00145-X)
9. Okamura WH & Zhu GD 1997 Chemistry and design: structural biology of vitamin D action. In Vitamin D, pp 939-971. Eds D Feldman, FH Glorieux & JW Pike. San Diego: Academic Press.
10. Panda DK, Miao D, Bolivar I, Li J, Huo R, Hendy GN & Goltzman D 2004 Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. Journal of Biological Chemistry 279 16754-16766. (doi:10.1074/jbc.M310271200)
11. Ritter CS, Armbrecht HJ, Slatopolsky E & Brown AJ 2006 25-Hydroxyvitamin D(3) suppresses PTH synthesis and secretion by bovine parathyroid cells. Kidney International 70 654-659. (doi:10.1038/sj.ki.5000394)
12. 2+ and the calcimimetic R-568 in parathyroid cells: role of cytosolic Ca and requirement for gene transcription. Journal of Molecular Endocrinology 40 13-21. (doi:10.1677/JME-07-0085)
13. Russell J & Sherwood LM 1987 The effects of 1,25-dihydroxyvitamin D3 and high calcium on transcription of the pre-proparathyroid hormone gene are direct. Transactions of the Association of American Physicians 100 256-262.
14. Russell J, Lettieri D & Sherwood LM 1986 Suppression by 1,25(OH)2D3 of transcription of the pre-proparathyroid hormone gene. Endocrinology 119 2864-2866. (doi:10.1210/endo-119-6-2864)
15. Silver J, Naveh-Many T, Mayer H, Schmelzer HJ & Popovtzer MM 1986 Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat. Journal of Clinical Investigation 78 1296-1301. (doi:10.1172/JCI112714)