Vitamin D does not increase calcium absorption in young women: A randomized clinical trial

Journal of Bone and Mineral Research

Volumn 29, Issue 5, 2014, Pages 1081-1087

  Gallagher, J Christopher ^a   Jindal, Prachi S ^a   Smith, Lynette M ^b  

^a CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

25OHD; calcium absorption; vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; CITRATE CALCIUM; COLECALCIFEROL; PLACEBO; 25-HYDROXYVITAMIN D; VITAMIN D;

ADULT; AFRICAN AMERICAN; ARTICLE; CALCIUM ABSORPTION; CALCIUM INTAKE; CALCIUM TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; EUROPEAN AMERICAN; FEMALE; HUMAN; MAJOR CLINICAL STUDY; OSTEOMALACIA; RANDOMIZED CONTROLLED TRIAL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; ANALOGS AND DERIVATIVES; BLOOD; CAUCASIAN; MIDDLE AGED;

ADULT; AFRICAN AMERICANS; CALCIUM; DOUBLE-BLIND METHOD; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; MIDDLE AGED; VITAMIN D;

EID: 84899067280     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2121     Document Type: Article

References (26)

1. Institute of Medicine dietary reference intakes for calcium and vitamin D. Washington, DC: National Academies Press; 2011.
2. Kinyamu HK, Gallagher JC, Petranick KM, Ryschon KL,. Effect of parathyroid hormone (hPTH[1-34]) infusion on serum 1,25dihydroxyvitamin D and parathyroid hormone in normal women. J Bone Miner Res. 1996; 1 (10): 1400-5.
3. Shimada T, Hasegawa H, Yamazaki Y, et al. FGF-23 is a potent regulator of vitamin D metabolism. J Bone Miner Res. 2004; 19: 429-35.
4. Hoenderop JG, Nilius B, Bindels RJ,. Calcium absorption across epithelia. Physiol Rev. 2005; 85: 373-422.
5. Norman AW,. Intestinal calcium absorption: a vitamin D-hormone-mediated adaptive response. Am J Clin Nutr. 1990; 51 (2): 290-300.
6. Favus MJ,. Factors that influence absorption and secretion of calcium in the small intestine and colon. Am J Physiol. 1985; 248: G147-57.
7. Fujita H, Sugimoto K, Inatomi S, et al. Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Mol Biol Cell. 2008; 19: 1912-21.
8. Yoshizawa T, Handa Y, Uematsu Y, et al. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet. 1997; 16: 391-6.
9. Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, DeLuca HF,. Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. J Clin Invest. 1979; 64 (3): 729-73.
10. Nicolaysen R, Eeg-Larsen N, Malm OJ,. Physiology of calcium metabolism. Physiol Rev. 1953; 33 (3): 424-44.
11. Birge SJ, Peck WA, Berman M, Whedon GD,. Study of calcium absorption in man: a kinetic analysis and physiologic model. J Clin Invest. 1969; 48 (9): 1705-13.
12. Nordin BE, Morris HA,. Recalculation of the calcium requirement of adult men. Am J Clin Nutr. 2011; 93 (2): 442-5.
13. Tsai KS,. Heath H 3rd, Kumar R, Riggs BL. Impaired vitamin D metabolism with aging in women. Possible role in pathogenesis of senile osteoporosis. J Clin Invest. 1984; 73 (6): 1668-72.
14. Francis RM, Peacock M, Taylor GA, Storer JH, Nordin BE,. Calcium malabsorption in elderly women with vertebral fractures: evidence for resistance to the action of vitamin D metabolites on the bowel. Clin Sci (Lond). 1984; 66 (1): 103-7.
15. Wood RJ, Fleet JC, Cashman K, Bruns ME, Deluca HF,. Intestinal calcium absorption in the aged rat: evidence of intestinal resistance to 1,25(OH)2 vitamin D. Endocrinology. 1998; 139: 3843-8.
16. Gallagher CJ, Jindal PS, Smith LM,. Vitamin D supplementation in young Caucasian and African American women. J Bone Miner Res. 2013 Jun 12. [Epub ahead of print].
17. Carter GD, Berry JL, Gunter E, et al. Proficiency testing of 25-hydroxyvitamin D (25-OHD) assays. J Steroid Biochem Mol Biol. 2010; 121 (1-2): 176-9.
18. National Institute of Standards and Technology. NIST releases vitamin D standard reference material. 2009. Jul 14. Available from: http://www.nist.gov/ mml/csd/vitamind-071409.cfm.
19. Marshall DH, Nordin BE,. A comparison of radioactive calcium absorption tests with net calcium absorption. Clin Sci (Lond). 1981; 61 (4): 477-81.
20. Gallagher JC, Yalamanchilli V, Smith LM,. The effect of vitamin D on calcium absorption in older women. J Clin Endocrinol Metab. 2012; 97 (10): 3550-6.
21. Park CY, Hill KM, Elble AE, et al. Daily supplementation with 25 μg cholecalciferol does not increase calcium absorption or skeletal retention in adolescent girls with low serum 25-hydroxyvitamin D. J Nutr. 2010; 140 (12): 2139-44.
22. Abrams SA, Hawthorne KM, Chen Z,. Supplementation with 1000 IU vitamin D/d leads to parathyroid hormone suppression, but not increased fractional calcium absorption, in 4-8-y-old children: a double-blind randomized controlled trial. Am J Clin Nutr. 2013; 97 (1): 217-23.
23. Aloia JF, Chen DG, Yeh JK, Chen H,. Serum vitamin D metabolites and intestinal calcium absorption efficiency in women. Am J Clin Nutr. 2010; 92: 835-84.
24. Sai AJ, Walters RW, Fang X, Gallagher JC,. Relationship between vitamin D, parathyroid hormone, and bone health. J Clin Endocrinol Metab. 2011; 96 (3): E436-46.
25. Need AG, O'Loughlin PD, Morris HA, Coates PS, Horowitz M, Nordin BE,. Vitamin D metabolites and calcium absorption in severe vitamin D deficiency. J Bone Miner Res. 2008; 23 (11): 1859-63.
26. Dawson-Hughes B, Harris S, Kramich C, Dallal G, Rasmussen HM,. Calcium retention and hormone levels in black and white women on high- and low-calcium diets. J Bone Miner Res. 1993; 8 (7): 779-87.