Incorporating Informatics for Integrating Biology and the Bedside (i2b2) into Predoctoral Trainee Curriculum to Evaluate Student-Generated Hypotheses

Clinical and Translational Science

Volumn 8, Issue 6, 2015, Pages 729-733

  Schieffer, Kathleen M ^a,b   Peters, Douglas G ^a,b   Richter, Chesney K ^a   Loc, Welley S ^a   Pawelczyk, James A ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Anemia nutritional; Attention deficit hyperactivity disorder; Bioinformatics; Cobalamin; Folate < anemia; Iron; Medical records; Predoctoral

Indexed keywords

ADOLESCENT; AFRICAN AMERICAN; ARTICLE; ATTENTION DEFICIT DISORDER; CAUCASIAN; CHILD; CONTROLLED STUDY; CURRICULUM; DATA BASE; DISEASE ASSOCIATION; DOCTORAL EDUCATION; ETHNICITY; HUMAN; INFORMATICS FOR INTEGRATING BIOLOGY AND THE BEDSIDE DATABASE; IRON DEFICIENCY ANEMIA; MEDICAL EXPERT; MEDICAL STUDENT; PRIORITY JOURNAL; RACE DIFFERENCE; CANCER REGISTRY; COMPLICATION; EDUCATION; ELECTRONIC HEALTH RECORD; FEMALE; MALE; MEDICAL INFORMATICS; METHODOLOGY; NATIONAL HEALTH ORGANIZATION; PENNSYLVANIA; PRESCHOOL CHILD; PREVALENCE; PROCEDURES; TRANSLATIONAL RESEARCH; UNITED STATES; VIRGINIA;

ADOLESCENT; ANEMIA, IRON-DEFICIENCY; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CHILD, PRESCHOOL; CURRICULUM; ELECTRONIC HEALTH RECORDS; FEMALE; HUMANS; MALE; MEDICAL INFORMATICS; NATIONAL INSTITUTES OF HEALTH (U.S.); PENNSYLVANIA; PREVALENCE; RESEARCH DESIGN; SEER PROGRAM; STUDENTS, MEDICAL; TRANSLATIONAL MEDICAL RESEARCH; UNITED STATES; VIRGINIA;

EID: 84952988031     PISSN: 17528054     EISSN: 17528062     Source Type: Journal    
DOI: 10.1111/cts.12357     Document Type: Article

References (37)

1. Committee to Review the Clinical and Translational Science Awards Program at the National Center for Advancing Translational Sciences, Board on Health Sciences Policy, Institute of Medicine. In: Leshner AI, Terry SF, Schultz AM, Liverman CT, eds. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research. Washington DC: National Academies Press (US); 2013: 2-5.
2. Radlowski EC, Johnson RW. Perinatal iron deficiency and neurocognitive development. Front Hum Neurosci. 2013; 7: 585.
3. Rytych JL, Elmore MRP, Burton MD, Conrad MS, Donovan SM, Dilger RN, Johnson RW. Early life iron deficiency impairs spatial cognition in neonatal piglets. J Nutr. 2012; 142: 2050-2056.
4. Murphy SN, Mendis M, Hackett K, Kuttan R, Pan W, Phillips LC, Gainer V, Berkowicz D, Glaser JP, Kohane I, et al. Architecture of the open-source clinical research chart from Informatics for Integrating Biology and the Bedside. AMIA Annu Symp Proc. 2007; 2007: 548-552.
5. Murphy SN, Mendis ME, Berkowitz DA, Kohane I, Chueh HC. Integration of clinical and genetic data in the i2b2 architecture. AMIA Annu Symp Proc. 2006; 2006: 1040.
6. Penn State Hershey Medical Center 2014 Annual Report. Penn State Hershey website. http://www.pennstatehershey.org/documents/10100/15045/2014+Annual+Report+-+Inspiration/c737e5e9-a9c3-4b35-be54-537a11c024ef. 2014. Accessed July 5, 2015.
7. VCU Medical Center 2013 Annual Report. Virginia Commonwealth University Medical Center website. http://www.annualreports.vcu.edu/medical/pdf/medcenter2013_annualreport.pdf. 2013. Accessed July 5, 2015.
8. QuickFacts Beta United States. United States Census Bureau website. http://www.census.gov/quickfacts/table/PST045214/00. Accessed April 29, 2015.
9. Who Is at Risk for Anemia? NHLBI website. https://www.nhlbi.nih.gov/health/health-topics/topics/anemia/atrisk. May 18, 2012. Accessed April 19, 2015.
10. Chenoufi N, Loréal O, Drénou B, Cariou S, Hubert N, Leroyer P, Brissot P, Lescoat G. Iron may induce both DNA synthesis and repair in rat hepatocytes stimulated by EGF/pyruvate. J Hepatol. 1997; 26: 650-658.
11. Zhang C. Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control. Protein Cell. 2014; 5: 750-760.
12. Beard J. Iron deficiency alters brain development and functioning. J Nutr. 2003; 133: 1468S-1472S.
13. Jorgenson LA, Wobken JD, Georgieff MK. Perinatal iron deficiency alters apical dendritic growth in hippocampal CA1 pyramidal neurons. Dev Neurosci. 2003; 25: 412-420.
14. Jorgenson LA, Sun M, O'Connor M, Georgieff MK. Fetal iron deficiency disrupts the maturation of synaptic function and efficacy in area CA1 of the developing rat hippocampus. Hippocampus. 2005; 15: 1094-1102.
15. Yu GS, Steinkirchner TM, Rao GA, Larkin EC. Effect of prenatal iron deficiency on myelination in rat pups. Am J Pathol. 1986; 125: 620-624.
16. Todorich B, Zhang X, Connor JR. H-ferritin is the major source of iron for oligodendrocytes. Glia. 2011; 59: 927-935.
17. Espinosa de los Monteros A, Kumar S, Zhao P, Huang CJ, Nazarian R, Pan T, Scully S, Chang R, de Vellis J. Transferrin is an essential factor for myelination. Neurochem Res. 1999; 24: 235-248.
18. Badaracco ME, Ortiz EH, Soto EF, Connor J, Pasquini JM. Effect of transferrin on hypomyelination induced by iron deficiency. J Neurosci Res. 2008; 86: 2663-2673.
19. Fretham SJB, Carlson ES, Georgieff MK. The role of iron in learning and memory. Adv Nutr. 2011; 2: 112-121.
20. Oner P, Oner O. Relationship of ferritin to symptom ratings children with attention deficit hyperactivity disorder: effect of comorbidity. Child Psychiatr Hum Dev. 2007; 39: 323-330.
21. Calarge C, Farmer C, DiSilvestro R, Arnold LE. Serum ferritin and amphetamine response in youth with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2010; 20: 495-502.
22. Chen M-H, Su T-P, Chen Y-S, Hsu J-W, Huang K-L, Chang W-H, Chen T-J, Bai Y-M. Association between psychiatric disorders and iron deficiency anemia among children and adolescents: a nationwide population-based study. BMC Psychiatr. 2013; 13: 161.
23. Abbas E, Valli S. Iron deficiency anaemia in children with ADHD. Arch Dis Child. 2012; 97: A93-A94.
24. Lahat E, Heyman E, Livne A, Goldman M, Berkovitch M, Zachor D. Iron deficiency in children with attention deficit hyperactivity disorder. Isr Med Assoc J. 2011; 13: 530-533.
25. Konofal E, Lecendreux M, Deron J, Marchand M, Cortese S, Zaïm M, Mouren MC, Arnulf I. Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr Neurol. 2008; 38: 20-26.
26. Bener A, Kamal M, Bener H, Bhugra D. Higher prevalence of iron deficiency as strong predictor of attention deficit hyperactivity disorder in children. Ann Med Health Sci Res. 2014; 4: S291-S297.
27. American Psychiatric Association. American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disordrs, 5th edn. Arlington, VA: American Psychiatric Publishing; 2013.
28. Konofal E, Lecendreux M, Arnulf I, Mouren M-C. Iron deficiency in children with attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med. 2004; 158: 1113-1115.
29. Sever Y, Ashkenazi A, Tyano S, Weizman A. Iron treatment in children with attention deficit hyperactivity disorder. A preliminary report. Neuropsychobiology. 1997; 35: 178-180.
30. Sachdev H, Gera T, Nestel P. Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutr. 2005; 8: 117-132.
31. Logan S, Martins S, Gilbert R. Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia. Cochr Datab Syst Rev. 2001; (2): CD001444.
32. Metallinos-Katsaras E, Valassi-Adam E, Dewey KG, Lönnerdal B, Stamoulakatou A, Pollitt E. Effect of iron supplementation on cognition in Greek preschoolers. Eur J Clin Nutr. 2004; 58: 1532-1542.
33. Bruner AB, Joffe A, Duggan AK, Casella JF, Brandt J. Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet. 1996; 348: 992-996.
34. Millichap JG, Yee MM, Davidson SI. Serum ferritin in children with attention-deficit hyperactivity disorder. Pediatr Neurol. 2006; 34: 200-203.
35. Donfrancesco R, Parisi P, Vanacore N, Martines F, Sargentini V, Cortese S. Iron and ADHD: time to move beyond serum ferritin levels. J Atten Disord. 2013; 17: 347-357.
36. Visser SN, Danielson ML, Bitsko RH, Holbrook JR, Kogan MD, Ghandour RM, Perou R, Blumberg SJ. Trends in the parent-report of health care provider-diagnosed and medicated attention-deficit/hyperactivity disorder: United States, 2003-2011. J Am Acad Child Adolesc Psychiatr. 2014; 53: 34-46.e2.
37. US Centers for Disease Control and Prevention. Summary Health Statistics for U.S. Children: National Health Interview Survey 2012. Vital Heal Stat. 2013; 10: 1-73.