Effect of metformin on early pregnancy loss in women with polycystic ovary syndrome

Taiwanese Journal of Obstetrics and Gynecology

Volumn 54, Issue 3, 2015, Pages 266-269

  Al Biate, Mawahib A S ^a  

^a GULF MEDICAL UNIVERSITY   (United Arab Emirates)

Author keywords

Early pregnancy loss; Insulin resistance; Metformin; Polycystic ovary syndrome

Indexed keywords

ANTIBODY; CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN BETA SUBUNIT; CLOMIFENE CITRATE; METFORMIN; TESTOSTERONE; ANTIDIABETIC AGENT;

ADULT; ARTICLE; BODY MASS; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EARLY PREGNANCY LOSS; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; MAJOR CLINICAL STUDY; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE; PREGNANCY; PREGNANCY OUTCOME; PREGNANT WOMAN; PROSPECTIVE STUDY; SPONTANEOUS ABORTION; THYROID FUNCTION TEST; TRANSVAGINAL ECHOGRAPHY; ABORTION, SPONTANEOUS; POLYCYSTIC OVARY SYNDROME; RECURRENT DISEASE;

ABORTION, SPONTANEOUS; ADULT; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PROSPECTIVE STUDIES; RECURRENCE;

EID: 84952872930     PISSN: 10284559     EISSN: 18756263     Source Type: Journal    
DOI: 10.1016/j.tjog.2013.06.020     Document Type: Article

References (34)

1. Achard C., Theirs J. Le virilisme pilaire et son association a l'insuffisance glycolytique (diabete a femmes de barbe). [Association of hirsutism and diabetes (diabetes of women with a beard)]. Bull Acad Natl Med 1921, 86:51-83. [In French].
2. Balen A.H., Tan S.L., MacDougall J., Jacobs H.S. Miscarriage rates following in vitro fertilization are increased in women with polycystic ovaries and reduced by pituitary desensitization with buserelin. Hum Reprod 1993, 8:959-964.
3. Sagle M., Bishop K., Ridley N., Alexander F.M., Michel M., Bonney R.C., et al. Recurrent early miscarriage and polycystic ovaries. BMJ 1988, 297:1027-1028.
4. Carmina E., Koyama T., Chang L., Stanczyk F.Z., Lobo R.A. Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome?. Am J Obstet Gynecol 1992, 167:1807-1812.
5. Dunaif A., Segal K.R., Futterweit W., Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 1989, 38:1165-1174.
6. Moghetti P., Castello R., Negri C., Tosi F., Perrone F., Caputo M., et al. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J Clin Endocrinol Metab 2000, 85:139-146.
7. Nestler J.E., Jakubowicz D.J., Evans W.S., Pasquali R. Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med 1998, 338:1876-1880.
8. Nestler J.E., Jakubowicz D.J. Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 alpha activity and serum androgens. J Clin Endocrinol Metab 1997, 82:4075-4079.
9. Jakubowicz D.J., Iuorno M.J., Jakubowicz S., Roberts K.A., Nestler J.E. Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab 2002, 87:524-529.
10. Tulppala M., Stenman U.H., Cacciatore B., Ylikorkala O. Polycystic ovaries and levels of gonadotrophins and androgens in recurrent miscarriage: prospective study in 50 women. Br J Obstet Gynaecol 1993, 100:348-352.
11. Velazquez E.M., Mendoza S., Hamer T., Sosa F., Glueck C.J. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 1994, 43:647-654.
12. Coetzee E.J., Jackson W.P. Metformin in management of pregnant insulin-independent diabetics. Diabetologia 1979, 16:241-245.
13. Coetzee E.J., Jackson W.P. Oral hypoglycaemics in the first trimester and fetal outcome. S Afr Med J 1984, 65:635-637.
14. Coetzee E.J., Jackson W.P. The management of non-insulin-dependent diabetes during pregnancy. Diabetes Res Clin Pract 1985-1986, 1:281-287.
15. Akbar D.H. Effect of metformin and sulfonylurea on C-reactive protein level in well-controlled type 2 diabetics with metabolic syndrome. Endocrine 2003, 20:215-218.
16. Hellmuth E., Damm P., Mølsted-Pedersen L. Oral hypoglycaemic agents in 118 diabetic pregnancies. Diabet Med 2000, 17:507-511.
17. Kyei-Mensah A., Zaidi J., Campbell S. Ultrasound diagnosis of polycystic ovary syndrome. Baillieres Clin Endocrinol Metab 1996, 10:249-262.
18. Waddell RS. Home pregnancy test hCG levels and FAQ. Available at:. [Accessed 11 May 2015]. http://www.fertilityplus.com/.
19. Royal College of Obstetricians and Gynecologists The management of Tubal pregnancy (No. 21) 2004, Royal College of Obstetricians and Gynecologists, London.
20. Jakubowicz D.J., Seppälä M., Jakubowicz S., Rodriguez-Armas O., Rivas-Santiago A., Koistinen H., et al. Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome. J Clin Endocrinol Metab 2001, 86:1126-1133.
21. Glueck C.J., Goldenberg N., Wang P., Loftspring M., Sherman A. Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout pregnancy. Hum Reprod 2004, 19:510-521.
22. Diamanti-Kandarakis E., Kouli C., Tsianateli T., Bergiele A. Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome. Eur J Endocrinol 1998, 138:269-274.
23. Glueck C.J., Phillips H., Cameron D., Sieve-Smith L., Wang P. Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study. Fertil Steril 2001, 75:46-52.
24. Motta A.B. Dehydroepiandrosterone to induce murine models for the study of polycystic ovary. J Steroid Biochem Mol Biol 2010, 119:105-111.
25. Baillargeon J.P. Use of insulin sensitizers in polycystic ovarian syndrome. Curr Opin Investig Drugs 2005, 6:1012-1022.
26. Chu N.V., Kong A.P., Kim D.D., Armstrong D., Baxi S., Deutsch R., et al. Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes. Diabetes Care 2002, 25:542-549.
27. Nagi D.K., Yudkin J.S. Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects. A study of two ethnic groups. Diabetes Care 1993, 16:621-629.
28. Bolton A.E., Pockley A.G., Clough K.J., Mowles E.A., Stoker R.J., Westwood O.M., et al. Identification of placental protein 14 as an immunosuppressive factor in human reproduction. Lancet 1987, 1:593-595.
29. Okamoto N., Uchida A., Takakura K., Kariya Y., Kanzaki Y., Riittinen L., et al. Suppression by human placental protein 14 of natural killer cell activity. Am J Reprod Immunol 1991, 26:137-142.
30. Giudice L.C., Mark S.P., Irwin J.C. Paracrine actions of insulin-like growth factors and IGF binding protein-1 in non-pregnant human endometrium and at the decidual-trophoblast interface. J Reprod Immunol 1998, 39:133-148.
31. Sarlis N.J., Weil S.J., Nelson L.M. Administration of metformin to a diabetic woman with extreme hyperandrogenemia of nontumoral origin: management of infertility and prevention of inadvertent masculinization of a female fetus. J Clin Endocrinol Metab 1999, 84:1510-1512.
32. Vanky E., Salvesen K.A., Heimstad R., Fougner K.J., Romundstad P., Carlsen S.M., et al. Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study. Hum Reprod 2004, 19:1734-1740.
33. Fedorcsák P., Storeng R., Dale P.O., Tanbo T., Abyholm T. Obesity is a risk factor for early pregnancy loss after IVF or ICSI. Acta Obstet Gynecol Scand 2000, 79:43-48.
34. Hall G.M., Nicholson G. Current therapeutic drugs for type 2 diabetes, still useful after 50 years?. Anesth Analg 2009, 108:1727-1730.