T Cell Intrinsic USP15 Deficiency Promotes Excessive IFN-γ Production and an Immunosuppressive Tumor Microenvironment in MCA-Induced Fibrosarcoma

Cell Reports

Volumn 13, Issue 11, 2015, Pages 2470-2479

  Zou, Qiang ^a,b   Jin, Jin ^b,d   Xiao, Yichuan ^a,b   Zhou, Xiaofei ^b   Hu, Hongbo ^b,e   Cheng, Xuhong ^b   Kazimi, Nasser ^b   Ullrich, Stephen E ^b,c   Sun, Shao Cong ^b,c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d ZHEJIANG UNIVERSITY   (China)

^e SICHUAN UNIVERSITY   (China)

Author keywords

IFN ; Immunosuppression; T cells; Tumor microenvironment; USP15

Indexed keywords

3 METHYLCHOLANTHRENE; DEUBIQUITINASE; GAMMA INTERFERON; PROGRAMMED DEATH 1 LIGAND 1; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; USP15 PROTEIN; CD11B ANTIGEN; CD274 PROTEIN, MOUSE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; NEUTRALIZING ANTIBODY; USP15 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CARCINOGENESIS; ENZYME DEFICIENCY; FIBROSARCOMA; IMMUNE DEFICIENCY; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SUPPRESSOR CELL; T LYMPHOCYTE; TUMOR MICROENVIRONMENT; ANIMAL; CD4+ T LYMPHOCYTE; CHEMICALLY INDUCED; DEFICIENCY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MORTALITY; PATHOLOGY; SIGNAL TRANSDUCTION; SURVIVAL RATE; TH1 CELL; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD11B; ANTIGENS, CD274; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CHEMOKINE CXCL12; FIBROSARCOMA; FORKHEAD TRANSCRIPTION FACTORS; INTERFERON-GAMMA; METHYLCHOLANTHRENE; MICE; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; SURVIVAL RATE; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TUMOR MICROENVIRONMENT; UBIQUITIN-SPECIFIC PROTEASES;

EID: 84952871206     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.11.046     Document Type: Article

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