메뉴 건너뛰기




Volumn 69, Issue 2, 2016, Pages 311-323

Cardiovascular Safety of β3-adrenoceptor Agonists for the Treatment of Patients with Overactive Bladder Syndrome

Author keywords

Cardiovascular; Overactive bladder; Safety; 3 Adrenoceptor agonist

Indexed keywords

4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID METHYL ESTER; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; MIRABEGRON; RAFABEGRON; RITOBEGRON; SOLABEGRON; TAMSULOSIN; TOLTERODINE; ACETANILIDE DERIVATIVE; ANILINE DERIVATIVE; BENZOIC ACID DERIVATIVE; BIPHENYL DERIVATIVE; THIAZOLE DERIVATIVE;

EID: 84952870799     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2015.09.007     Document Type: Review
Times cited : (78)

References (46)
  • 1
    • 80052822508 scopus 로고    scopus 로고
    • Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction
    • D.E. Irwin, Z.S. Kopp, B. Agatep, I. Milsom, and P. Abrams Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction BJU Int 108 2011 1132 1138
    • (2011) BJU Int , vol.108 , pp. 1132-1138
    • Irwin, D.E.1    Kopp, Z.S.2    Agatep, B.3    Milsom, I.4    Abrams, P.5
  • 2
    • 33751405577 scopus 로고    scopus 로고
    • A cross-sectional, population-based, multinational study of the prevalence of overactive bladder and lower urinary tract symptoms: Results from the EPIC study
    • I. Milsom, and D.E. Irwin A cross-sectional, population-based, multinational study of the prevalence of overactive bladder and lower urinary tract symptoms: results from the EPIC study Eur Urol 6 Suppl 1 2007 4 9
    • (2007) Eur Urol , vol.6 , pp. 4-9
    • Milsom, I.1    Irwin, D.E.2
  • 3
    • 0141566431 scopus 로고    scopus 로고
    • Prevalence and burden of overactive bladder in the United States
    • W.F. Stewart, J.B. Van Rooyen, G.W. Cundiff, and et al. Prevalence and burden of overactive bladder in the United States World J Urol 20 2003 327 336
    • (2003) World J Urol , vol.20 , pp. 327-336
    • Stewart, W.F.1    Van Rooyen, J.B.2    Cundiff, G.W.3
  • 4
    • 77953818082 scopus 로고    scopus 로고
    • Cardiovascular morbidity, heart rates and use of antimuscarinics in patients with overactive bladder
    • K.E. Andersson, C. Sarawate, K.H. Kahler, E.L. Stanley, and A.S. Kulkarni Cardiovascular morbidity, heart rates and use of antimuscarinics in patients with overactive bladder BJU Int 106 2010 268 274
    • (2010) BJU Int , vol.106 , pp. 268-274
    • Andersson, K.E.1    Sarawate, C.2    Kahler, K.H.3    Stanley, E.L.4    Kulkarni, A.S.5
  • 5
    • 71249129709 scopus 로고    scopus 로고
    • Maximizing the treatment of overactive bladder in the elderly
    • S.A. Macdiarmid Maximizing the treatment of overactive bladder in the elderly Rev Urol 10 2008 6 13
    • (2008) Rev Urol , vol.10 , pp. 6-13
    • Macdiarmid, S.A.1
  • 6
    • 43049114250 scopus 로고    scopus 로고
    • The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: Results from the EPIC study
    • K.S. Coyne, C.C. Sexton, D.E. Irwin, Z.S. Kopp, C.J. Kelleher, and I. Milsom The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study BJU Int 101 2008 1388 1395
    • (2008) BJU Int , vol.101 , pp. 1388-1395
    • Coyne, K.S.1    Sexton, C.C.2    Irwin, D.E.3    Kopp, Z.S.4    Kelleher, C.J.5    Milsom, I.6
  • 7
    • 84867522798 scopus 로고    scopus 로고
    • Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females
    • U. Leone Roberti Maggiore, S. Salvatore, F. Alessandri, and et al. Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females Expert Opin Drug Metab Toxicol 8 2012 1387 1408
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , pp. 1387-1408
    • Leone Roberti Maggiore, U.1    Salvatore, S.2    Alessandri, F.3
  • 8
    • 84886609744 scopus 로고    scopus 로고
    • Cardiovascular effects of antimuscarinic agents in overactive bladder
    • G.M. Rosa, M. Bauckneht, C. Scala, and et al. Cardiovascular effects of antimuscarinic agents in overactive bladder Expert Opin Drug Saf 12 2013 815 827
    • (2013) Expert Opin Drug Saf , vol.12 , pp. 815-827
    • Rosa, G.M.1    Bauckneht, M.2    Scala, C.3
  • 9
    • 32544437708 scopus 로고    scopus 로고
    • Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate
    • M.C. Michel, and W. Vrydag Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate Br J Pharmacol 147 Suppl 2 2006 S88 S119
    • (2006) Br J Pharmacol , vol.147 , pp. S88-S119
    • Michel, M.C.1    Vrydag, W.2
  • 10
  • 11
    • 0036011136 scopus 로고    scopus 로고
    • Beta3-adrenoceptors in human detrusor muscle
    • O. Yamaguchi Beta3-adrenoceptors in human detrusor muscle Urology 59 2002 25 29
    • (2002) Urology , vol.59 , pp. 25-29
    • Yamaguchi, O.1
  • 12
    • 59149087619 scopus 로고    scopus 로고
    • Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man
    • M. Wuest, B. Eichhorn, M.O. Grimm, M.P. Wirth, U. Ravens, and A.J. Kaumann Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man J Pharmacol Exp Ther 328 2009 213 222
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 213-222
    • Wuest, M.1    Eichhorn, B.2    Grimm, M.O.3    Wirth, M.P.4    Ravens, U.5    Kaumann, A.J.6
  • 13
    • 51349085441 scopus 로고    scopus 로고
    • Beta3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current
    • V.A. Skeberdis, V. Gendviliene, D. Zablockaite, and et al. beta3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current J Clin Invest 118 2008 3219 3227
    • (2008) J Clin Invest , vol.118 , pp. 3219-3227
    • Skeberdis, V.A.1    Gendviliene, V.2    Zablockaite, D.3
  • 14
    • 0032707530 scopus 로고    scopus 로고
    • Adrenergic and muscarinic receptors in the human heart
    • O.E. Brodde, and M.C. Michel Adrenergic and muscarinic receptors in the human heart Pharmacol Rev 51 1999 651 690
    • (1999) Pharmacol Rev , vol.51 , pp. 651-690
    • Brodde, O.E.1    Michel, M.C.2
  • 15
    • 84952872130 scopus 로고    scopus 로고
    • Committee for Medicinal Products for Human Use (CHMP) European Medicines Agency Web site
    • Committee for Medicinal Products for Human Use (CHMP). Assessment report: Betmiga. European Medicines Agency Web site. http://www.ema.europa.eu/docs/en-GB/document-library/EPAR-Public-assessment-report/human/002388/WC500137308.pdf.
    • Assessment Report: Betmiga
  • 16
    • 45849142177 scopus 로고    scopus 로고
    • Dose-response effect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health
    • A.B. Grudell, M. Camilleri, K.L. Jensen, and et al. Dose-response effect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health Am J Physiol Gastrointest Liver Physiol 294 2008 G1114 G1119
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , pp. G1114-G1119
    • Grudell, A.B.1    Camilleri, M.2    Jensen, K.L.3
  • 17
    • 33846961446 scopus 로고    scopus 로고
    • Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: A double-blind, placebo-controlled randomized study
    • L.M. Redman, L. de Jonge, X. Fang, and et al. Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: a double-blind, placebo-controlled randomized study J Clin Endocrinol Metab 92 2007 527 531
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 527-531
    • Redman, L.M.1    De Jonge, L.2    Fang, X.3
  • 18
    • 21044449411 scopus 로고    scopus 로고
    • Discovery of a novel and potent human and rat beta3-adrenergic receptor agonist, [3-[(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]ac etic acid
    • H. Harada, Y. Hirokawa, K. Suzuki, and et al. Discovery of a novel and potent human and rat beta3-adrenergic receptor agonist, [3-[(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]ac etic acid Chem Pharm Bull (Tokyo) 53 2005 184 198
    • (2005) Chem Pharm Bull (Tokyo) , vol.53 , pp. 184-198
    • Harada, H.1    Hirokawa, Y.2    Suzuki, K.3
  • 20
    • 84862503635 scopus 로고    scopus 로고
    • 3-adrenoceptor agonist, on bladder function in cynomolgus monkey
    • 3-adrenoceptor agonist, on bladder function in cynomolgus monkey J Pharmacol Exp Ther 342 2012 163 168
    • (2012) J Pharmacol Exp Ther , vol.342 , pp. 163-168
    • Maruyama, I.1    Tatemichi, S.2    Goi, Y.3
  • 21
    • 84857912408 scopus 로고    scopus 로고
    • 3-adrenoceptor agonist, on mammalian detrusor strips
    • e1-7
    • 3-adrenoceptor agonist, on mammalian detrusor strips Urology 79 2012 744.e1-7
    • (2012) Urology , vol.79 , pp. 744
    • Kanie, S.1    Otsuka, A.2    Yoshikawa, S.3
  • 22
    • 0028276038 scopus 로고
    • Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man
    • N.M. Wheeldon, D.G. McDevitt, and B.J. Lipworth Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man Br J Clin Pharmacol 37 1994 363 369
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 363-369
    • Wheeldon, N.M.1    McDevitt, D.G.2    Lipworth, B.J.3
  • 23
    • 61349178824 scopus 로고    scopus 로고
    • The beta3-adrenoceptor as a therapeutic target: Current perspectives
    • M.G. Ursino, V. Vasina, E. Raschi, F. Crema, and F. De Ponti The beta3-adrenoceptor as a therapeutic target: current perspectives Pharmacol Res 59 2009 221 234
    • (2009) Pharmacol Res , vol.59 , pp. 221-234
    • Ursino, M.G.1    Vasina, V.2    Raschi, E.3    Crema, F.4    De Ponti, F.5
  • 24
    • 84879121450 scopus 로고    scopus 로고
    • Mirabegron for the treatment of overactive bladder: A prespecified pooled efficacy analysis and pooled safety analysis of three randomised, double-blind, placebo-controlled, phase III studies
    • V. Nitti, V. Khullar, P. van Kerrebroeck, and et al. Mirabegron for the treatment of overactive bladder: a prespecified pooled efficacy analysis and pooled safety analysis of three randomised, double-blind, placebo-controlled, phase III studies Int J Clin Pract 67 2013 619 632
    • (2013) Int J Clin Pract , vol.67 , pp. 619-632
    • Nitti, V.1    Khullar, V.2    Van Kerrebroeck, P.3
  • 26
    • 84971579967 scopus 로고
    • Collaborative overview of randomised trials of antiplatelet therapy - I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration
    • Collaborative overview of randomised trials of antiplatelet therapy - I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. BMJ 1994;308:81-106.
    • (1994) BMJ , vol.308 , pp. 81-106
  • 27
    • 84886713777 scopus 로고    scopus 로고
    • Advisory committee briefing document April 5 US Food and Drug Administration Web site
    • Advisory committee briefing document. Mirabegron (YM178) for the treatment of overactive bladder, April 5, 2012. US Food and Drug Administration Web site. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/ReproductiveHealthDrugsAdvisoryCommittee/UCM298285.pdf.
    • (2012) Mirabegron (YM178) for the Treatment of Overactive Bladder
  • 28
    • 84939267730 scopus 로고    scopus 로고
    • Results of a randomized, double-blind, parallel-group, placebo- and active-controlled, multicenter study of mirabegron, a beta3-adrenoceptor agonist, in patients with overactive bladder in Asia
    • H.C. Kuo, K.S. Lee, Y. Na, and et al. Results of a randomized, double-blind, parallel-group, placebo- and active-controlled, multicenter study of mirabegron, a beta3-adrenoceptor agonist, in patients with overactive bladder in Asia Neurourol Urodyn 34 2015 685 692
    • (2015) Neurourol Urodyn , vol.34 , pp. 685-692
    • Kuo, H.C.1    Lee, K.S.2    Na, Y.3
  • 29
    • 84880788904 scopus 로고    scopus 로고
    • A phase II dose-ranging study of mirabegron in patients with overactive bladder
    • C.R. Chapple, V. Dvorak, P. Radziszewski, and et al. A phase II dose-ranging study of mirabegron in patients with overactive bladder Int Urogynecol J 24 2013 1447 1458
    • (2013) Int Urogynecol J , vol.24 , pp. 1447-1458
    • Chapple, C.R.1    Dvorak, V.2    Radziszewski, P.3
  • 30
    • 84902256286 scopus 로고    scopus 로고
    • Phase III, randomised, double-blind, placebo-controlled study of the beta3-adrenoceptor agonist mirabegron, 50 mg once daily, in Japanese patients with overactive bladder
    • O. Yamaguchi, E. Marui, H. Kakizaki, and et al. Phase III, randomised, double-blind, placebo-controlled study of the beta3-adrenoceptor agonist mirabegron, 50 mg once daily, in Japanese patients with overactive bladder BJU Int 113 2014 951 960
    • (2014) BJU Int , vol.113 , pp. 951-960
    • Yamaguchi, O.1    Marui, E.2    Kakizaki, H.3
  • 31
    • 84886394357 scopus 로고    scopus 로고
    • A proof-of-concept study: Mirabegron, a new therapy for overactive bladder
    • C.R. Chapple, G. Amarenco, M.A. Lopez Aramburu, and et al. A proof-of-concept study: Mirabegron, a new therapy for overactive bladder Neurourol Urodyn 32 2013 1116 1122
    • (2013) Neurourol Urodyn , vol.32 , pp. 1116-1122
    • Chapple, C.R.1    Amarenco, G.2    Lopez Aramburu, M.A.3
  • 32
    • 84869491480 scopus 로고    scopus 로고
    • Proarrhythmic safety of repeat doses of mirabegron in healthy subjects: A randomized, double-blind, placebo-, and active-controlled thorough QT study
    • M. Malik, E.M. van Gelderen, J.H. Lee, and et al. Proarrhythmic safety of repeat doses of mirabegron in healthy subjects: a randomized, double-blind, placebo-, and active-controlled thorough QT study Clin Pharmacol Ther 92 2012 696 706
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 696-706
    • Malik, M.1    Van Gelderen, E.M.2    Lee, J.H.3
  • 33
  • 34
    • 84867344252 scopus 로고    scopus 로고
    • Pharmacokinetic properties of mirabegron, a beta3-adrenoceptor agonist: Results from two phase I, randomized, multiple-dose studies in healthy young and elderly men and women
    • W. Krauwinkel, J. van Dijk, M. Schaddelee, and et al. Pharmacokinetic properties of mirabegron, a beta3-adrenoceptor agonist: results from two phase I, randomized, multiple-dose studies in healthy young and elderly men and women Clin Ther 34 2012 2144 2160
    • (2012) Clin Ther , vol.34 , pp. 2144-2160
    • Krauwinkel, W.1    Van Dijk, J.2    Schaddelee, M.3
  • 35
    • 84891860819 scopus 로고    scopus 로고
    • Pharmacokinetics of mirabegron, a beta3-adrenoceptor agonist for treatment of overactive bladder, in healthy Japanese male subjects: Results from single- and multiple-dose studies
    • H. Iitsuka, T. Tokuno, Y. Amada, and et al. Pharmacokinetics of mirabegron, a beta3-adrenoceptor agonist for treatment of overactive bladder, in healthy Japanese male subjects: results from single- and multiple-dose studies Clin Drug Investig 34 2014 27 35
    • (2014) Clin Drug Investig , vol.34 , pp. 27-35
    • Iitsuka, H.1    Tokuno, T.2    Amada, Y.3
  • 36
    • 84905826940 scopus 로고    scopus 로고
    • Absence of clinically relevant cardiovascular interaction upon add-on of mirabegron or tamsulosin to an established tamsulosin or mirabegron treatment in healthy middle-aged to elderly men
    • M. van Gelderen, R. Tretter, J. Meijer, and et al. Absence of clinically relevant cardiovascular interaction upon add-on of mirabegron or tamsulosin to an established tamsulosin or mirabegron treatment in healthy middle-aged to elderly men Int J Clin Pharmacol Ther 52 2014 693 701
    • (2014) Int J Clin Pharmacol Ther , vol.52 , pp. 693-701
    • Van Gelderen, M.1    Tretter, R.2    Meijer, J.3
  • 37
    • 84867064355 scopus 로고    scopus 로고
    • A multicenter, double-blind, randomized, placebo-controlled trial of the beta3-adrenoceptor agonist solabegron for overactive bladder
    • E.H. Ohlstein, A. von Keitz, and M.C. Michel A multicenter, double-blind, randomized, placebo-controlled trial of the beta3-adrenoceptor agonist solabegron for overactive bladder Eur Urol 62 2012 834 840
    • (2012) Eur Urol , vol.62 , pp. 834-840
    • Ohlstein, E.H.1    Von Keitz, A.2    Michel, M.C.3
  • 38
    • 27244456179 scopus 로고    scopus 로고
    • HHS. International Conference on Harmonisation; Guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs; Availability
    • Food Drug Administration HHS. International Conference on Harmonisation; guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs; availability Notice. Fed Regist 70 2005 61134 61135
    • (2005) Notice. Fed Regist , vol.70 , pp. 61134-61135
  • 39
    • 80055060619 scopus 로고    scopus 로고
    • Beta-3 adrenoceptors as new therapeutic targets for cardiovascular pathologies
    • C. Gauthier, B. Rozec, B. Manoury, and J.L. Balligand Beta-3 adrenoceptors as new therapeutic targets for cardiovascular pathologies Curr Heart Fail Rep 8 2011 184 192
    • (2011) Curr Heart Fail Rep , vol.8 , pp. 184-192
    • Gauthier, C.1    Rozec, B.2    Manoury, B.3    Balligand, J.L.4
  • 40
    • 84952876115 scopus 로고    scopus 로고
    • Background document for meeting of Advisory Committee for Reproductive Health Drugs, April 5, 2012. NDA 202611 Mirabegron Tablets US Food and Drug Administration Web site
    • Background document for meeting of Advisory Committee for Reproductive Health Drugs, April 5, 2012. NDA 202611 Mirabegron Tablets. Astellas Pharma Global Development. US Food and Drug Administration Web site. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/ReproductiveHealthDrugsAdvisoryCommittee/UCM298641.pdf.
    • Astellas Pharma Global Development
  • 41
    • 84871925684 scopus 로고    scopus 로고
    • 3-adrenoceptor agonist, in patients with overactive bladder: Results from a randomised European-Australian phase 3 trial
    • 3-adrenoceptor agonist, in patients with overactive bladder: results from a randomised European-Australian phase 3 trial Eur Urol 63 2013 283 295
    • (2013) Eur Urol , vol.63 , pp. 283-295
    • Khullar, V.1    Amarenco, G.2    Angulo, J.C.3
  • 42
    • 84875953225 scopus 로고    scopus 로고
    • Results of a randomized phase III trial of mirabegron in patients with overactive bladder
    • V.W. Nitti, S. Auerbach, N. Martin, A. Calhoun, M. Lee, and S. Herschorn Results of a randomized phase III trial of mirabegron in patients with overactive bladder J Urol 189 2013 1388 1395
    • (2013) J Urol , vol.189 , pp. 1388-1395
    • Nitti, V.W.1    Auerbach, S.2    Martin, N.3    Calhoun, A.4    Lee, M.5    Herschorn, S.6
  • 44
    • 84897053329 scopus 로고    scopus 로고
    • The effect of mirabegron, a potent and selective beta3-adrenoceptor agonist, on the pharmacokinetics of CYP2D6 substrates desipramine and metoprolol
    • W. Krauwinkel, J. Dickinson, M. Schaddelee, and et al. The effect of mirabegron, a potent and selective beta3-adrenoceptor agonist, on the pharmacokinetics of CYP2D6 substrates desipramine and metoprolol Eur J Drug Metab Pharmacokinet 39 2014 43 52
    • (2014) Eur J Drug Metab Pharmacokinet , vol.39 , pp. 43-52
    • Krauwinkel, W.1    Dickinson, J.2    Schaddelee, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.