Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells

Toxicology

Volumn 339, Issue , 2016, Pages 73-86

  Poussin, Carine ^a   Laurent, Alexandra ^a   Peitsch, Manuel C ^a   Hoeng, Julia ^a   De Leon, Hector ^a  

^a PHILIP MORRIS PRODUCTS S A   (Switzerland)

Author keywords

Adhesion; Atherosclerosis; Cigarette; Endothelial cell; Modified risk tobacco product; Monocyte

Indexed keywords

AQUEOUS SOLUTION; ARTICLE; CARDIOVASCULAR RISK; CELL ADHESION; CORONARY ARTERY; ENDOTHELIUM CELL; HEATING; HUMAN; HUMAN CELL; IN VITRO STUDY; MONOCYTE; PRIORITY JOURNAL; SYSTEMS BIOLOGY; SYSTEMS TOXICOLOGY; TOBACCO; ADVERSE EFFECTS; AEROSOL; ANALYSIS; ATHEROSCLEROSIS; CHEMICALLY INDUCED; CHEMISTRY; CORONARY BLOOD VESSEL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; HEAT; PATHOLOGY; PROTEIN CARBONYLATION; SMOKE; TOXICITY; VASCULAR ENDOTHELIUM;

AEROSOL; CYTOKINE; NICOTINE; SMOKE;

AEROSOLS; ATHEROSCLEROSIS; CELL ADHESION; CORONARY VESSELS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HOT TEMPERATURE; HUMANS; IN VITRO TECHNIQUES; MONOCYTES; NICOTINE; PROTEIN CARBONYLATION; SMOKE; TOBACCO;

EID: 84952802317     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2015.11.007     Document Type: Article

References (39)

1. Ackermann M., Strimmer K. A general modular framework for gene set enrichment analysis. BMC Bioinf. 2009, 10:47.
2. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B 1995, 57:289-300.
3. Boue S., Talikka M., Westra J.W., Hayes W., Di Fabio A., Park J., Schlage W.K., Sewer A., Fields B., Ansari S., Martin F., Veljkovic E., Kenney R., Peitsch M.C., Hoeng J. Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems. Database 2015, 2015:bav030.
4. Cumming G., Fidler F., Vaux D.L. Error bars in experimental biology. J. Cell Biol. 2007, 177:7-11.
5. Demirjian L., Abboud R.T., Li H., Duronio V. Acute effect of cigarette smoke on TNF-alpha release by macrophages mediated through the erk1/2 pathway. Biochim. Biophys. Acta 2006, 1762:592-597.
6. Favero G., Paganelli C., Buffoli B., Rodella L.F., Rezzani R. Endothelium and its alterations in cardiovascular diseases: life style intervention. BioMed Res. Int. 2014, 2014(801896).
7. Food and Drug Administration, 2012. Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke; Established List. U.S. Department of Health and Human Services, Food and Drug Administration, Rockville, MD: Center for Tobacco Products. In Federal Register 77, 20034-20037.
8. Food and Drug Administration, 2012. Modified Risk Tobacco Product Applications: Draft Guidance for Industry.
9. Haussmann H.J. Use of hazard indices for a theoretical evaluation of cigarette smoke composition. Chem. Res. Toxicol. 2012, 25:794-810.
10. Hermida L., Poussin C., Stadler M.B., Gubian S., Sewer A., Gaidatzis D., Hotz H.R., Martin F., Belcastro V., Cano S., Peitsch M.C., Hoeng J. Confero: an integrated contrast data and gene set platform for computational analysis and biological interpretation of omics data. BMC Genomics 2013, 14:514.
11. Hoeng J., Talikka M., Martin F., Sewer A., Yang X., Iskandar A., Schlage W.K., Peitsch M.C. Case study: the role of mechanistic network models in systems toxicology. Drug Discov. Today 2014, 19:183-192.
12. Kalra V.K., Ying Y., Deemer K., Natarajan R., Nadler J.L., Coates T.D. Mechanism of cigarette smoke condensate induced adhesion of human monocytes to cultured endothelial cells. J. Cell. Physiol. 1994, 160:154-162.
13. Kogel U., Schlage W.K., Martin F., Xiang Y., Ansari S., Leroy P., Vanscheeuwijck P., Gebel S., Buettner A., Wyss C., Esposito M., Hoeng J., Peitsch M.C. A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes. Food Chem. Toxicol. 2014, 68:204-217.
14. Lehr H.A. Adhesion-promoting effects of cigarette smoke on leukocytes and endothelial cells. Ann. N. Y. Acad. Sci. 1993, 686:112-118. discussion 118-119.
15. Martin F., Sewer A., Talikka M., Xiang Y., Hoeng J., Peitsch M.C. Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models. BMC Bioinf. 2014, 15:238.
16. Messner B., Bernhard D. Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis. Arterioscler. Thromb. Vasc. Biol. 2014, 34:509-515.
17. Perfetti T.A., Rodgman A. The complexity of tobacco and tobacco smoke. Beitrage zur Tabakforschung International 2011, 24:215-232.
18. Phillips B., Veljkovic E., Peck M.J., Buettner A., Elamin A., Guedj E., Vuillaume G., Ivanov N.V., Martin F., Boue S., Schlage W.K., Schneider T., Titz B., Talikka M., Vanscheeuwijck P., Hoeng J., Peitsch M.C. A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product. Food Chemical Toxicol. 2015, 80:328-345.
19. Phillips B., Veljkovic E., Boue S., Schlage W.K., Vuillaume G., Martin F., Titz B., Leroy P., Buettner A., Elamin A., Oviedo A., Cabanski M., Guedj E., Schneider T., Talikka M., Ivanov N.V., Vanscheeuwijck P., Peitsch M.C., Hoeng J. An 8-month systems toxicology inhalation/cessation study in apoe-/- mice to investigate cardiovascular and respiratory exposure effects of a candidate modified risk tobacco product, THS 2.2, compared with conventional cigarettes. Toxicol. Sci. 2015, 10.1093/toxsci/kfv243.
20. Poussin C., Gallitz I., Schlage W.K., Steffen Y., Stolle K., Lebrun S., Hoeng J., Peitsch M.C., Lietz M. Mechanism of an indirect effect of aqueous cigarette smoke extract on the adhesion of monocytic cells to endothelial cells in an in vitro assay revealed by transcriptomics analysis. Toxicol. in Vitro 2014, 28:896-908.
21. Poussin C., Laurent A., Peitsch M.C., Hoeng J., De Leon H. Systems biology reveals cigarette smoke-induced concentration-dependent direct and indirect mechanisms that promote monocyte-endothelial cell adhesion. Toxicol. Sci. 2015, 147:370-385.
22. Rodgman A., Perfetti T.A. The Chemical Components of Tobacco and Tobacco Smoke 2013, CRC Press. Second ed.
23. sbv IMPROVER project team, Ansari S., Binder J., Boue S., Di Fabio A., Hayes W., Hoeng J., Iskandar A., Kleiman R., Norel R., O'Neel B., Peitsch M.C., Poussin C., Pratt D., Rhrissorrakrai K., Schlage W.K., Stolovitzky G., Talikka M. On Crowd-verification of Biological Networks. Bioinfor. Biol. Insights 2013, 7:307-325.
24. Scholz D., Devaux B., Hirche A., Potzsch B., Kropp B., Schaper W., Schaper J. Expression of adhesion molecules is specific and time-dependent in cytokine-stimulated endothelial cells in culture. Cell Tissue Res. 1996, 284:415-423.
25. Schorp M.K., Tricker A.R., Dempsey R. Reduced exposure evaluation of an Electrically Heated Cigarette Smoking System. Part 1: non-clinical and clinical insights. Regul. Toxicol. Pharmacol. 2012, 64:S1-10.
26. Smyth G.K. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 2004, 3.
27. Stocker C.J., Sugars K.L., Harari O.A., Landis R.C., Morley B.J., Haskard D.O. TNF-alpha, IL-4, and IFN-gamma regulate differential expression of P- and E-selectin expression by porcine aortic endothelial cells. J. Immunol. 2000, 164:3309-3315.
28. Su Y., Han W., Giraldo C., De Li Y., Block E.R. Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells. Am. J. Respir. Cell Mol. Biol. 1998, 19:819-825.
29. Thomson T.M., Sewer A., Martin F., Belcastro V., Frushour B.P., Gebel S., Park J., Schlage W.K., Talikka M., Vasilyev D.M., Westra J.W., Hoeng J., Peitsch M.C. Quantitative assessment of biological impact using transcriptomic data and mechanistic network models. Toxicol. Appl. Pharmacol. 2013, 272:863-878.
30. Wang Y., Wang L., Ai X., Zhao J., Hao X., Lu Y., Qiao Z. Nicotine could augment adhesion molecule expression in human endothelial cells through macrophages secreting TNF-alpha, IL-1beta. Int. Immunopharmacol. 2004, 4:1675-1686.
31. Werley M.S., Freelin S.A., Wrenn S.E., Gerstenberg B., Roemer E., Schramke H., Van Miert E., Vanscheeuwijck P., Weber S., Coggins C.R. Smoke chemistry, in vitro and in vivo toxicology evaluations of the electrically heated cigarette smoking system series K. Regul. Toxicol. Pharmacol. 2008, 52:122-139.
32. Winkelmann B.R., von Holt K., Unverdorben M. Smoking and atherosclerotic cardiovascular disease: part I: atherosclerotic disease process. Biomarkers Med. 2009, 3:411-428.
33. Wright W.R., Parzych K., Crawford D., Mein C., Mitchell J.A., Paul-Clark M.J. Inflammatory transcriptome profiling of human monocytes exposed acutely to cigarette smoke. PLoS One 2012, 7:e30120.
34. Wu Z., Irizarry R.A., Gentleman R., Murillo F.M., Spencer F. A model based background adjustment for oligonucleotide expression arrays. Working Paper 1 2004, Johns Hopkins University, Dept. of Biostatistics.
35. Yanbaeva D.G., Dentener M.A., Creutzberg E.C., Wesseling G., Wouters E.F. Systemic effects of smoking. Chest 2007, 131:1557-1566.
36. Zhang X., Wang L., Zhang H., Guo D., Zhao J., Qiao Z., Qiao J. The effects of cigarette smoke extract on the endothelial production of soluble intercellular adhesion molecule-1 are mediated through macrophages, possibly by inducing TNF-alpha release. Methods Find. Exp. Clin. Pharmacol. 2002, 24:261-265.
37. van Leeuwen D.M., Gottschalk R.W., van Herwijnen M.H., Moonen E.J., Kleinjans J.C., van Delft J.H. Differential gene expression in human peripheral blood mononuclear cells induced by cigarette smoke and its constituents. Toxicol. Sci. 2005, 86:200-210.
38. van der Toorn M., Frentzel S., De Leon H., Goedertier D., Peitsch M.C., Hoeng J. Aerosol from a candidate modified risk tobacco product has reduced effects on chemotaxis and transendothelial migration compared to combustion of conventional cigarettes. Food Chem. Toxicol. 2015, 86:81-87.
39. van der Toorn M., Frentzel S., Goedertier D., Peitsch M., Hoeng J., De Leon H. A prototypic modified risk tobacco product exhibits reduced effects on chemotaxis and transendothelial migration of monocytes compared with a reference cigarette. Food Chem. Toxicol. 2015, 80:277-286.