Developmental toxicity studies with 6 forms of titanium dioxide test materials (3 pigment-different grade & 3 nanoscale) demonstrate an absence of effects in orally-exposed rats

Regulatory Toxicology and Pharmacology

Volumn 73, Issue 3, 2015, Pages 887-896

  Warheit, D B ^a   Boatman, R ^b   Brown, S C ^a  

^a CHEMOURS COMPANY   (United States)

^b Boatman Toxicology Consulting LLC   (United States)

Author keywords

Developmental toxicity; Nanoparticle; Nanoscale TiO2 particles; OECD 414 test guidelines; Particle; Particle characterization; Particle size distribution; Pigment grade TiO2 particles; Prenatal developmental toxicity study; Titanium dioxide

Indexed keywords

TITANIUM DIOXIDE; NANOPARTICLE; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; EMBRYOFETAL SURVIVAL; EXPOSURE; FEMALE; FETUS; FETUS MALFORMATION; FETUS WEIGHT; FOOD INTAKE; MALE; MATERNAL BODY WEIGHT; NONHUMAN; ORAL EXPOSURE; PHYSICAL CHEMISTRY; PRENATAL EXPOSURE; PRENATAL GROWTH; PRIORITY JOURNAL; RAT; SURVIVAL; TOXICITY TESTING; WEIGHT GAIN; ANIMAL; CHEMISTRY; DRUG EFFECTS; FETUS DEVELOPMENT; GESTATIONAL AGE; NANOTECHNOLOGY; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORAL DRUG ADMINISTRATION; PREGNANCY; PROCEDURES; RISK ASSESSMENT; SPRAGUE DAWLEY RAT; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; FEMALE; FETAL DEVELOPMENT; FETUS; GESTATIONAL AGE; MALE; NANOPARTICLES; NANOTECHNOLOGY; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PREGNANCY; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RISK ASSESSMENT; TITANIUM; TOXICITY TESTS;

EID: 84952715050     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2015.09.032     Document Type: Article

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