Role of thermo TRPA1 and TRPV1 channels in heat, cold, and mechanical nociception of rats

Behavioural Pharmacology

Volumn 27, Issue 1, 2016, Pages 29-36

  Nozadze, Ivliane ^a   Tsiklauri, Nana ^a   Gurtskaia, Gulnazi ^a   Tsagareli, Merab G ^a  

^a Georgia   (Georgia)

Author keywords

Capsaicin; Cold pain; Heat pain; Hyperalgesia; Mechanical allodynia; Mustard oil; Rat; Thermal preference

Indexed keywords

ALLYL ISOTHIOCYANATE; CAPSAICIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; VANILLOID RECEPTOR 1; AGENTS ACTING ON THE PERIPHERAL NERVOUS AND NEUROMUSCULAR SYSTEMS; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPA1 PROTEIN, RAT; TRPV1 PROTEIN, RAT; VANILLOID RECEPTOR; VEGETABLE OIL;

ADULT; ANIMAL EXPERIMENT; ARTICLE; COLD PLATE TEST; COLD SENSITIVITY; CONTROLLED STUDY; HEAT SENSITIVITY; MALE; MECHANICAL NOCICEPTION; NOCICEPTION; NONHUMAN; PAIN RECEPTOR; RAT; TEMPERATURE; THERMAL PREFERENCE TEST; THERMAL STIMULUS TEST; THERMORECEPTOR; AGONISTS; ANIMAL; COLD; DOSE RESPONSE; HEAT; METABOLISM; MUSTARD; NOCICEPTIVE PAIN; PHYSIOLOGY; TOUCH; WISTAR RAT;

ANIMALS; CAPSAICIN; COLD TEMPERATURE; DOSE-RESPONSE RELATIONSHIP, DRUG; HOT TEMPERATURE; MALE; MUSTARD PLANT; NOCICEPTION; NOCICEPTIVE PAIN; PLANT OILS; RATS, WISTAR; SENSORY SYSTEM AGENTS; TOUCH; TRPC CATION CHANNELS; TRPV CATION CHANNELS;

EID: 84952663529     PISSN: 09558810     EISSN: 14735849     Source Type: Journal    
DOI: 10.1097/FBP.0000000000000176     Document Type: Article

References (54)

1. Albin KC, Carstens MI, Carstens E (2008). Modulation of oral heat and cold pain by irritant chemicals. Chem Senses 33:3-15.
2. Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, et al. (2004). Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41:849-857.
3. Basbaum AI, Bautista DM, Scherrer G, Julius D (2009). Cellular and molecular mechanisms of pain. Cell 139:267-284.
4. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, et al. (2006). TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124:1269-1282.
5. Belmonte C, Viana F (2008). Molecular and cellular limits to somatosensory specificity. Mol Pain 4:14.
6. Bessac BF, Jordt SE (2008). Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda) 23:360-370.
7. Bráz JM, Basbaum AI (2010). Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli. Pain 150:290-301.
8. Carstens E, Albin KC, Simons CT, Carstens MI (2007). Time course of self-desensitization of oral irritation by nicotine and capsaicin. Chem Senses 32:811-816.
9. Carstens C, Klein A, Iodi Carstens M, Tsagareli MG, Tsiklauri N, Gurtskaia G, Abzianidze E (2010). Effects of thermosensitive transient receptor potential (TRP) channel agonists on the neural coding of touch, temperature and pain sensation. Proceedings of the 9th "Gagra Talks", International Conference Fundamental Problems of Neuroscience; 13-16 October 2010 Tbilisi.
10. Caterina MJ (2007). Transient receptor potential ion channels as participants in thermosensation and thermoregulation. Am J Physiol Regul Integr Comp Physiol 292:R64-R76.
11. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, et al. (2000). Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306-313.
12. Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, et al. (2001). Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns (4, 5) P2-mediated inhibition. Nature 411:957-962.
13. Davis JB, Gray J, Gunthorpe MJ, Hatcher J P, Davey PT, Overend P, et al. (2000). Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405:183-187.
14. De Felice M, Eyde N, Dodick D, Dussor GO, Ossipov MH, Fields HL, Porreca F (2013). Capturing the aversive state of cephalic pain preclinically. Ann Neurol 74:257-265.
15. Eid SR, Crown ED, Moore EL, Liang HA, Choong KC, Dima S, et al. (2008). HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain 4:48.
16. Fischer MJ, Balasuriya D, Jeggle P, Goetze TA, McNaughton PA, Reeh PW, Edwardson JM (2014). Direct evidence for functional TRPV1/TRPA1 heteromers. Pflugers Arch 466:2229-2241.
17. Gerhold KA, Bautista DM (2009). Molecular and cellular mechanisms of trigeminal chemosensation. Ann N YAcad Sci 1170:184-189.
18. Hoffmann T, Kistner K, Miermeister F, Winkelmann R, Wittmann J, Fischer MJ, et al. (2013). TRPA1 and TRPV1 are differentially involved in heat nociception of mice. Eur J Pain 17:1472-1482.
19. Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, et al. (2004). Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427:260-265.
20. Karashima Y, Talavera K, Everaerts W, Janssens A, Kwan KY, Vennekens R, et al. (2009). TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci USA 106:1273-1278.
21. Kerstein PC, Del Camino D, Moran MM, Stucky CL (2009). Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol Pain 5:19.
22. Klein AH, Sawyer CM, Carstens MI, Tsagareli MG, Tsiklauri N, Carstens E (2010). Topical application of L-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats. Behav Brain Res 212:179-186.
23. Kobayashi K, Fukuoka T, Obata K, Yamanaka H, Dai Y, Tokunaga A, Noguchi K (2005). Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with A-delta/C-fibers and colocalization with TRK receptors. J Comp Neurol 493:596-606.
24. Koltzenburg M, Lundberg LE, Torebjörk HE (1992). Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain 51:207-219.
25. Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang DS, Woolf CJ, Corey DP (2006). TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 50:277-289.
26. LaMotte RH, Shain CN, Simone DA, Tsai EF (1991). Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. J Neurophysiol 66:190-211.
27. LaMotte RH, Lundberg LE, Torebjörk HE (1992). Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. J Physiol 448:749-764.
28. Macpherson LJ, Geierstanger BH, Viswanath V, Bandell M, Eid SR, Hwang S, Patapoutian A (2005). The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol 15:929-934.
29. Merrill AW, Cuellar JM, Judd JH, Carstens MI, Carstens E (2008). Effects of TRPA1 agonists mustard oil and cinnamaldehyde on lumbar spinal widedynamic range neuronal responses to innocuous and noxious cutaneous stimuli in rats. J Neurophysiol 99:415-425.
30. Mishra SK, Tisel SM, Orestes P, Bhangoo SK, Hoon MA (2011). TRPV1-lineage neurons are required for thermal sensation. EMBO J 30:582-593.
31. Moran MM, McAlexander MA, Bíró T, Szallasi A (2011). Transient receptor potential channels as therapeutic targets. Nat Rev Drug Discov 10:601-620.
32. Namer B, Seifert F, Handwerker HO, Maihöfner C (2005). TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. Neuroreport 16:955-959.
33. Navratilova E, Xie JY, Okun A, Qu C, Eyde N, Ci S, et al. (2012). Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. Proc Natl Acad Sci USA 109:20709-20713.
34. Navratilova E, Xie JY, King T, Porreca F (2013). Evaluation of reward from pain relief. Ann NYAcad Sci 1282:1-11.
35. O'Neill J, Brock C, Olesen AE, Andresen T, Nilsson M, Dickenson AH (2012). Unravelling the mystery of capsaicin: a tool to understand and treat pain. Pharmacol Rev 64:939-971.
36. Pertovaara A, Koivisto A (2011). TRPA1 ion channel in the spinal dorsal horn as a therapeutic target in central pain hypersensitivity and cutaneous neurogenic inflammation. Eur J Pharmacol 666:1-4.
37. Sawyer CM, Carstens MI, Carstens E (2009). Mustard oil enhances spinal neu-ronal responses to noxious heat but not cooling. Neurosci Lett 461:271-274.
38. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, et al. (2003). ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112:819-829.
39. Spahn V, Stein C, Zöllner C (2014). Modulation of transient receptor vanilloid 1 activity by transient receptor potential ankyrin 1. Mol Pharmacol 85:335-344.
40. Sugiura T, Tominaga M, Katsuya H, Mizumura K (2002). Bradykinin lowers the threshold temperature for heat activation of vanilloid receptor 1. J Neurophysiol 88:544-548.
41. Taylor NAS (2014). Human heat adaptation. Compr Physiol 4:325-365.
42. Tipton MJ, Pandolf KB, Sawka MN, Werner J, Taylor NAS (2008). Physiological adaptation to hot and cold environments. In: Taylor NAS, Groeller H, editors. Physiological bases of human performance during work and exercise. Edinburgh: Churchill Livingstone Elsevier. pp. 379-400.
43. Tominaga M (2009). Thermal sensation (cold and heat) through thermosensitive TRP channel activation. In: Basbaum AI, Bushnell MC, editors. Science of pain. San Diego: Elsevier. pp. 127-132.
44. Torebjörk HE, Lundberg LE, LaMotte RH (1992). Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol 448:765-780.
45. Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, et al. (2007). 4-hydro-xynonenal, an endogenous aldehyde, causes pain and neu-rogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci USA 104:3519-13524.
46. Tsagareli MG (2011). Behavioral testing of the effects of thermosensitive TRP channel agonists on touch, temperature and pain sensations. Neurophysiol 43:309-320.
47. Tsagareli MG (2013). Transient receptor potential ion channels as promising therapeutic targets: an overview. In: Atta-ur-Rahman, MI Choudhary, editors. Frontiers in CNS Drug Discovery. London: Bentham Press; 2:118-145.
48. Tsagareli MG, Tsiklauri N, Zanotto KL, Carstens MI, Klein AH, Sawyer CM, et al. (2010). Behavioral evidence of thermal hyperalgesia and mechanical allodynia induced by intradermal cinnamaldehyde in rats. Neurosci Lett 473:233-236.
49. Wei H, Koivisto A, Saarnilehto M, Chapman H, Kuokkanen K, Hao B, et al. (2011). Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat. Pain 152:582-591.
50. Wei H, Karimaa M, Korjamo T, Koivisto A, Pertovaara A (2012). Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain. Anesthesiology 117:137-148.
51. Zanotto KL, Iodi Carstens M, Carstens E (2008). Cross-desensitization of responses of rat trigeminal subnucleus caudalis neurons to cinnamaldehyde and menthol. Neurosci Lett 430:29-33.
52. Zheng J (2013). Molecular mechanism of TRP channels. Compr Physiol 3:221-242.
53. Zimmermann M (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109-110.
54. Zimmermann K, Leffler A, Fischer MM, Messlinger K, Nau C, Reeh PW (2005). The TRPV1/2/3 activator 2-aminoethoxydiphenyl borate sensitizes native nociceptive neurons to heat in wildtype but not TRPV1 deficient mice. Neuroscience 135:277-1284.