Phenotypic profile of expanded NK cells in chronic lymphoproliferative disorders: A surrogate marker for NK-cell clonality

Oncotarget

Volumn 6, Issue 40, 2015, Pages 42938-42951

  Bárcena, Paloma ^a   Jara Acevedo, María ^a   Tabernero, María Dolores ^b   López, Antonio ^a   Sánchez, María Luz ^a   García Montero, Andrés C ^a   Muñoz García, Noemí ^a   Vidriales, María Belén ^b   Paiva, Artur ^c   Lecrevisse, Quentin ^a   Lima, Margarida ^d   Langerak, Anton W ^e   Böttcher, Sebastian ^f   van Dongen, Jacques J M ^e   Orfao, Alberto ^a   Almeida, Julia ^a  

^a CSIC   (Spain)

^b HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^d HOSPITAL DE SANTO ANTÓNIO   (Portugal)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Clonality; CLPD NK; Immunophenotype; Natural killer cells; NK cells

Indexed keywords

ANDROGEN RECEPTOR; CD11B ANTIGEN; CD161 ANTIGEN; CD2 ANTIGEN; CD38 ANTIGEN; CD7 ANTIGEN; CD94 ANTIGEN; HLA DR ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL1; STAT3 PROTEIN; STAT5B PROTEIN; AR PROTEIN, HUMAN; BIOLOGICAL MARKER;

ADULT; ARTICLE; BLOOD; CLINICAL FEATURE; CLONAL VARIATION; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE MARKER; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOPHENOTYPING; LABORATORY TEST; LYMPHOCYTE COUNT; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; NATURAL KILLER CELL; PHENOTYPE; POLYCLONAL ACTIVATION; AGED; CELL CLONE; CHRONIC DISEASE; CLUSTER ANALYSIS; LYMPHOPROLIFERATIVE DISORDERS; MIDDLE AGED; PATHOLOGY; PROCEDURES; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS; CHRONIC DISEASE; CLONE CELLS; CLUSTER ANALYSIS; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; KILLER CELLS, NATURAL; LYMPHOPROLIFERATIVE DISORDERS; MIDDLE AGED; PHENOTYPE; RECEPTORS, ANDROGEN;

EID: 84952361234     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5480     Document Type: Article

References (51)

1. Loughran TP Jr. Clonal diseases of large granular lymphocytes. Blood. 1993; 82:1-14.
2. Lamy T, Loughran TP Jr. Current concepts: large granular lymphocyte leukemia. Blood Reviews. 1999; 13:230-240.
3. Semenzato G, Marino F, Zambello R. State of the art in natural killer cell malignancies. International Journal of Laboratory Hematology. 2012; 34:117-128.
4. Mori KL, Egashira M, Oshimi K. Differentiation stage of natural killer cell-lineage lymphoproliferative disorders based on phenotypic analysis. British Journal of Haematology. 2001; 115:225-228.
5. Lima M, Almeida J, Teixeira MA, Santos AH, Queirós ML, Fonseca S, Moura J, Gonçalves M, Orfao A, Pinto Ribeiro AC. Reactive phenotypes after acute and chronic NK-cell activation. Journal of Biological Regulators and Homeostatic Agent. 2004; 18:331-334.
6. Oshimi K, Yamada O, Kaneko T, Nishinarita S, Lizuka Y, Urabe A, Inamori T, Asano S, Takahashi S, Hattori M. Laboratory findings and clinical courses of 33 patients with granular lymphocyte-proliferative disorders. Leukemia. 1993; 7:782-788.
7. Tefferi A, Li CY, Witzig TE, Dhodapkar MV, Okuno SH, Phyliky RL. Chronic natural killer cell lymphocytosis: a descriptive clinical study. Blood. 1994; 84:2721-2725.
8. Semenzato G, Zambello R, Starkebaum G, Oshimi K, Loughran TP Jr. The lymphoproliferative disease of granular lymphocytes: updated criteria for diagnosis. Blood. 1997; 89:256-260.
9. Oshimi K. Progress in understanding and managing natural killer-cell malignancies. Brithish Journal of Haematology. 2007; 139:532-544.
10. Zambello R, Semenzato G. Large granular lymphocyte disorders: new etiopathogenetic clues as a rationale for innovative therapeutic approaches. Haematologica. 2009; 94:1341-1345.
11. Villamor N, Morice WG, Chan WC, Fourcar K. Chronic lymphoproliferative disorders of NK cells. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Swerdlow SH, Harris NL, Jaffe EJ, Pirelli SA, Stein H, Thiele J, Vardiman J. (4th edn)International Agency for Research of Cancer (IARC)Lyon, France: 2008;:274-275.
12. Lim MS, de Leval L, Quintanilla-Martinez L. Commentary on the 2008 WHO classification of mature T-and NK-cell neoplasms. Journal of Hematopathology. 2009; 2:65-73.
13. Tien HF, Su IJ, Tang JL, Liu MC, Lee FY, Chen YC, Chuang SM. Clonal chromosomal abnormalities as direct evidence for clonality in nasal T/natural killer cell lymphomas. British Journal of Haematology. 1997; 97:621-625.
14. Wong KF, Chan JK, Kwong YL. Identification of del(6)(q21q25) as a recurring chromosomal abnormality in putative NK cell lymphoma/leukaemia. British Journal of Haematology. 1997; 98:922-926.
15. Oshimi K. Leukemia and lymphoma of natural killer lineage cells. International Journal of Hematology. 2003; 78:18-23.
16. Kawa-Ha K, Ishihara S, Ninomiya T, Yumura-Yagi K, Hara J, Murayama F, Tawa A, Hirai K. CD3-negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr viral DNA. Journal of Clinical Investigation. 1989; 84:51-55.
17. Satoh M, Oyama N, Akiba H, Ohtsuka M, Iwatsuki K, Kaneko F. Hypersensitivity to mosquito bites with natural-killer cell lymphocytosis: the possible implication of Epstein-Barr virus reactivation. European Journal of Dermatology. 2002; 12:381-384.
18. Siu LL, Chan JK, Kwong YL. Natural killer cell malignancies: clinicopathologic and molecular features. Histology and Histopathology. 2002; 17:539-554.
19. Choi YL, Moriuchi R, Osawa M, Iwama A, Makishima H, Wada T, Kisanuki H, Kaneda R, Ota J, Koinuma K, Ishikawa M, Takada S, Yamashita Y, Oshimi K, Mano H. Retroviral expression screening of oncogenes in natural killer cell leukemia. Leukemia Research. 2005; 29:943-949.
20. Oshimi K, Kawa K, Nakamura S, Suzuki R, Suzumiya J, Yamaguchi M, Kameoka J, Tagawa S, Imamura N, Ohshima K, Kojya S, Iwatsuki K, Tokura Y, Sato E, Sugimori H. NK-cell neoplasms in Japan. Hematology. 2005; 10:237-245.
21. Zambello R, Falco M, Della Chiesa M, Trentin L, Carollo D, Castriconi R, Cannas G, Carlomagno S, Cabrelle A, Lamy T, Agostini C, Moretta A, Semenzato G, Vitale M. Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes. Blood. 2003; 102:1797-1805.
22. Morice WG, Kurtin PJ, Leibson PJ, Tefferi A, Hanson CA. Demonstration of aberrant T-cell and natural killer-cell antigen expression in all cases of granular lymphocytic leukaemia. British Journal of Haematology. 2003; 120:1026-1036.
23. Epling-Burnette PK, Painter JS, Chaurasia P, Bai F, Wei S, Djeu JY, Loughran TP Jr. Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes. Blood. 2004; 103:3431-3439.
24. Fischer L, Hummel M, Burmeister T, Schwartz S, Thiel E. Skewed expression of natural-killer (NK)-associated antigens on lymphoproliferations of large granular lymphocytes (LGL). Hematological Oncology. 2006; 24:78-85.
25. Allen RC, Zoghbi HY, Moseley AB, Rosenblatt HM, Belmont JW. Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. The American Journal of Human Genetics. 1992; 51:1229-1239.
26. Lima M, Almeida J, Montero AG, Teixeira MA, Queirós ML, Santos AH, Balanzategui A, Estevinho A, Algueró MC, Barcena P, Fonseca S, Amorim ML, Cabeda JM, Pinho L, Gonzalez M, San Miguel J, Justiça B, Orfao A. Clinicobiological, immunophenotypic, and molecular characteristics of monoclonal CD56-/+dim chronic natural killer cell large granular lymphocytosis. American Journal of Pathology. 2004; 165:1117-1127.
27. Jerez A, Clemente MJ, Makishima H, Koskela H, Leblanc F, Peng Ng K, Olson T, Przychodzen B, Afable M, Gomez-Segui I, Guinta K, Durkin L, Hsi ED, McGraw K, Zhang D, Wlodarski MW, Porkka K, Sekeres MA, List A, Mustjoki S, Loughran TP, Maciejewski JP. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood. 2012; 120:3048-3057.
28. Lima M, Teixeira MA, Queiros ML, Leite M, Santos AH, Justiça B, Orfao A. Immunophenotypic characterization of normal blood CD56+lo versus CD56+hi NK-cell subsets and its impact on the understanding of their tissue distribution and functional properties. Blood Cells Molecules and Diseases. 2001; 27:731-743.
29. Zambello R, Teramo A, Barilà G, Gattazzo C, Semenzato G. Activating KIRs in Chronic Lymphoproliferative Disorder of NK Cells: Protection from Viruses and Disease Induction?. Frontiers in Immunology 2014, 5 Art. 72:1-5.
30. Chan JK, Quintanilla-Martinez L, Ferry JA, Peh SC. Extranodal NK/T cell-lymphoma, nasal type. Swerdlow SH, Harris NL, Jaffe EJ, Pirelli SA, Stein H, Thiele J, Vardiman J. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. (4th edn)International Agency for Research of Cancer (IARC)Lyon, France:.
31. Li C, Tian Y, Wang J, Zhu L, Huang L, Wang N, Xu D, Cao Y, Li J, Zhou J. Abnormal immunophenotype provides a key diagnostic marker: a report of 29 cases of de novo aggressive natural killer cell leukemia. Translational Research. 2014; 63:565-577.
32. Ohno Y, Amakawa R, Fukuhara S, Huang CR, Kamesaki H, Amano H, Imanaka T, Takahashi Y, Arita Y, Uchiyama T. Acute transformation of chronic large granular lymphocyte leukemia associated with additional chromosome abnormality. Cancer. 1989; 64:63-67.
33. Matsubara A, Matsumoto M, Takada K, Hato T, Hasegawa H, Tamai T, Yasukawa M Fujita S. Acute transformation of chronic large granular lymphocyte leukemia into an aggressive form associated with preferential organ involvement. Acta Haematologica. 1994; 91:206-210.
34. Rajala HL, Olson T, Clemente MJ, Lagström S, Ellonen P, Lundan T, Hamm DE, Zaman SA, Lopez Marti JM, Andersson EI, Jerez A, Porkka K, Maciejewski JP, Loughran TP, Mustjoki S. The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia. Haematologica. 2015; 100:91-99.
35. Macedo A, Orfao A, Vidriales MB, López-Berges MC, Valverde B, González M, Caballero MD, Ramos F, Martínez M, Fernández-Calvo J, San Miguel JF. Characterization of aberrant phenotypes in acute myeloblastic leukemia. Annals of Hematology. 1995; 70:89-194.
36. Bahia DM, Yamamoto M, Chauffaille M de L, Kimura EY, Bordin JO, Filgueiras MA, Kerbauy J. Aberrant phenotypes in acute myeloid leukemia: a high frequency and its clinical significance. Haematologica. 2001; 86:801-806.
37. Sanchez ML, Almeida J, Vidriales B, López-Berges MC, García-Marcos MA, Moro MJ, Corrales A, Calmuntia MJ, San Miguel JF, Orfao A. Incidence of phenotypic aberrations in a series of 467 patients with B chronic lymphoproliferative disorders: basis for the design of specific four-color stainings to be used for minimal residual disease investigation. Leukemia. 2002; 16:1460-1469.
38. Rawstron AC, Bennett FL, O'Connor SJ, Kwok M, Fenton JA, Plummer M, de Tute R, Owen RG, Richards SJ, Jack AS, Hillmen P. Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. New England Journal of Medicine. 2008; 359:575-583.
39. Ocqueteau M, Orfao A, Almeida J, Bladé J, González M, García-Sanz R, López-Berges C, Moro MJ, Hernández J, Escribano L, Caballero D, Rozman M, San Miguel JF. Immunophenotypic characterization of plasma cells from monoclonal gammopathy of undetermined significance patients. Implications for the differential diagnosis between MGUS and multiple myeloma. American of Journal Pathology. 1998; 152:1655-1665.
40. Rabbani GR, Phyliky RL, Tefferi A. A long-term study of patients with chronic natural killer cell lymphocytosis. British Journal of Haematology. 1999; 106:960-966.
41. Paradis V, Laurent A, Flejou JF, Vidaud M, Bedossa P. Evidence for the polyclonal nature of focal nodular hyperplasia of the liver by the study of X-chromosome inactivation. Hepatology. 1997; 26:891-895.
42. Wu Y, Basir Z, Kajdacsy-Balla A, Strawn E, Macias V, Montgomery K, Guo SW. Resolution of clonal origins for endometriotic lesions using laser capture microdissection and the human androgen receptor (HUMARA) assay. Fertility and Sterility. 2003; 79Suppl 1:710-717.
43. Kopp P, Jaggi R, Tobler A, Borisch B, Oestreicher M, Sabacan L, Jameson JL, Fey MF. Clonal X-inactivation analysis of human tumours using the human androgen receptor gene (HUMARA) polymorphism. a non-radioactive and semiquantitative strategy applicable to fresh and archival tissue. Molecular and Cellular Probes. 1997; 11:217-228.
44. Rajala HL, Eldfors S, Kuusanmäki H, van Adrichem AJ, Olson T, Lagström S, Andersson EI, Jerez A, Clemente MJ, Yan Y, Zhang D, Awwad A, Ellonen P, Kallioniemi O, Wennerberg K, Porkka K, Maciejewski JP, Loughran TP Jr, Heckman C, Mustjoki S. Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. Blood. 2013; 121:4541-4550.
45. Michaels GS, Carr DB, Askenazi M, Fuhrman S, Wen X, Somogyi R. Cluster analysis and data visualization of large-scale gene expression data. Pacific Symposium on Biocomputing. 1998;:42-53.
46. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proceedings of the National Academy of Sciences of the United States of America. 1998; 95:14863-14868.
47. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98:5116-5121.
48. Tibshirani R, Hastie T, Narasimhan B, Chu G. Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proceedings of the National Academy of Sciences of the United States of America. 2002; 99:6567-6572.
49. Pedreira CE, Costa ES, Almeida J, Fernandez C, Quijano S, Flores J, Barrena S, Lecrevisse Q, Van Dongen JJ, Orfao A. A probabilistic approach for the evaluation of minimal residual disease by multiparameter flow cytometry in leukemic B-cell chronic lymphoproliferative disorders. Cytometry A. 2008; 73:1141-1150.
50. Pedreira CE, Costa ES, Barrena S, Lecrevisse Q, Almeida J, van Dongen JJ, Orfao A. Generation of flow cytometry data files with a potentially infinite number of dimensions. Cytometry A. 2008; 73:834-846.
51. Costa ES, Pedreira CE, Barrena S, Lecrevisse Q, Flores J, Quijano S, Almeida J, Garcia-Macias MC, Bottcher S, Van Dongen JJ, Orfao A. Automated pattern-guided principal component analysis vs expert-based immunophenotypic classification of B-cell chronic lymphoproliferative disorders: a step forward in the standardization of clinical immunophenotyping. Leukemia. 2010; 24:1927-1933.