Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy

Cell Stem Cell

Volumn 17, Issue 4, 2015, Pages 486-498

  D'Addio, Francesca ^a,b   La Rosa, Stefano ^c   Maestroni, Anna ^b   Jung, Peter ^d   Orsenigo, Elena ^b   Ben Nasr, Moufida ^a,b   Tezza, Sara ^a,b   Bassi, Roberto ^a,b   Finzi, Giovanna ^c   Marando, Alessandro ^c   Vergani, Andrea ^a,b   Frego, Roberto ^b   Albarello, Luca ^b   Andolfo, Annapaola ^b   Manuguerra, Roberta ^e   Viale, Edi ^b   Staudacher, Carlo ^b   Corradi, Domenico ^e   Batlle, Eduard ^d,f   Breault, David ^a   Secchi, Antonio ^b,g   Folli, Franco ^h,i   Fiorina, Paolo ^a,b   more..

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c OSPEDALE DI CIRCOLO   (Italy)

^d INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^e UNIVERSITY OF PARMA   (Italy)

^f INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^g VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^h UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

ⁱ UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

colonic stem cells; diabetic enteropathy; diabetic nephropathy; hyperglycemia; IGF I; IGFBP3; kidney transplantation; pancreas transplantation; type 1 diabetes; type 2 diabetes; uremia

Indexed keywords

C PEPTIDE; CASPASE 8; CASPASE 9; INSULIN; PROTEIN BCL 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; IGF1 PROTEIN, HUMAN; IGFBP3 PROTEIN, HUMAN; MEMBRANE PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; COLONIC STEM CELL; CONTROLLED STUDY; CYTOPLASM; DIABETIC ENTEROPATHY; END STAGE RENAL DISEASE; ENTEROPATHY; EPITHELIUM HYPERPLASIA; FEMALE; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINAL STEM CELL; INTESTINE MUCOSA; KIDNEY PANCREAS TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; ANIMAL; BLOOD; COLON; CYTOLOGY; DIABETES MELLITUS; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; PROTEOMICS; STEM CELL;

ANIMALS; COLON; DIABETES COMPLICATIONS; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; INTESTINAL MUCOSA; MEMBRANE PROTEINS; MICE; PROTEOMICS; STEM CELLS;

EID: 84952313820     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2015.07.010     Document Type: Article

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