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Volumn 11, Issue 12, 2015, Pages 1439-1451

Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses

(178)  Mukherjee, Shubhabrata a   Walter, Stefan b   Kauwe, John S K c   Saykin, Andrew J d   Bennett, David A e   Larson, Eric B f   Crane, Paul K a   Glymour, M Maria b   Albert, Marilyn S g   Albin, Roger L h,i,j   Apostolova, Liana G k   Arnold, Steven E l   Asthana, Sanjay m,n   Atwood, Craig S m,n   Baldwin, Clinton T o   Barber, Robert C p   Barmada, Michael M q   Barnes, Lisa L r   Beach, Thomas G s   Becker, James T t   more..


Author keywords

Alzheimer's disease; Dementia; Mendelian randomization; Obesity

Indexed keywords

ALGORITHM; ALZHEIMER DISEASE; ARTICLE; BODY MASS; CONTROLLED STUDY; DEMENTIA; DISEASE ASSOCIATION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MENDELIAN RANDOMIZATION ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; COMPLICATION; FEMALE; GENETICS; GENOTYPE; MALE; OBESITY; RISK FACTOR; STATISTICAL MODEL; VERY ELDERLY;

EID: 84952308113     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2015.05.015     Document Type: Article
Times cited : (46)

References (47)
  • 1
    • 84876260183 scopus 로고    scopus 로고
    • Midlife obesity and dementia: Meta-analysis and adjusted forecast of dementia prevalence in the United States and China
    • M. Loef, and H. Walach Midlife obesity and dementia: Meta-analysis and adjusted forecast of dementia prevalence in the United States and China Obesity (Silver Spring) 21 2013 E51 E55
    • (2013) Obesity (Silver Spring) , vol.21 , pp. E51-E55
    • Loef, M.1    Walach, H.2
  • 2
    • 80052520103 scopus 로고    scopus 로고
    • Childhood environmental and genetic predictors of adulthood obesity: The cardiovascular risk in young Finns study
    • M. Juonala, J. Juhola, C.G. Magnussen, P. Wurtz, J.S. Viikari, R. Thomson, and et al. Childhood environmental and genetic predictors of adulthood obesity: The cardiovascular risk in young Finns study J Clin Endocrinol Metab 96 2011 E1542 E1549
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. E1542-E1549
    • Juonala, M.1    Juhola, J.2    Magnussen, C.G.3    Wurtz, P.4    Viikari, J.S.5    Thomson, R.6
  • 3
    • 0141634200 scopus 로고    scopus 로고
    • Childhood IQ, social class, deprivation, and their relationships with mortality and morbidity risk in later life: Prospective observational study linking the Scottish Mental Survey 1932 and the Midspan studies
    • C.L. Hart, M.D. Taylor, G. Davey Smith, L.J. Whalley, J.M. Starr, D.J. Hole, and et al. Childhood IQ, social class, deprivation, and their relationships with mortality and morbidity risk in later life: Prospective observational study linking the Scottish Mental Survey 1932 and the Midspan studies Psychosom Med 65 2003 877 883
    • (2003) Psychosom Med , vol.65 , pp. 877-883
    • Hart, C.L.1    Taylor, M.D.2    Davey Smith, G.3    Whalley, L.J.4    Starr, J.M.5    Hole, D.J.6
  • 4
    • 53949092997 scopus 로고    scopus 로고
    • Lifecourse social conditions and racial and ethnic patterns of cognitive aging
    • M.M. Glymour, and J. Manly Lifecourse social conditions and racial and ethnic patterns of cognitive aging Neuropsychol Rev 18 2008 223 254
    • (2008) Neuropsychol Rev , vol.18 , pp. 223-254
    • Glymour, M.M.1    Manly, J.2
  • 6
    • 77952226981 scopus 로고    scopus 로고
    • Occupational exposure to pesticides increases the risk of incident AD: The Cache County Study
    • K.M. Hayden, M.C. Norton, D. Darcey, T. Østbye, P.P. Zandi, J.C.S. Breitner, and et al. Occupational exposure to pesticides increases the risk of incident AD: The Cache County Study Neurology 74 2010 1524 1530
    • (2010) Neurology , vol.74 , pp. 1524-1530
    • Hayden, K.M.1    Norton, M.C.2    Darcey, D.3    Østbye, T.4    Zandi, P.P.5    Breitner, J.C.S.6
  • 7
    • 84871720754 scopus 로고    scopus 로고
    • Advanced psychometric analysis and the Alzheimer's Disease Neuroimaging Initiative: Reports from the 2011 Friday Harbor conference
    • D. Mungas, P.K. Crane, L.E. Gibbons, J.J. Manly, M.M. Glymour, and R.N. Jones Advanced psychometric analysis and the Alzheimer's Disease Neuroimaging Initiative: Reports from the 2011 Friday Harbor conference Brain Imaging Behav 6 2012 485 488
    • (2012) Brain Imaging Behav , vol.6 , pp. 485-488
    • Mungas, D.1    Crane, P.K.2    Gibbons, L.E.3    Manly, J.J.4    Glymour, M.M.5    Jones, R.N.6
  • 8
    • 70450255115 scopus 로고    scopus 로고
    • Review: Obesity and Alzheimer's disease: A link between body weight and cognitive function in old age
    • E.K. Naderali, S.H. Ratcliffe, and M.C. Dale Review: Obesity and Alzheimer's disease: A link between body weight and cognitive function in old age Am J Alzheimers Dis Other Demen 24 2009 445 449
    • (2009) Am J Alzheimers Dis Other Demen , vol.24 , pp. 445-449
    • Naderali, E.K.1    Ratcliffe, S.H.2    Dale, M.C.3
  • 9
    • 67049137261 scopus 로고    scopus 로고
    • Mendelian randomization: Nature's randomized trial in the post-genome era
    • G. Thanassoulis, and C.J. O'Donnell Mendelian randomization: Nature's randomized trial in the post-genome era JAMA 301 2009 2386
    • (2009) JAMA , vol.301 , pp. 2386
    • Thanassoulis, G.1    O'Donnell, C.J.2
  • 10
    • 0037322022 scopus 로고    scopus 로고
    • 'Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease?
    • G. Davey Smith, and S. Ebrahim 'Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32 2003 1 22
    • (2003) Int J Epidemiol , vol.32 , pp. 1-22
    • Davey Smith, G.1    Ebrahim, S.2
  • 11
    • 84906838227 scopus 로고    scopus 로고
    • Mendelian randomization: Genetic anchors for causal inference in epidemiological studies
    • G.D. Smith, and G. Hemani Mendelian randomization: Genetic anchors for causal inference in epidemiological studies Hum Mol Genet 2014 ddu328
    • (2014) Hum Mol Genet , pp. ddu328
    • Smith, G.D.1    Hemani, G.2
  • 12
    • 84901602675 scopus 로고    scopus 로고
    • Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity
    • A. Hinney, O. Albayrak, J. Antel, A.L. Volckmar, R. Sims, J. Chapman, and et al. Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity Am J Med Genet B Neuropsychiatr Genet 165B 2014 283 293
    • (2014) Am J Med Genet B Neuropsychiatr Genet , vol.165 B , pp. 283-293
    • Hinney, A.1    Albayrak, O.2    Antel, J.3    Volckmar, A.L.4    Sims, R.5    Chapman, J.6
  • 13
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • E.K. Speliotes, C.J. Willer, S.I. Berndt, K.L. Monda, G. Thorleifsson, A.U. Jackson, and et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index Nat Genet 42 2010 937 948
    • (2010) Nat Genet , vol.42 , pp. 937-948
    • Speliotes, E.K.1    Willer, C.J.2    Berndt, S.I.3    Monda, K.L.4    Thorleifsson, G.5    Jackson, A.U.6
  • 14
    • 79955464911 scopus 로고    scopus 로고
    • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
    • A.C. Naj, G. Jun, G.W. Beecham, L.S. Wang, B.N. Vardarajan, J. Buros, and et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease Nat Genet 43 2011 436 441
    • (2011) Nat Genet , vol.43 , pp. 436-441
    • Naj, A.C.1    Jun, G.2    Beecham, G.W.3    Wang, L.S.4    Vardarajan, B.N.5    Buros, J.6
  • 15
    • 0000366020 scopus 로고
    • An overview of the Health and Retirement Study
    • F. Juster, and R. Suzman An overview of the Health and Retirement Study J Human Res 30 suppl 1995 S7 56
    • (1995) J Human Res , vol.30 , pp. S7-S56
    • Juster, F.1    Suzman, R.2
  • 17
    • 0010618058 scopus 로고    scopus 로고
    • Documentation of cognitive functioning measures in the health and retirement study
    • Survey Research Center, University of Michigan Ann Arbor, MI
    • M.B. Ofstedal, G.F. Fisher, and A.R. Herzog Documentation of cognitive functioning measures in the health and retirement study. HRS Documentation Report 2005 Survey Research Center, University of Michigan Ann Arbor, MI
    • (2005) HRS Documentation Report
    • Ofstedal, M.B.1    Fisher, G.F.2    Herzog, A.R.3
  • 18
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • G. McKhann Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease Neurology 34 1984 939 944
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1
  • 20
    • 84898967273 scopus 로고    scopus 로고
    • Assessing causality in the association between child adiposity and physical activity levels: A Mendelian randomization analysis
    • R.C. Richmond, G.D. Smith, A.R. Ness, M. den Hoed, G. McMahon, and N.J. Timpson Assessing causality in the association between child adiposity and physical activity levels: A Mendelian randomization analysis PLoS Med 11 2014 e1001618
    • (2014) PLoS Med , vol.11
    • Richmond, R.C.1    Smith, G.D.2    Ness, A.R.3    Den Hoed, M.4    McMahon, G.5    Timpson, N.J.6
  • 21
    • 84890119618 scopus 로고    scopus 로고
    • Pleiotropic effects of obesity-susceptibility loci on metabolic traits: A meta-analysis of up to 37,874 individuals
    • J.V. van Vliet-Ostaptchouk, M. den Hoed, J. Luan, J.H. Zhao, K.K. Ong, P.J. van der Most, and et al. Pleiotropic effects of obesity-susceptibility loci on metabolic traits: A meta-analysis of up to 37,874 individuals Diabetologia 56 2013 2134 2146
    • (2013) Diabetologia , vol.56 , pp. 2134-2146
    • Van Vliet-Ostaptchouk, J.V.1    Den Hoed, M.2    Luan, J.3    Zhao, J.H.4    Ong, K.K.5    Van Der Most, P.J.6
  • 23
    • 84856718639 scopus 로고    scopus 로고
    • Credible Mendelian randomization studies: Approaches for evaluating the instrumental variable assumptions
    • M.M. Glymour, E. Tchetgen Tchetgen, and J.M. Robins Credible Mendelian randomization studies: Approaches for evaluating the instrumental variable assumptions Am J Epidemiol 175 2012 332 339
    • (2012) Am J Epidemiol , vol.175 , pp. 332-339
    • Glymour, M.M.1    Tchetgen Tchetgen, E.2    Robins, J.M.3
  • 24
    • 0000250716 scopus 로고
    • Specification tests in econometrics
    • J.A. Hausman Specification tests in econometrics Econometrica 46 1978 1251 1271
    • (1978) Econometrica , vol.46 , pp. 1251-1271
    • Hausman, J.A.1
  • 25
    • 0001755034 scopus 로고
    • The estimation of economic relationships using instrumental variables
    • J. Sargan The estimation of economic relationships using instrumental variables Econometrica 26 1958 393 415
    • (1958) Econometrica , vol.26 , pp. 393-415
    • Sargan, J.1
  • 26
    • 84885840876 scopus 로고    scopus 로고
    • Mendelian randomization analysis with multiple genetic variants using summarized data
    • S. Burgess, A. Butterworth, and S.G. Thompson Mendelian randomization analysis with multiple genetic variants using summarized data Genet Epidemiol 37 2013 658 665
    • (2013) Genet Epidemiol , vol.37 , pp. 658-665
    • Burgess, S.1    Butterworth, A.2    Thompson, S.G.3
  • 27
    • 84927727976 scopus 로고    scopus 로고
    • Instrumental variable analysis with a nonlinear exposure-outcome relationship
    • S. Burgess, N.M. Davies, and S.G. Thompson Instrumental variable analysis with a nonlinear exposure-outcome relationship Epidemiology 25 2014 877 885
    • (2014) Epidemiology , vol.25 , pp. 877-885
    • Burgess, S.1    Davies, N.M.2    Thompson, S.G.3
  • 28
    • 80051669619 scopus 로고    scopus 로고
    • The projected effect of risk factor reduction on Alzheimer's disease prevalence
    • D.E. Barnes, and K. Yaffe The projected effect of risk factor reduction on Alzheimer's disease prevalence Lancet Neurol 10 2011 819 828
    • (2011) Lancet Neurol , vol.10 , pp. 819-828
    • Barnes, D.E.1    Yaffe, K.2
  • 29
    • 84904264999 scopus 로고    scopus 로고
    • Potential for primary prevention of Alzheimer's disease: An analysis of population-based data
    • S. Norton, F.E. Matthews, D.E. Barnes, K. Yaffe, and C. Brayne Potential for primary prevention of Alzheimer's disease: An analysis of population-based data Lancet Neurol 13 2014 788 794
    • (2014) Lancet Neurol , vol.13 , pp. 788-794
    • Norton, S.1    Matthews, F.E.2    Barnes, D.E.3    Yaffe, K.4    Brayne, C.5
  • 30
    • 57149142096 scopus 로고    scopus 로고
    • Overweight and obesity in old age are not associated with greater dementia risk
    • A.K. Dahl, M. Löppönen, R. Isoaho, S. Berg, and S.L. Kivelä Overweight and obesity in old age are not associated with greater dementia risk J Am Geriatr Soc 56 2008 2261 2266
    • (2008) J Am Geriatr Soc , vol.56 , pp. 2261-2266
    • Dahl, A.K.1    Löppönen, M.2    Isoaho, R.3    Berg, S.4    Kivelä, S.L.5
  • 32
    • 77954517269 scopus 로고    scopus 로고
    • Associations between BMI and the FTO gene are age dependent: Results from the GINI and LISA birth cohort studies up to age 6 years
    • P. Rzehak, A. Scherag, H. Grallert, S. Sausenthaler, S. Koletzko, C. Bauer, and et al. Associations between BMI and the FTO gene are age dependent: Results from the GINI and LISA birth cohort studies up to age 6 years Obes Facts 3 2010 173 180
    • (2010) Obes Facts , vol.3 , pp. 173-180
    • Rzehak, P.1    Scherag, A.2    Grallert, H.3    Sausenthaler, S.4    Koletzko, S.5    Bauer, C.6
  • 33
    • 84876513251 scopus 로고    scopus 로고
    • The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: The PAGE Study
    • M. Graff, P. Gordon-Larsen, U. Lim, J.H. Fowke, S.-A. Love, M. Fesinmeyer, and et al. The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: The PAGE Study Diabetes 62 2013 1763 1767
    • (2013) Diabetes , vol.62 , pp. 1763-1767
    • Graff, M.1    Gordon-Larsen, P.2    Lim, U.3    Fowke, J.H.4    Love, S.-A.5    Fesinmeyer, M.6
  • 34
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • T.M. Frayling, N.J. Timpson, M.N. Weedon, E. Zeggini, R.M. Freathy, C.M. Lindgren, and et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science 316 2007 889 894
    • (2007) Science , vol.316 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3    Zeggini, E.4    Freathy, R.M.5    Lindgren, C.M.6
  • 35
    • 84859224327 scopus 로고    scopus 로고
    • Measuring adiposity in patients: The utility of body mass index (BMI), percent body fat, and leptin
    • N.R. Shah, and E.R. Braverman Measuring adiposity in patients: the utility of body mass index (BMI), percent body fat, and leptin PLoS One 7 2012 e33308
    • (2012) PLoS One , vol.7
    • Shah, N.R.1    Braverman, E.R.2
  • 37
    • 84910647593 scopus 로고    scopus 로고
    • How to report instrumental variable analyses
    • S. Swanson, and M. Hernan How to report instrumental variable analyses Epidemiology 24 2013 924 933
    • (2013) Epidemiology , vol.24 , pp. 924-933
    • Swanson, S.1    Hernan, M.2
  • 38
    • 84875610283 scopus 로고    scopus 로고
    • Commentary: Building an evidence base for mendelian randomization studies: Assessing the validity and strength of proposed genetic instrumental variables
    • E.J. Tchetgen Tchetgen, S. Walter, and M.M. Glymour Commentary: Building an evidence base for mendelian randomization studies: Assessing the validity and strength of proposed genetic instrumental variables Int J Epidemiol 42 2013 328 331
    • (2013) Int J Epidemiol , vol.42 , pp. 328-331
    • Tchetgen Tchetgen, E.J.1    Walter, S.2    Glymour, M.M.3
  • 40
    • 84871784819 scopus 로고    scopus 로고
    • Association of all-cause mortality with overweight and obesity using standard body mass index categories: A systematic review and meta-analysis
    • K.M. Flegal, B.K. Kit, H. Orpana, and B.I. Graubard Association of all-cause mortality with overweight and obesity using standard body mass index categories: A systematic review and meta-analysis JAMA 309 2013 71 82
    • (2013) JAMA , vol.309 , pp. 71-82
    • Flegal, K.M.1    Kit, B.K.2    Orpana, H.3    Graubard, B.I.4
  • 41
    • 49549116657 scopus 로고    scopus 로고
    • Does obesity shorten life? the importance of well-defined interventions to answer causal questions
    • M.A. Hernán, and S.L. Taubman Does obesity shorten life? The importance of well-defined interventions to answer causal questions Int J Obes 2008 S8 S14
    • (2008) Int J Obes , pp. S8-S14
    • Hernán, M.A.1    Taubman, S.L.2
  • 43
    • 84897855294 scopus 로고    scopus 로고
    • Obesity-associated variants within FTO form long-range functional connections with IRX3
    • S. Smemo, J.J. Tena, K.-H. Kim, E.R. Gamazon, N.J. Sakabe, C. Gómez-Marín, and et al. Obesity-associated variants within FTO form long-range functional connections with IRX3 Nature 507 2014 371 375
    • (2014) Nature , vol.507 , pp. 371-375
    • Smemo, S.1    Tena, J.J.2    Kim, K.-H.3    Gamazon, E.R.4    Sakabe, N.J.5    Gómez-Marín, C.6
  • 44
    • 57749121512 scopus 로고    scopus 로고
    • An obesity-associated FTO gene variant and increased energy intake in children
    • J.E. Cecil, R. Tavendale, P. Watt, M.M. Hetherington, and C.N.A. Palmer An obesity-associated FTO gene variant and increased energy intake in children N Engl J Med 359 2008 2558 2566
    • (2008) N Engl J Med , vol.359 , pp. 2558-2566
    • Cecil, J.E.1    Tavendale, R.2    Watt, P.3    Hetherington, M.M.4    Palmer, C.N.A.5
  • 46
    • 84875922294 scopus 로고    scopus 로고
    • Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
    • T. Tanaka, J.S. Ngwa, F.J. van Rooij, M.C. Zillikens, M.K. Wojczynski, A.C. Frazier-Wood, and et al. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake Am J Clin Nutr 97 2013 1395 1402
    • (2013) Am J Clin Nutr , vol.97 , pp. 1395-1402
    • Tanaka, T.1    Ngwa, J.S.2    Van Rooij, F.J.3    Zillikens, M.C.4    Wojczynski, M.K.5    Frazier-Wood, A.C.6


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