Monitoring of Clostridium difficile colonization in preterm infants in neonatal intensive care units

Pediatric Gastroenterology, Hepatology and Nutrition

Volumn 15, Issue 1, 2012, Pages 29-37

  Chang, Ju Young ^a   Shim, Jung Ok ^a   Ko, Jae Sung ^a   Seo, Jeong Kee ^a   Lee, Jin A ^a   Kim, Han Suk ^a   Choi, Jung Hwan ^a   Shin, Sue ^a   Shin, Son Moon ^b  

^a Seoul National University   (South Korea)

^b Catholic Kwandong University   (South Korea)

Author keywords

Breast milk feeding; Clostridium difficile; NICU; Preterm infants

Indexed keywords

EID: 84952023136     PISSN: 22348646     EISSN: 22348840     Source Type: Journal    
DOI: 10.5223/pghn.2012.15.1.29     Document Type: Article

References (38)

1. Kim BC, Yang HR, Jeong SJ, Lee KH, Kim JE, Ko JS, et al. Clostridium difficile colitis in childhood: associated antibiotics. Korean J Pediatr Gastroenterol Nutr 2002;5:143-9.
2. Bolton RP, Tait SK, Dear PR, Losowsky MS. Asymptomatic neonatal colonisation by Clostridium difficile. Arch Dis Child 1984;59:466-72.
3. Enoch DA, Butler MJ, Pai S, Aliyu SH, Karas JA. Clostridium difficile in children: colonisation and disease. J Infect 2011;63:105-13.
4. Genta VM, Gilligan PH, McCarthy LR. Clostridium difficile peritonitis in a neonate. A case report. Arch Pathol Lab Med 1984;108:82-3.
5. Han VK, Sayed H, Chance GW, Brabyn DG, Shaheed WA. An outbreak of Clostridium difficile necrotizing enterocolitis: a case for oral vancomycin therapy? Pediatrics 1983;71:935-41.
6. Cardines R, Luzzi I, Menichella G, Virgili Q, Mastrantonio P. Clostridium difficile in preterm neonates. Microbiologica 1988;11:259-61.
7. Enad D, Meishlich D, Brodsky NL, Hurt H. Is Clostridium difficile a pathogen in the newborn intensive csre unit? A prospective evalauation. J Perinatol 1997;17:355-9.
8. McFarland LV. Update on the changing epidemiology of Clostridium difficile-associated disease. Nat Clin Pract Gastroenterol Hepatol 2008;5:40-8.
9. Hecker MT, Riggs MM, Hoyen CK, Lancioni C, Donskey CJ. Recurrent infection with epidemic Clostridium difficile in a peripartum woman whose infant was asymptomatically colonized with the same strain. Clin Infect Dis 2008;46:956-7.
10. Rousseau C, Lemee L, Le Monnier A, Poilane I, Pons J, Collignon A. Prevalence and diversity of Clostidium difficile strains in infants. J of Med Microbiol 2011;60: 1112-8.
11. Kalliomaki M, Collado MC, Salminen S, Isolauri E. Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr 2008;87:534-8.
12. Fanaro S, Chierici R, Guerrini P, Vigi V. Intestinal microflora in early infancy:composition and development. Acta Paediatr Suppl 2003;91:48-55.
13. Penders J, Thijs C, Vink C, Stelma F, Smijders B, Kummeling I, et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 2006;118:511-21.
14. Cooperstock M, Riegle L, WoodruffCW, Onderdonk A. Influence of age, sex, and diet on asymptomatic colonization of infants with Clostridium difficile. J Clin Microbiol 1983;17:830-3.
15. Gewolb IH, Schwalbe RS, Taciak VL, Harrison TS, Panigrahi P. Stool microflora in extremely low birthweight infants. Arch Dis Child Fetal Neonatal Ed 1999;80:F167-73.
16. Schwiertz A, Gruhl B, Lobnitz M, Michel P, Radke M, Blaut M. Development of the intestinal bacterial composition in hospitalized preterm infants in comparison with breast-fed, full-term infants. Pediatr Res 2003;54:393-9.
17. Mshvildadze M, Neu J, Shuster J, Theriaque D, Li N, Mai V. Intestinal microbial ecology in premature infants assessed with non-culture-based techniques. J Pediatr 2010;156:20-5.
18. Ferraris L, Butel MJ, Campeotto F, Vodovar M, Roze JC, Aires J. Clostridia in premature neonates'gut: incidence, antibiotic susceptibility, and perinatal determinants. PLoS One 2012;7:e30594.
19. el-Mohandes AE, Keiser JF, Refat M, Jackson BJ. Prevalence and toxigenicity of Clostridium difficile isolates in fecal microflora of preterm infants in the intensive care nursery. Biol Neonate 1993;63:225-9.
20. Chang JY, Shin SM, Chun J, Lee JH, Seo JK. Pyrosequencing-based molecular monitoring of the intestinal bacterial colonization in preterm infants. J Pediatr Gastroenterol Nutr 2011;53:512-9.
21. Li F, Hullar MA, Lampe JW. Optimization of terminal restriction fragment polymorphism (TRFLP) analysis of human gut microbiota. J Microbiol Methods 2007;68:303-11.
22. Rinttila T, Kassinen A, Malinen E, Krogius L, Palva A. Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR. J Appl Microbiol 2004;97:1166-77.
23. Kato H, Kato N, Watanabe K, Iwai N, Nakamura H, Yamamoto T, et al. Identification of toxin A-negative, toxin B-positive Clostridium difficile by PCR. J Clin Microbiol 1998;36:2178-82.
24. Shin BM, Yoo SJ, Oh HJ. Comparison of two enzyme immunoassay for detection of Clostridium difficile toxin A and toxin B. Korean J Lab Med 2009;29:122-6.
25. Samie A, Obi CL, Franasiak J, Archbald-Pannone L, Bessong PO, Alcantara-Warren C et al. PCR detection of Clostridium difficile triose phosphate isomerase (tpi), toxin A(tcdA), toxinB (tcdB), binary toxin (cdtA, cdtB), and tcdC genes in Vhembe district, South Africa. Am J Trop Med Hyg 2008;78:577-85.
26. Al-Jumaili IJ, Shibley M, Lishman AH, Record CO. Incidence and origin of Clostridium difficile in neonates. J Clin Microbiol 1984;19:77-8.
27. Blakey JL, Lubitz L, Barnes GL, Bishop RF, Campbell NT, Gillam GL. Development of gut colonisation in pre-term neonates. J Med Microbiol 1982;15:519-29.
28. Benno Y, Sawada K, Mitsuoka T. The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants. Microbiol Immunol 1984;28: 975-86.
29. Penders J, Vink C, Driessen C, London N, Thijs C, Stobberingh EE. Quantification of Bifidobacterium spp., Escherichia coli and Clostridium difficile in faecal samples of breast-fed and formula-fed infants by real-time PCR. FEMS Microbiol Lett 2005;243:141-7.
30. Péchine S, Janoir C, Boureau H, Gleizes A, Tsapis N, Hoys S, et al. Diminished intestinal colonization by Clostridium difficile and immune response in mice after mucosal immunization with surface proteins of Clostridium difficile. Vaccine 2007;25:3946-54.
31. Bourlioux P, Koletzko B, Guarner F, Braesco V. The intestine and its microflora are partners for the protection of the host: report on the Danone Symposium "The Intelligent Intestine, "held in Paris, June 14, 2002 American Journal of Clinical Nutrition 2003;78: 675-83.
32. Magne F, Abely M, Boyer F, Morville P, Pochart P, Suau A. Low species diversity and high interindividual variability in faeces of preterm infants as revealed by sequences of 16S rRNA genes and PCR-temporal temperature gradient gel electrophoresis profiles. FEMS Microbiol Ecol 2006;57:128-38.
33. Westerbeek EA, van den Berg A, Lafeber HN, Knol J, Fetter WP, van Elburg RM. The intestinal bacterial colonisation in preterm infants: a review of the literature. Clin Nutr 2006;25:361-8.
34. Butel MJ, Roland N, Hibert A, Popot F, Favre A, Tessedre A, et al. Clostridial pathogenicity in experimental necrotising enterocolitis in gnotobiotic quails and protective role of bifidobacteria. Journal of Medical Microbiology 1998;47:391-9.
35. Rousseau C, Levenez F, Fouqueray C, Dore J, Collignon A, Lepage P. Clostridium difficile Colonization in Early Infancy Is Accompanied by Changes in Intestinal Microbiota Composition. Journal of Clinical Microbiology 2011;49:858-65.
36. Sjögren YM, Tomicic S, Lundberg A, Bbottcher M, Bjorksten B, Sverremark-Ekstrom E, et al. Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses. Clinical and Experimental Allergy 2009;39:1842-51.
37. Morelli L. Postnatal development of intestinal microflora as influenced by infant nutrition. Journal of Nutrition 2008;138:1791s-5s.
38. Collignon A, Ticchi L, Depitre C, Gaudelus J, Delmee M, Corthier G. Heterogeneity of Clostridium-Difficile Isolates from Infants. European Journal of Pediatrics 1993;152:319-22.