Direct comparison of a natural loss-of-function single nucleotide polymorphism with a targeted deletion in the Ncf1 gene reveals different phenotypes

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  Sareila, Outi ^a   Hagert, Cecilia ^a,b   Rantakari, Pia ^a,c   Poutanen, Matti ^c   Holmdahl, Rikard ^a,d  

^a UNIVERSITY OF TURKU   (Finland)

^b National Doctoral Programme in Informational and Structural Biology   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; REACTIVE OXYGEN METABOLITE; SEX HORMONE; STAT1 PROTEIN; CYBB PROTEIN, MOUSE; MEMBRANE PROTEIN; NEUTROPHIL CYTOSOLIC FACTOR 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STAT1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE; GENE DELETION; GENE SILENCING; GENE TARGETING; KNOCKOUT MOUSE; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NCF1 GENE; NONHUMAN; OVARIECTOMY; PHENOTYPE; PROTEIN EXPRESSION; PSORIATIC ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; CELL LINE; EXPERIMENTAL ARTHRITIS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; PATHOLOGY;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CELL LINE; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENE TARGETING; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; NADPH OXIDASE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; REACTIVE OXYGEN SPECIES; STAT1 TRANSCRIPTION FACTOR;

EID: 84951865747     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0141974     Document Type: Article

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