Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis

BMC Musculoskeletal Disorders

Volumn 11, Issue , 2010, Pages

  Jochems, Caroline ^a   Islander, Ulrika ^a   Erlandsson, Malin ^a   Engdahl, Cecilia ^a   Lagerquist, Marie ^a   Gjertsson, Inger ^a   Ohlsson, Claes ^a   Holmdahl, Rikard ^b,c   Carlsten, Hans ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Turku University   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

17 BETA ESTRADIOL 3 BENZOATE; 6 HYDROXY 2 (4 HYDROXYPHENYL) 3 [4 [2 (1 PYRROLIDINYL)ETHOXY]BENZOYL]BENZO[B]THIOPHENE; COLLAGEN; INTERLEUKIN 6; SEX HORMONE; UNCLASSIFIED DRUG; ESTRADIOL; ESTROGEN; NEUTROPHIL CYTOSOLIC FACTOR 1; RALOXIFENE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ART THERAPY; ARTICLE; BLOOD LEVEL; BONE DENSITY; CARTILAGE; CHRONIC ARTHRITIS; CHRONIC DISEASE; CYTOKINE PRODUCTION; DISEASE MARKER; EXPERIMENT; FEMALE; HISTOPATHOLOGY; IMMUNIZATION; INFLAMMATION; JOINT; JOINT DESTRUCTION; MOUSE; MOUSE STRAIN; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; POSTMENOPAUSE; SERUM; TURNOVER TIME; ANIMAL; ARTHRITIS; DBA MOUSE; DISEASE COURSE; DISEASE MODEL; DRUG EFFECT; GENETICS; METABOLISM; MOUSE MUTANT; MUTATION; OSTEOARTHRITIS; PATHOPHYSIOLOGY; PHYSIOLOGY; PREVALENCE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CARTILAGE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ESTRADIOL; ESTROGENS; FEMALE; INTERLEUKIN-6; MICE; MICE, INBRED DBA; MICE, MUTANT STRAINS; MUTATION; NADPH OXIDASE; OSTEOARTHRITIS; OVARIECTOMY; PREVALENCE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATORS;

EID: 78650135866     PISSN: None     EISSN: 14712474     Source Type: Journal    
DOI: 10.1186/1471-2474-11-284     Document Type: Article

References (44)

1. The prevalence and severity of rheumatoid arthritis in Oslo. Results from a county register and a population survey. TK Kvien A Glennas OG Knudsrod LM Smedstad P Mowinckel O Forre, Scand J Rheumatol 1997 26 412 418 10.3109/03009749709065712 9433400
2. Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period. MF Doran GR Pond CS Crowson WM O'Fallon SE Gabriel, Arthritis Rheum 2002 46 625 631 10.1002/art.509 11920397
3. Epidemiological aspects of rheumatoid arthritis: the sex ratio. TK Kvien T Uhlig S Odegard MS Heiberg, Ann N Y Acad Sci 2006 1069 212 222 10.1196/annals.1351.019 16855148
4. Oral contraceptives and rheumatoid arthritis: results from a primary care-based incident case-control study. P Brennan C Bankhead A Silman D Symmons, Semin Arthritis Rheum 1997 26 817 823 10.1016/S0049-0172(97)80025-X 9213380
5. Risk factors for the development of rheumatoid arthritis. JE Oliver AJ Silman, Scand J Rheumatol 2006 35 169 174 10.1080/03009740600718080 16766362
6. Influence of hormone replacement therapy on disease progression and bone mineral density in rheumatoid arthritis. H Forsblad D'Elia A Larsen LA Mattsson E Waltbrand G Kvist D Mellstrom T Saxne C Ohlsson E Nordborg H Carlsten, J Rheumatol 2003 30 1456 1463 12858441
7. Effect of oestrogen treatment on clinical and laboratory manifestations of rheumatoid arthritis. JW Bijlsma O Huber-Bruning JH Thijssen, Ann Rheum Dis 1987 46 777 779 10.1136/ard.46.10.777 3318724
8. A randomised controlled trial of the effect of hormone replacement therapy on disease activity in postmenopausal rheumatoid arthritis. GM Hall M Daniels EC Huskisson TD Spector, Ann Rheum Dis 1994 53 112 116 10.1136/ard.53.2.112 8129455
9. Effects of hormone replacement therapy in rheumatoid arthritis: a double blind placebo-controlled study. AG MacDonald EA Murphy HA Capell UZ Bankowska SH Ralston, Ann Rheum Dis 1994 53 54 57 10.1136/ard.53.1.54 8311557
10. Female sex hormones suppress development of collagen-induced arthritis in mice. R Holmdahl L Jansson M Andersson, Arthritis Rheum 1986 29 1501 1509 10.1002/art.1780291212 3801072
11. Oestrogen induced suppression of collagen arthritis. IV: Progesterone alone does not affect the course of arthritis but enhances the oestrogen-mediated therapeutic effect. L Jansson R Holmdahl, J Reprod Immunol 1989 15 141 150 10.1016/0165-0378(89)90033-8 2769647
12. Enhancement of collagen-induced arthritis in female mice by estrogen receptor blockage. L Jansson R Holmdahl, Arthritis Rheum 2001 44 2168 2175 10.1002/1529-0131(200109)44:9<2168::AID-ART3703.0.CO;2-2 11592382
13. Autoimmunity to type II collagen an experimental model of arthritis. DE Trentham AS Townes AH Kang, J Exp Med 1977 146 857 868 10.1084/jem.146.3.857 894190
14. Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis. C Jochems U Islander A Kallkopf M Lagerquist C Ohlsson H Carlsten, Arthritis Rheum 2007 56 3261 3270 10.1002/art.22873 17907171
15. Long-term anti-arthritic and anti-osteoporotic effects of raloxifene in established experimental postmenopausal polyarthritis. C Jochems M Lagerquist C Hakansson C Ohlsson H Carlsten, Clin Exp Immunol 2008 152 593 597 10.1111/j.1365-2249.2008.03660.x 18435803
16. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JE Rossouw GL Anderson RL Prentice AZ LaCroix C Kooperberg ML Stefanick RD Jackson SA Beresford BV Howard KC Johnson,, et al. Jama 2002 288 321 333 10.1001/jama.288.3.321 12117397
17. Breast cancer and hormone-replacement therapy in the Million Women Study. V Beral, Lancet 2003 362 419 427 10.1016/S0140-6736(03)14596-5 12927427
18. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. GL Anderson M Limacher AR Assaf T Bassford SA Beresford H Black D Bonds R Brunner R Brzyski B Caan,, et al. Jama 2004 291 1701 1712 10.1001/jama.291.14.1701 15082697
19. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. P Olofsson J Holmberg J Tordsson S Lu B Akerstrom R Holmdahl, Nat Genet 2003 33 25 32 10.1038/ng1058 12461526
20. Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. M Hultqvist P Olofsson J Holmberg BT Backstrom J Tordsson R Holmdahl, Proc Natl Acad Sci USA 2004 101 12646 12651 10.1073/pnas.0403831101 15310853
21. Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species. KA Gelderman M Hultqvist A Pizzolla M Zhao KS Nandakumar R Mattsson R Holmdahl, J Clin Invest 2007 117 3020 3028 10.1172/JCI31935 17909630
22. A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity. LM Olsson AK Lindqvist H Kallberg L Padyukov H Burkhardt L Alfredsson L Klareskog R Holmdahl, Arthritis Res Ther 2007 9 98 10.1186/ar2299 17897462
23. Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation. C Jochems U Islander M Erlandsson M Verdrengh C Ohlsson H Carlsten, Arthritis Res Ther 2005 7 837 843 10.1186/ar1753 15987485
24. A multicenter cross sectional study on bone mineral density in rheumatoid arthritis. Italian Study Group on Bone Mass in Rheumatoid Arthritis. L Sinigaglia A Nervetti Q Mela G Bianchi A Del Puente O Di Munno B Frediani F Cantatore R Pellerito S Bartolone,, et al. J Rheumatol 2000 27 2582 2589 11093437
25. Radiographic joint destruction in postmenopausal rheumatoid arthritis is strongly associated with generalised osteoporosis. H Forsblad D'Elia A Larsen E Waltbrand G Kvist D Mellstrom T Saxne C Ohlsson E Nordborg H Carlsten, Ann Rheum Dis 2003 62 617 623 12810422
26. Homologous type II collagen induces chronic and progressive arthritis in mice. R Holmdahl L Jansson E Larsson K Rubin L Klareskog, Arthritis Rheum 1986 29 106 113 10.1002/art.1780290114 3947407
27. Effects of raloxifene, a selective estrogen receptor modulator, on thymus, T cell reactivity, and inflammation in mice. MC Erlandsson E Gomori M Taube H Carlsten, Cell Immunol 2000 205 103 109 10.1006/cimm.2000.1719 11104582
28. Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in mice. MC Erlandsson CA Jonsson MK Lindberg C Ohlsson H Carlsten, J Endocrinol 2002 175 319 327 10.1677/joe.0.1750319 12429030
29. Comparative effects of estrogen and raloxifene on B lymphopoiesis and bone loss induced by sex steroid deficiency in mice. Y Onoe C Miyaura M Ito H Ohta S Nozawa T Suda, J Bone Miner Res 2000 15 541 549 10.1359/jbmr.2000.15.3. 541 10750569
30. Tamoxifen and the Rafoxifene analog LY117018: their effects on arachidonic acid release from cells in culture and on prostaglandin I2 production by rat liver cells. L Levine, BMC Cancer 2004 4 49 10.1186/1471-2407-4-49 15310397
31. Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice. SH Windahl O Vidal G Andersson JA Gustafsson C Ohlsson, J Clin Invest 1999 104 895 901 10.1172/JCI6730 10510330
32. Histopathological and serological progression of experimental Staphylococcus aureus arthritis. T Bremell A Abdelnour A Tarkowski, Infect Immun 1992 60 2976 2985 1612762
33. Functional discrimination between interleukin 6 and interleukin 1. M Helle L Boeije LA Aarden, Eur J Immunol 1988 18 1535 1540 10.1002/eji.1830181010 3263920
34. In vivo activation of gene transcription via oestrogen response elements by a raloxifene analogue. C Engdahl C Jochems JA Gustafsson PT van der Saag H Carlsten MK Lagerquist, J Endocrinol 2009 203 349 356 10.1677/JOE-09-0012 19752149
35. The effect of raloxifene on the uterine weight response in immature mice exposed to 17beta-estradiol, 1,1,1-trichloro-2, 2-bis(p-chlorophenyl)ethane, and methoxychlor. JH Al-Jamal NH Dubin, Am J Obstet Gynecol 2000 182 1099 1102 10.1067/mob.2000.105407 10819839
36. Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. LJ Black M Sato ER Rowley DE Magee A Bekele DC Williams GJ Cullinan R Bendele RF Kauffman WR Bensch,, et al. J Clin Invest 1994 93 63 69 10.1172/JCI116985 8282823
37. Advantages of raloxifene over alendronate or estrogen on nonreproductive and reproductive tissues in the long-term dosing of ovariectomized rats. M Sato HU Bryant P Iversen J Helterbrand F Smietana K Bemis R Higgs CH Turner I Owan Y Takano DB Burr, J Pharmacol Exp Ther 1996 279 298 305 8859007 (Pubitemid 27166925)
38. Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. M Sato MK Rippy HU Bryant, Faseb J 1996 10 905 912 8666168 (Pubitemid 26184169)
39. Antiproliferative and proapoptotic effects of raloxifene on uterine leiomyomas in postmenopausal women. S Palomba F Orio T Russo A Falbo A Tolino G Lombardi V Cimini F Zullo, Fertil Steril 2005 84 154 161 10.1016/j.fertnstert. 2004.12.058 16009171
40. Oestrogen exhibits type II collagen protective effects and attenuates collagen-induced arthritis in rats. RH Nielsen C Christiansen M Stolina MA Karsdal, Clin Exp Immunol 2008 152 21 27 10.1111/j.1365-2249.2008.03594.x 18241229
41. The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. SR Cummings S Eckert KA Krueger D Grady TJ Powles JA Cauley L Norton T Nickelsen NH Bjarnason M Morrow,, et al. Jama 1999 281 2189 2197 10.1001/jama.281.23.2189 10376571
42. Amelioration of Collagen-Induced Arthritis and Immune-Associated Bone Loss Through Signaling via Estrogen Receptor. C Engdahl C Jochems SH Windahl AE Börjesson C Ohlsson H Carlsten MK Lagerquist, Arthritis and Rheumatism 2010 62 2 524 33 20112355
43. Targeting IL-6 in the treatment of inflammatory and autoimmune diseases. C Ding F Cicuttini J Li G Jones, Expert Opin Investig Drugs 2009 18 1457 1466 10.1517/13543780903203789 19715447
44. Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo. R Axmann C Bohm G Kronke J Zwerina J Smolen G Schett, Arthritis Rheum 2009 60 2747 2756 10.1002/art.24781 19714627