The selective serotonin reuptake inhibitor citalopram decreases human immunodeficiency virus receptor and coreceptor expression in immune cells

Biological Psychiatry

Volumn 80, Issue 1, 2016, Pages 33-39

  Greeson, Jeffrey M ^a   Gettes, David R ^a   Spitsin, Sergei ^c   Dubé, Benoit ^a   Benton, Tami D ^a,c   Lynch, Kevin G ^a   Douglas, Steven D ^a,c   Evans, Dwight L ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

CCR5; CD4; CXCR4; Depression; HIV; SSRI

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; CITALOPRAM; INTERLEUKIN 2; MESSENGER RNA; PHYTOHEMAGGLUTININ; RNA; VIRUS RECEPTOR; CCR5 PROTEIN, HUMAN; CHEMOKINE RECEPTOR CXCR4; CXCR4 PROTEIN, HUMAN; SEROTONIN UPTAKE INHIBITOR;

ADULT; AFRICAN AMERICAN; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOWN REGULATION; EX VIVO STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCOMPETENT CELL; INFECTION SENSITIVITY; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; ADOLESCENT; DEPRESSIVE DISORDER; DRUG EFFECTS; HIV INFECTIONS; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIGENS, CD4; CITALOPRAM; DEPRESSIVE DISORDER; DOWN-REGULATION; FEMALE; HIV INFECTIONS; HUMANS; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MALE; MIDDLE AGED; MONOCYTES; RECEPTORS, CCR5; RECEPTORS, CXCR4; SEROTONIN UPTAKE INHIBITORS; YOUNG ADULT;

EID: 84951851495     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2015.11.003     Document Type: Article

References (73)

1. D.K. Male, J. Brostoff, D. Roth, and I. Roitt Immunology 8th ed. 2013 Saunders Philadelphia
2. C.A. Janeway Jr. The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation Annu Rev Immunol 10 1992 645 674
3. D. Gibbings, and A.D. Befus CD4 and CD8: An inside-out coreceptor model for innate immune cells J Leukoc Biol 86 2009 251 259
4. S. Lucas, and A.M. Nelson HIV and the spectrum of human disease J Pathol 235 2015 229 241
5. K.L. Jones, J.J. Maguire, and A.P. Davenport Chemokine receptor CCR5: From AIDS to atherosclerosis Br J Pharmacol 162 2011 1453 1469
6. Y. Doring, L. Pawig, C. Weber, and H. Noels The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease Front Physiol 5 2014 212
7. S. Hong, and W.A. Banks Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications Brain Behav Immun 45 2015 1 12
8. E.A. Berger, P.M. Murphy, and J.M. Farber Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease Annu Rev Immunol 17 1999 657 700
9. G. Alkhatib, and E.A. Berger HIV coreceptors: From discovery and designation to new paradigms and promise Eur J Med Res 12 2007 375 384
10. G. d'Ettorre, M. Paiardini, G. Ceccarelli, G. Silvestri, and V. Vullo HIV-associated immune activation: from bench to bedside AIDS Res Hum Retroviruses 27 2011 355 364
11. R. Rajasuriar, G. Khoury, A. Kamarulzaman, M.A. French, P.U. Cameron, and S.R. Lewin Persistent immune activation in chronic HIV infection: Do any interventions work? AIDS 27 2013 1199 1208
12. R. Mossner, and K.P. Lesch Role of serotonin in the immune system and in neuroimmune interactions Brain Behav Immun 12 1998 249 271
13. K. Hellstrand, and S. Hermodsson Role of serotonin in the regulation of human natural killer cell cytotoxicity J Immunol 139 1987 869 875
14. K. Hellstrand, and S. Hermodsson Enhancement of human natural killer cell cytotoxicity by serotonin: Role of non-T/CD16+ NK cells, accessory monocytes, and 5-HT1A receptors Cell Immunol 127 1990 199 214
15. T.M. Aune, H.W. Golden, and K.M. McGrath Inhibitors of serotonin synthesis and antagonists of serotonin 1A receptors inhibit T lymphocyte function in vitro and cell-mediated immunity in vivo J Immunol 153 1994 489 498
16. B. Hofmann, P. Nishanian, T. Nguyen, M. Liu, and J.L. Fahey Restoration of T-cell function in HIV infection by reduction of intracellular cAMP levels with adenosine analogues AIDS 7 1993 659 664
17. B. Hofmann, P. Afzelius, J. Iversen, G. Kronborg, P. Aabech, T. Benfield, and et al. Buspirone, a serotonin receptor agonist, increases CD4 T-cell counts and modulates the immune system in HIV-seropositive subjects AIDS 10 1996 1339 1347
18. J. Eugen-Olsen, P. Afzelius, L. Andresen, J. Iversen, G. Kronborg, P. Aabech, and et al. Serotonin modulates immune function in T cells from HIV-seropositive subjects Clin Immunol Immunopathol 84 1997 115 121
19. J. Gordon, and N.M. Barnes Lymphocytes transport serotonin and dopamine: Agony or ecstasy? Trends Immunol 24 2003 438 443
20. P.J. O'Connell, X. Wang, M. Leon-Ponte, C. Griffiths, S.C. Pingle, and G.P. Ahern A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells Blood 107 2006 1010 1017
21. D.L. Evans, K.G. Lynch, T. Benton, B. Dube, D.R. Gettes, N.B. Tustin, and et al. Selective serotonin reuptake inhibitor and substance P antagonist enhancement of natural killer cell innate immunity in human immunodeficiency virus/acquired immunodeficiency syndrome Biol Psychiatry 63 2008 899 905
22. T. Benton, K. Lynch, B. Dube, D.R. Gettes, N.B. Tustin, J. Ping Lai, and et al. Selective serotonin reuptake inhibitor suppression of HIV infectivity and replication Psychosom Med 72 2010 925 932
23. M. Irwin, T.L. Smith, and J.C. Gillin Low natural-killer cytotoxicity in major depression Life Sci 41 1987 2127 2133
24. S.J. Schleifer, S.E. Keller, R.N. Bond, J. Cohen, and M. Stein Major depressive disorder and immunity. Role of age, sex, severity, and hospitalization Arch Gen Psychiatry 46 1989 81 87
25. M. Irwin, T. Patterson, T.L. Smith, C. Caldwell, S.A. Brown, J.C. Gillin, and et al. Reduction of immune function in life stress and depression Biol Psychiatry 27 1990 22 30
26. M. Irwin, C. Caldwell, T.L. Smith, S. Brown, M.A. Schuckit, and J.C. Gillin Major depressive disorder, alcoholism, and reduced natural-killer-cell cytotoxicity - role of severity of depressive symptoms and alcohol-consumption Arch Gen Psychiatry 47 1990 713 719
27. D.L. Evans, J.D. Folds, J.M. Petitto, R.N. Golden, C.A. Pedersen, M. Corrigan, and et al. Circulating natural killer cell phenotypes in men and women with major depression. Relation to cytotoxic activity and severity of depression Arch Gen Psychiatry 49 1992 388 395
28. C.L. Raison, and A.H. Miller The neuroimmunology of stress and depression Semin Clin Neuropsychiatry 6 2001 277 294
29. J.K. Kiecolt-Glaser, and R. Glaser Depression and immune function: Central pathways to morbidity and mortality J Psychosom Res 53 2002 873 876
30. C.L. Raison, L. Capuron, and A.H. Miller Cytokines sing the blues: Inflammation and the pathogenesis of depression Trends Immunol 27 2006 24 31
31. S.E. Sephton, H.C. Kraemer, E. Neri, D.P. Stites, I. Weissbecker, and D. Spiegel Improving methods of assessing natural killer cell cytotoxicity Int J Methods Psychiatr Res 15 2006 12 21
32. M.R. Irwin, and A.H. Miller Depressive disorders and immunity: 20 years of progress and discovery Brain Behav Immun 21 2007 374 383
33. J. Blume, S.D. Douglas, and D.L. Evans Immune suppression and immune activation in depression Brain Behav Immun 25 2011 221 229
34. J.H. Burack, D.C. Barrett, R.D. Stall, M.A. Chesney, M.L. Ekstrand, and T.J. Coates Depressive symptoms and CD4 lymphocyte decline among HIV-infected men JAMA 270 1993 2568 2573
35. T.L. Patterson, W.S. Shaw, S.J. Semple, M. Cherner, J.A. McCutchan, J.H. Atkinson, and et al. Relationship of psychosocial factors to HIV disease progression Ann Behav Med 18 1996 30 39
36. K. Page-Shafer, G.N. Delorenze, W.A. Satariano, and W. Winkelstein Jr Comorbidity and survival in HIV-infected men in the San Francisco Men's Health Survey Ann Epidemiol 6 1996 420 430
37. T.J. Mayne, E. Vittinghoff, M.A. Chesney, D.C. Barrett, and T.J. Coates Depressive affect and survival among gay and bisexual men infected with HIV Arch Intern Med 156 1996 2233 2238
38. C.G. Lyketsos, D.R. Hoover, M. Guccione, M.A. Dew, J.E. Wesch, E.G. Bing, and et al. Changes in depressive symptoms as AIDS develops. The Multicenter AIDS Cohort Study Am J Psychiatry 153 1996 1430 1437
39. J. Leserman, E.D. Jackson, J.M. Petitto, R.N. Golden, S.G. Silva, D.O. Perkins, and et al. Progression to AIDS: The effects of stress, depressive symptoms, and social support Psychosom Med 61 1999 397 406
40. J. Leserman, J.M. Petitto, R.N. Golden, B.N. Gaynes, H. Gu, D.O. Perkins, and et al. Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS Am J Psychiatry 157 2000 1221 1228
41. J.R. Ickovics, M.E. Hamburger, D. Vlahov, E.E. Schoenbaum, P. Schuman, R.J. Boland, and et al. Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: Longitudinal analysis from the HIV Epidemiology Research Study JAMA 285 2001 1466 1474
42. J. Leserman, J.M. Petitto, H. Gu, B.N. Gaynes, J. Barroso, R.N. Golden, and et al. Progression to AIDS, a clinical AIDS condition and mortality: Psychosocial and physiological predictors Psychol Med 32 2002 1059 1073
43. D.L. Evans, T.R. Ten Have, S.D. Douglas, D.R. Gettes, M. Morrison, M.S. Chiappini, and et al. Association of depression with viral load, CD8 T lymphocytes, and natural killer cells in women with HIV infection Am J Psychiatry 159 2002 1752 1759
44. J. Leserman HIV disease progression: Depression, stress, and possible mechanisms Biol Psychiatry 54 2003 295 306
45. D.L. Evans, D.S. Charney, L. Lewis, R.N. Golden, J.M. Gorman, K.R. Krishnan, and et al. Mood disorders in the medically ill: Scientific review and recommendations Biol Psychiatry 58 2005 175 189
46. J. Leserman Role of depression, stress, and trauma in HIV disease progression Psychosom Med 70 2008 539 545
47. L.R. Temoshok, R.L. Wald, S. Synowski, and A. Garzino-Demo Coping as a multisystem construct associated with pathways mediating HIV-relevant immune function and disease progression Psychosom Med 70 2008 555 561
48. G. Ironson, C. O'Cleirigh, M. Kumar, L. Kaplan, E. Balbin, C.B. Kelsch, and et al. Psychosocial and neurohormonal predictors of HIV disease progression (CD4 cells and viral load): A 4 year prospective study AIDS Behav 19 2015 1388 1397
49. D.O. Perkins, R.A. Stern, R.N. Golden, C. Murphy, D. Naftolowitz, and D.L. Evans Mood disorders in HIV infection: Prevalence and risk factors in a nonepicenter of the AIDS epidemic Am J Psychiatry 151 1994 233 236
50. M. Hamilton Development of a rating scale for primary depressive illness Br J Soc Clin Psychol 6 1967 278 296
51. N.F. Hassan, D.E. Campbell, and S.D. Douglas Purification of human monocytes on gelatin-coated surfaces J Immunol Methods 95 1986 273 276
52. M. Gutierrez, and W. Abramowitz Steady-state pharmacokinetics of citalopram in young and elderly subjects Pharmacotherapy 20 2000 1441 1447
53. S.R. Bareggi, L. Bianchi, R. Cavallaro, M. Gervasoni, F. Siliprandi, and L. Bellodi Citalopram concentrations and response in obsessive-compulsive disorder. Preliminary results CNS Drugs 18 2004 329 335
54. B.A. Castro, C.D. Weiss, L.D. Wiviott, and J.A. Levy Optimal conditions for recovery of the human immunodeficiency virus from peripheral blood mononuclear cells J Clin Microbiol 26 1988 2371 2376
55. M.M. Manak, D.A. Moshkoff, L.T. Nguyen, J. Meshki, P. Tebas, F. Tuluc, and et al. Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals AIDS 24 2010 2789 2796
56. S. Spitsin, N.B. Tustin, E. Riedel, R. Tustin 3rd, J.B. Murray, L.M. Peck, and et al. Programmed death 1 receptor changes ex vivo in HIV-infected adults following initiation of highly active antiretroviral therapy Clin Vaccine Immunol 19 2012 752 756
57. S. Spitsin, K.E. Stevens, and S.D. Douglas Expression of substance P, neurokinin-1 receptor and immune markers in the brains of individuals with HIV-associated neuropathology J Neurol Sci 334 2013 18 23
58. D. Chege, Y. Chai, S. Huibner, L. McKinnon, C. Wachihi, M. Kimani, and et al. Evaluation of a quantitative real-time PCR assay to measure HIV-specific mucosal CD8+ T cell responses in the cervix PLoS One 5 2010 e13077
59. B. Maneglier, G.J. Guillemin, P. Clayette, C. Rogez-Kreuz, B.J. Brew, D. Dormont, and et al. Serotonin decreases HIV-1 replication in primary cultures of human macrophages through 5-HT(1A) receptors Br J Pharmacol 154 2008 174 182
60. S.L. Letendre, J. Marquie-Beck, R.J. Ellis, S.P. Woods, B. Best, D.B. Clifford, and et al. The role of cohort studies in drug development: Clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system J Neuroimmune Pharmacol 2 2007 120 127
61. M.R. Irwin, M.J. Levin, M.L. Laudenslager, R. Olmstead, A. Lucko, N. Lang, and et al. Varicella zoster virus-specific immune responses to a herpes zoster vaccine in elderly recipients with major depression and the impact of antidepressant medications Clin Infect Dis 56 2013 1085 1093
62. M.R. Irwin, M.J. Levin, C. Carrillo, R. Olmstead, A. Lucko, N. Lang, and et al. Major depressive disorder and immunity to varicella-zoster virus in the elderly Brain Behav Immun 25 2011 759 766
63. D. Liu, Z. Wang, S. Liu, F. Wang, S. Zhao, and A. Hao Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells Neuropharmacology 61 2011 592 599
64. R.J. Tynan, J. Weidenhofer, M. Hinwood, M.J. Cairns, T.A. Day, and F.R. Walker A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia Brain Behav Immun 26 2012 469 479
65. A.M. Kumar, J.B. Fernandez, I. Borodowsky, L. Gonzalez, and M. Kumar HIV-1 infection and central monoamine neurotransmitters Am J Infect Dis 3 2007 177 183
66. A.W. Ansari, H. Heiken, M. Moenkemeyer, and R.E. Schmidt Dichotomous effects of C-C chemokines in HIV-1 pathogenesis Immunol Lett 110 2007 1 5
67. E.P. Zorrilla, L. Luborsky, J.R. McKay, R. Rosenthal, A. Houldin, A. Tax, and et al. The relationship of depression and stressors to immunological assays: A meta-analytic review Brain Behav Immun 15 2001 199 226
68. A.H. Miller, V. Maletic, and C.L. Raison Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression Biol Psychiatry 65 2009 732 741
69. A.H. Miller, E. Haroon, C.L. Raison, and J.C. Felger Cytokine targets in the brain: Impact on neurotransmitters and neurocircuits Depress Anxiety 30 2013 297 306
70. E. Cassol, L. Cassetta, C. Rizzi, M. Alfano, and G. Poli M1 and M2a polarization of human monocyte-derived macrophages inhibits HIV-1 replication by distinct mechanisms J Immunol 182 2009 6237 6246
71. J.M. Petitto, J.D. Folds, H. Ozer, D. Quade, and D.L. Evans Abnormal diurnal variation in circulating natural killer cell phenotypes and cytotoxic activity in major depression Am J Psychiatry 149 1992 694 696
72. D.L. Evans, J. Leserman, D.O. Perkins, R.A. Stern, C. Murphy, K. Tamul, and et al. Stress-associated reductions of cytotoxic T lymphocytes and natural killer cells in asymptomatic HIV infection Am J Psychiatry 152 1995 543 550
73. J. Leserman, J.M. Petitto, D.O. Perkins, J.D. Folds, R.N. Golden, and D.L. Evans Severe stress, depressive symptoms, and changes in lymphocyte subsets in human immunodeficiency virus-infected men. A 2-year follow-up study Arch Gen Psychiatry 54 1997 279 285