Risk Factors, Clinical Presentation, and Outcomes in Overdose with Acetaminophen Alone or with Combination Products Results from the Acute Liver Failure Study Group

Journal of Clinical Gastroenterology

Volumn 50, Issue 1, 2016, Pages 85-91

  Serper, Marina ^a   Wolf, Michael S ^b,c   Parikh, Nikhil A ^d   Tillman, Holly ^e   Lee, William M ^f   Ganger, Daniel R ^g  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b Health Literacy and Learning Program   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d ADVOCATE ILLINOIS MASONIC MEDICAL CENTER   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^g UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

combination analgesics; drug overdose; liver toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DIPHENHYDRAMINE; OPIATE; PARACETAMOL; DRUG COMBINATION; NARCOTIC ANALGESIC AGENT;

ACUTE LIVER FAILURE; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL FEATURE; COMORBIDITY; DEMOGRAPHY; DRUG OVERDOSE; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEART ARRHYTHMIA; HEMODIALYSIS; HEPATIC ENCEPHALOPATHY; HOSPITAL INFECTION; HUMAN; LABORATORY TEST; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK FACTOR; SEIZURE; TOXIC HEPATITIS; CHEMICALLY INDUCED; COMPARATIVE STUDY; DRUG COMBINATION; DRUG-INDUCED LIVER INJURY; FACTUAL DATABASE; LIVER FAILURE, ACUTE; MIDDLE AGED; PROGNOSIS; TIME FACTOR; YOUNG ADULT;

ACETAMINOPHEN; ADULT; ANALGESICS, OPIOID; DATABASES, FACTUAL; DIPHENHYDRAMINE; DRUG COMBINATIONS; DRUG OVERDOSE; DRUG-INDUCED LIVER INJURY; FEMALE; HUMANS; LIVER FAILURE, ACUTE; MALE; MIDDLE AGED; PROGNOSIS; RISK FACTORS; TIME FACTORS; YOUNG ADULT;

EID: 84951844170     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0000000000000378     Document Type: Article

References (29)

1. Ghany MG, Strader DB, Thomas DL, et al. American Association for the Study of Liver D. Diagnosis, management, and treatment of hepatitis C: An update. Hepatology. 2009;49: 1335-1374.
2. IMS Institute for Healthcare Informatics. The Use of Medicines in the United States: Review of 2011. Available at: Http://www.imshealth.com/ims/Global/Content/Insights/IMS%20Insti tute%20for%20Healthcare%20Informatics/IHII-Medicines-in-U.S-Report-2011.pdf. Accessed July 3, 2013.
3. Manthripragada AD, Zhou EH, Budnitz DS, et al. Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States. Pharmacoepidemiol Drug Saf. 2011;20:819-826.
4. Li C, Martin BC. Trends in emergency department visits attributable to acetaminophen overdoses in the United States: 1993-2007. Pharmacoepidemiol Drug Saf. 2011;20:810-818.
5. Bronstein AC, Spyker DA, Cantilena LR Jr, et al. 2009 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 27th Annual Report. Clin Toxicol. 2010;48:979-1178.
6. Ostapowicz G, Fontana RJ, Schiodt FV, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002;137:947-954.
7. Larson AM, Polson J, Fontana RJ, et al. Acetaminopheninduced acute liver failure: Results of a United States multicenter, prospective study. Hepatology. 2005;42:1364-1372.
8. Bower WA, Johns M, Margolis HS, et al. Population-based surveillance for acute liver failure. Am J Gastroenterol. 2007; 102:2459-2463.
9. Wolf MS, King J, Jacobson K, et al. Risk of unintentional overdose with non-prescription acetaminophen products. J Gen Intern Med. 2012;27:1587-1593.
10. King JP, Davis TC, Bailey SC, et al. Developing consumercentered, nonprescription drug labeling a study in acetaminophen. Am J Prev Med. 2011;40:593-598.
11. Fosnocht D, Taylor JR, Caravati EM. Emergency department patient knowledge concerning acetaminophen (paracetamol) in over-the-counter and prescription analgesics. Emerg Med J. 2008;25:213-216.
12. Stumpf JL, Skyles AJ, Alaniz C, et al. Knowledge of appropriate acetaminophen doses and potential toxicities in an adult clinic population. J Am Pharm Assoc (2003). 2007;47: 35-41.
13. Gokhale M, Martin BC. Prescription-acquired acetaminophen use and potential overuse patterns: 2001-2008. Pharmacoepidemiol Drug Saf. 2012;21:226-230.
14. Hodgman MJ, Garrard AR. A review of acetaminophen poisoning. Crit Care Clin. 2012;28:499-516.
15. Wang GS, Monte A, Bagdure D, et al. Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose. Pediatrics. 2011;127:e1077-e1080.
16. Schwartz EA, Hayes BD, Sarmiento KF. Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine. Ann Emerg Med. 2009;54:421-423.
17. Halcomb SE, Sivilotti ML, Goklaney A, et al. Pharmacokinetic effects of diphenhydramine or oxycodone in simulated acetaminophen overdose. Acad Emerg Med. 2005;12:169-172.
18. Milligan KR, Howe JP, McClean E, et al. Postoperative gastric emptying in outpatient anesthesia: The effect of opioid supplementation. J Clin Anesth. 1988;1:9-11.
19. Greiff JM, Rowbotham D. Pharmacokinetic drug interactions with gastrointestinal motility modifying agents. Clin Pharmacokinet. 1994;27:447-461.
20. Rollstin AD, Seifert SA. Acetaminophen/diphenhydramine overdose in profound hypothermia. Clin Toxicol. 2013;51: 50-53.
21. Polson J, Lee WM. AASLD position paper: The management of acute liver failure. Hepatology. 2005;41:1179-1197.
22. Ferenci P, Lockwood A, Mullen K, et al. Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: Final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology. 2002;35:716-721.
23. O'Grady JG, Alexander GJ, Hayllar KM, et al. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology. 1989;97:439-445.
24. Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with end-stage liver disease. Hepatology. 2001;33:464-470.
25. Bond GR, Ho M, Woodward RW. Trends in hepatic injury associated with unintentional overdose of paracetamol (Acetaminophen) in products with and without opioid: An analysis using the National Poison Data System of the American Association of Poison Control Centers, 2000-7. Drug Saf. 2012;35:149-157.
26. King JP, McCarthy DM, Serper M, et al. Variability in acetaminophen labeling practices: A missed opportunity to enhance patient safety. J Med Toxicol. 2015. [Epub ahead of print].
27. NCPDP Recommendations for Improved Prescription Container Labels for Medicines Containing Acetaminophen. Available at: Http://www.fda.gov/downloads/Drugs/DrugSaf ety/UCM266631.pdf. (Accessed May 8, 2013).
28. Hawton K, Bergen H, Simkin S, et al. Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: Interrupted time series analyses. BMJ. 2013;346:f403.
29. Bernal W, Maggs J, Willars C, et al. Arterial blood lactate as a prognostic marker in acute liver failure: Validation in 1000 patients. [abstract]. J Hepatol. 2013;58(S1):S12-S13.