Trends in emergency department visits attributable to acetaminophen overdoses in the United States: 1993-2007

Pharmacoepidemiology and Drug Safety

Volumn 20, Issue 8, 2011, Pages 810-818

  Li, Chenghui ^a   Martin, Bradley C ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Acetaminophen; Adverse event; Emergency department; Tylenol

Indexed keywords

PARACETAMOL;

ADOLESCENT; ADULT; AGED; ALCOHOL ABUSE; ALCOHOLISM; ARTICLE; BIVARIATE ANALYSIS; CHILD; CONFIDENCE INTERVAL; DRUG OVERDOSE; EMERGENCY WARD; FEMALE; GEOGRAPHIC DISTRIBUTION; HEALTH INSURANCE; HEALTH SURVEY; HOSPITAL ADMISSION; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; RACE; SCHOOL CHILD; TREND STUDY; UNITED STATES;

ACETAMINOPHEN; ADOLESCENT; ADULT; AGE FACTORS; AGED; ANALGESICS, NON-NARCOTIC; CHILD; CHILD, PRESCHOOL; EMERGENCY SERVICE, HOSPITAL; FEMALE; HEALTH CARE SURVEYS; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; OVERDOSE; UNITED STATES; YOUNG ADULT;

EID: 79960710666     PISSN: 10538569     EISSN: 10991557     Source Type: Journal    
DOI: 10.1002/pds.2103     Document Type: Article

References (35)

1. Paulose-Ram R, Hirsch R, Dillon C, Losonczy K, Cooper M, Ostchega Y. Prescription and non-prescription analgesic use among the US adult population: results from the third National Health and Nutrition Examination Survey (NHANES III). Pharmacoepidemiol Drug Saf 2003;12:315-326.
2. Paulose-Ram R, Hirsch R, Dillon C, Gu Q.Frequent monthly use of selected non-prescription and prescription non-narcotic analgesics among U.S. adults.Pharmacoepidemiol Drug Saf 2005;14:257-266.
3. Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA.Recent patterns of medication use in the ambulatory adult population of the United States: the Slone Survey.JAMA 2002;287(3):337-344.
4. Federal Food and Drug Administration.Joint Meeting of the Drug Safety and Risk Management Advisory Committee with the Anesthetic and Life Support Drugs Advisory Committee and the Nonprescription Drugs Advisory Committee: Meeting Announcement. Rockville, MD, 29-30 June 2009. Available at: [Accessed on 21 April 2010].
5. Chun LJ, Tong MJ, Busuttil RW, Hiatt JR.Acetaminophen hepatotoxity and acute liver failure.J Clin Gastroenterol 2009;43(4):342-349.
6. Larson AM, Polson J, Fontana RJ, et al.Acetaminophen-induced acute liver failure: results of a United States multicenter prospective study.Hepatology 2005;42:1364-1372.
7. Bower WA, Johns M, Margolis HS, Williams IT, Bell BP.Population-based surveillance for acute liver failure.Am J Gastroenterol 2007;102:2459-2463.
8. Federal Food and Drug Administration. Safety Concerns.Associated with Over-the-Counter Drug Products Containing Analgesics/Antipyretic Active Ingredients for Internal Use. Rockville, MD, 22 January 2004. Available at: 1901.pdf [Accessed on 21 April 2010].
9. Nourjah P, Ahmad RS, Karwoski C, Willy M.Estimates of acetaminophen (paracetamol)-associated overdoses in the United States.Pharmacoepidemiol Drug Saf 2006;15:398-405.
10. Schilling A, Corey R, Leonard M, Eghtesad B.Acetaminophen: old drug, new warnings.Cleve Clin J Med 2010;77(1):19-27.
11. Kuehn BM.FDA Focuses on drugs and liver damage: labeling and other changes for acetaminophen.JAMA 2009;302(4):369-371.
12. Prior MJ, Cooper K, Cummins P, Bowen D.Acetaminophen availability increases in Canada with no increase in the incidence of reports of inpatient hospitalizations with acetaminophen overdose and acute liver toxicity.Am J Ther 2004;11:443-452.
13. Myers RP, Leung Y, Shaheen AAM, Li B.Validation of ICD-9-CM/ICD-10 coding algorithm for the identification of patients with acetaminophen overdose and hepatotoxicity using administrative data.BMC Health Serv Res 2007;7:159. DOI:10.1186/1472-6963-7-159
14. Office of Management and Budget.Revisions to the Standards for the Classification of Federal Data on Race and Ethnicity. Washington, DC, 30 October 1997. Available at: [Accessed on 21 April 2010].
15. Pletcher MJ, Kertesz SG, Kohn MA, Gonzales R.Trends in opioid prescribing by race/ethnicity for patients seeking care in US emergency departments.JAMA 2008;299(1):70-778.
16. Schneider D, Appleton L, McLemore T.A reason for visit classification for ambulatory care. National Center for Health Statistics.Vital Health Stat 1979;2(78):1-63. Available at: [Accessed on 20 April 2010].
17. United States Department of Health and Human Services (US DHHS), Centers for Disease Control and Prevention (CDC), National Center for Health Statistics (NCHS), Bridged-Race Population Estimates, United States July 1st resident population by state, county, age, sex, bridged-race, and Hispanic origin, compiled from 1990-1999 bridged-race intercensal population estimates and 2000-2008 (Vintage 2008) bridged-race postcensal population estimates, on CDC WONDER On-line Database. Available at: [Accessed on 21 April 2010].
18. Grant BF, Dawson DA, Stinson FS, Chou SP, Dufour MC, Pickering RP.The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002.Drug Alcohol Depend 2004;74(3):223-234.
19. 2007 National Hospital Ambulatory Medical Care Survey Micro-data File Documentation. Available at: [Accessed on 21 April 2010].
20. Willy M, Kelly JP, Nourjah P, Kaufman DW, Budnitz DS, Staffa J.Emergency department visits attributed to selected analgesics, United States, 2004-2005.Pharmacoepidemiol Drug Saf 2009;18:188-195.
21. McCaig LF, McCaig L, Burt CW.Poisoning-related visits to emergency departments in the United States, 1993-1996.Clin Toxicol 1999;37(7):817-826.
22. Vernacchio L, Kelly JP, Kaufman DW, Mitchell AA.Cough and cold medication use by US children, 1999-2006: results from the Slone Survey.Pediatrics 2008;122;e323-e329.
23. Drug Abuse Warning Network (DAWN).Disposition of Emergency Department Visits for Drug-Related Suicide Attempts by Adolescents: 2004. The New DAWN Report, Issue 6, 2006.
24. Kelly JP, Cook SF, Kaufman DW, Anderson T, Rosenberg L, Mitchell AA.Prevalence and characteristics of opioid use in the US adult population.Pain 2008;13:507-513.
25. Substance Abuse and Mental Health Services Administration, Office of Applied Studies.Drug Abuse Warning Network, 2003: Interim National Estimates of Drug-Related Emergency Department Visits. DAWN Series D-26, DHHS Publication No. (SMA) 04-3972. Rockville, MD, 2004.
26. Substance Abuse and Mental Health Services Administration, Office of Applied Studies.Drug Abuse Warning Network, 2004: Selected Tables of National Estimates of Drug-Related Emergency Department Visits. Rockville, MD, 2009.
27. Substance Abuse and Mental Health Services Administration, Office of Applied Studies.Drug Abuse Warning Network, 2005: Selected Tables of National Estimates of Drug-Related Emergency Department Visits. Rockville, MD, 2009.
28. Substance Abuse and Mental Health Services Administration, Office of Applied Studies.Drug Abuse Warning Network, 2006: National Estimates of Drug-Related Emergency Department Visits. DAWN Series D-30, DHHS Publication No. (SMA) 08-4339, Rockville, MD, 2008.
29. Curtis LH, Stoddard J, Radeva JI, et al.Geographic variation in the prescription of Schedule II opioid analgesics among outpatients in the United States.Health Serv Res 2006;41(3): Part I837-855.
30. Zerzan JT, Morden NE, Soumerai S, et al.Trends and geographic variation of opiate medication use in state Medicaid fee-for-service programs, 1996-2002.Med Care 2006;44(11):1005-1010.
31. Kumar S, Rex DK.Failure of physicians to recognize acetaminophen hepatotoxicity in chronic alcoholics.Arch Intern Med 1991;151:1189-1191.
32. Quallich LG, Brown W, Shehab TM, Fontana RJ.Management of acetaminophen hepatotoxicity: a survey of practicing physicians.J Clin Outcomes Manage 2001;8(6):25-32.
33. Fosnocht D, Talyor JR, Caravati EM.Emergency department patient knowledge concerning acetaminophen (paracetamol) in over-the-counter and prescription analgesics.Emerg Med J 2008;25:213-216. DOI:10.1136/emj.2007.053850
34. Cham E, Hall L, Ernst AA, Weiss SJ.Awareness and use of over-the-counter pain medications: A survey of emergency department patients.South Med J 2002;95(5):529-535.
35. Myers WC, Otto TA, Harris E, Diaco D, Moreno A.Acetaminophen overdose as a suicidal gesture: A survey of adolescents' knowledge of its potential for toxicity.J Am Acad Child Adolesc Psychiatry 1992;31(4):686-690.