Knowledge of appropriate acetaminophen doses and potential toxicities in an adult clinic population

Journal of the American Pharmacists Association

Volumn 47, Issue 1, 2007, Pages 35-41

  Stumpf, Janice L ^a,b   Skyles, Amy J ^b   Alaniz, Cesar ^c,d   Erickson, Steven R ^d  

^a Drug Information Service   (United States)

^b Investigational Drug Service   (United States)

^c Critical Care Medicine Unit   (United States)

^d UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Acetaminophen; Consumers; Hepatotoxicity; Patients; Surveys

Indexed keywords

ANALGESIC AGENT; PARACETAMOL;

ADULT; ARTICLE; CROSS-SECTIONAL STUDY; FEMALE; HEALTH EDUCATION; HUMAN; INFORMATION PROCESSING; KNOWLEDGE; MALE; MIDDLE AGED; PATIENT; PROSPECTIVE STUDY; QUESTIONNAIRE;

ACETAMINOPHEN; ADULT; ANALGESICS, NON-NARCOTIC; CROSS-SECTIONAL STUDIES; DATA COLLECTION; FEMALE; HEALTH EDUCATION; HUMANS; KNOWLEDGE; MALE; MIDDLE AGED; PATIENTS; PROSPECTIVE STUDIES; QUESTIONNAIRES;

EID: 33947518237     PISSN: 15443191     EISSN: 15443450     Source Type: Journal    
DOI: 10.1331/1544-3191.47.1.35.Stumpf     Document Type: Article

References (25)

1. Ostapowicz G, Fontana R, Schiodt FV, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002;137:947-54.
2. Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology. 2005;42:1364-72.
3. Lee WM. Drug-induced hepatotoxicity. N Engl J Med. 2003;349:474-85.
4. Whitcomb DC, Block GD. Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA. 1994;272:1845-50.
5. McEvoy GK, ed. AHFS drug information 2005. Bethesda, Md.: American Society of Health-System Pharmacists; 2005.
6. Tylenol product information page. 2005. McNeil Consumer & Specialty Pharmaceuticals Web site. Accessed at www.tylenol.com, January 18, 2006.
7. Simon HK, Weinkel DA. Over-the-counter medications: do parents give what they intend to give? Arch Pediatr Adolesc Med. 1997;151:654-6.
8. Linder N, Sirota L, Snapir A, et al. Parental knowledge of the treatment of fever in children. Isr Med Assoc J. 1999;1:158-60.
9. Barrett TW, Norton VC. Parental knowledge of different acetaminophen concentrations for infants and children. Acad Emerg Med. 2000;7:718-21.
10. Li SF, Lacher B, Crain EF. Acetaminophen and ibuprofen dosing by parents. Pediatr Emerg Care. 2000;16:394-7.
11. Myers WC, Otto TA, Harris E, et al. Acetaminophen overdose as a suicidal gesture: a survey of adolescents' knowledge of its potential for toxicity. J Am Acad Child Adolesc Psychiatry. 1992;31:686-90.
12. Gilbertson RJ, Harris E, Pandey SK, et al. Paracetamol use, availability, and knowledge of toxicity among British and American adolescents. Arch Dis Child. 1996;75:194-8.
13. Huott MA, Storrow AB. A survey of adolescents' knowledge regarding toxicity of over-the-counter medications. Acad Emerg Med. 1997;4:214-8.
14. Cham E, Hall L, Ernst AA, Weiss SJ. Awareness and use of over-the-counter pain medications: a survey of emergency department patients. South Med J. 2002;95:529-35.
15. Chen L, Schneider S, Wax P. Knowledge about acetaminophen toxicity among emergency department visitors. Vet Human Toxicol. 2002;44:370-3.
16. Voluntary acetaminophen labeling revisions include overdose warning. The Green Sheet. 2002(Sept 23):3-4.
17. Schiodt FV, Rochling FA, Casey DL, Lee WM. Acetaminophen toxicity in an urban county hospital. N Engl J Med. 1997;337:1112-7.
18. Heaton PC, Cluxton RJ Jr, Moomaw CJ. Acetaminophen overuse in the Ohio Medicaid population. J Am Pharm Assoc. 2003;43:680-4.
19. Zuckerman IH, Menis M, McNally DL, et al. Intervention for decreasing excessive acetaminophen use in Pennsylvania Medicaid recipients. Am J Health Syst Pharm. 2004;61:2410-4.
20. Safe use of over-the-counter pain relievers (analgesics) and fever reducers (antipyretics). January 22, 2004. Food and Drug Administration Web site. Accessed at www.fda.gov/cder/drug/analgesics/default.htm, January 18, 2006.
21. Acetaminophen hepatotoxicity and nonsteroidal anti-inflammatory drug (NSAID)-related gastrointestinal and renal toxicity. Letter to the state boards of pharmacy. January 22, 2004. Food and Drug Administration Center for Drug Evaluation and Research Web Site. Accessed at www.fda.gov/cder/drug/analgesics/ letter.htm, January 18, 2006.
22. Rumack BH. Acetaminophen misconceptions. Hepatology. 2004;40:10-5.
23. Zimmerman JH, Maddrey WC. Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. Hepatology. 1995;22:767-73.
24. Lee WM. Acetaminophen and the U.S. acute liver failure study group: Lowering the risks of hepatic failure. Hepatology 2004;40:6-9.
25. Quallich LG, Brown JW, Shehab TM, Fontana RJ. Management of acetaminophen hepatotoxicity: a survey of practicing physicians. J Clin Outcome Manage. 2001;8(6):25-32.