Cell Nucleus-Targeting Zwitterionic Carbon Dots

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Jung, Yun Kyung ^a   Shin, Eeseul ^a   Kim, Byeong Su ^a  

^a Ulsan National Institute of Science and Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; DOXORUBICIN; ION;

ANIMAL; CELL DEATH; CELL NUCLEUS; CELL PROLIFERATION; DRUG DELIVERY SYSTEM; DRUG EFFECTS; HELA CELL LINE; HUMAN; LUMINESCENCE; METABOLISM; NUDE MOUSE; SPECTROFLUOROMETRY; THERANOSTIC NANOMEDICINE; ULTRASTRUCTURE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; CARBON; CELL DEATH; CELL NUCLEUS; CELL PROLIFERATION; DOXORUBICIN; DRUG DELIVERY SYSTEMS; HELA CELLS; HUMANS; IONS; LUMINESCENCE; MICE, NUDE; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; THERANOSTIC NANOMEDICINE;

EID: 84951828912     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18807     Document Type: Article

References (45)

1. Oyelere, A. K., Chen, P. C., Huang, X., El-Sayed, I. H. & El-Sayed, M. A. Peptide-conjugated gold nanorods for nuclear targeting. Bioconjugate Chem. 18, 1490-1497 (2007).
2. Kuo, C.-W., Chueh, D.-Y., Singh, N., Chien, F.-C. & Chen, P. Targeted nuclear delivery using peptide-coated quantum dots. Bioconjugate Chem. 22, 1073-1080 (2011).
3. Jana, A. et al. Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol. Bioconjugate Chem. 24, 1828-1839 (2013).
4. Haag, R. & Kratz, F. Polymer therapeutics: Concepts and applications. Angew. Chem.-Int. Edit. 45, 1198-1215 (2006).
5. Kataoka, K., Harada, A. & Nagasaki, Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv. Drug Deliv. Rev. 47, 113-131 (2001).
6. Lee, S. et al. Hyperbranched double hydrophilic block copolymer micelles of poly (ethylene oxide) and polyglycerol for pH-responsive drug delivery. Biomacromolecules 13, 1190-1196 (2012).
7. Son, S., Shin, E. & Kim, B.-S. Light-responsive micelles of spiropyran initiated hyper-branched polyglycerol for smart drug delivery. Biomacromolecules 15, 628-634 (2014).
8. Medintz, I. L., Uyeda, H. T., Goldman, E. R. & Mattoussi, H. Quantum dot bioconjugates for imaging, labelling and sensing. Nat. Mater. 4, 435-446 (2005).
9. Bagalkot, V. et al. Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer. Nano Lett. 7, 3065-3070 (2007).
10. Savla, R., Taratula, O., Garbuzenko, O. & Minko, T. Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer. J. Control. Release 153, 16-22 (2011).
11. Zheng, X. T., Ananthanarayanan, A., Luo, K. Q. & Chen, P. Glowing graphene quantum dots and carbon dots: Properties, syntheses, and biological applications. Small 11, 1620-1636 (2015).
12. Sun, Y.-P. et al. Quantum-sized carbon dots for bright and colorful photoluminescence. J. Am. Chem. Soc. 128, 756-7757 (2006).
13. Liu, C. et al. Nano-carrier for gene delivery and bioimaging based on carbon dots with PEI-passivation enhanced fluorescence. Biomaterials 33, 3604-3613 (2012).
14. Kim, D., Choi, Y., Shin, E., Jung, Y. K. & Kim, B.-S. Sweet nanodot for biomedical imaging: carbon dot derived from xylitol. RSC Adv. 4, 23210-23213 (2014).
15. Choi, Y. et al. Highly biocompatible carbon nanodots for simultaneous bioimaging and targeted photodynamic therapy in vitro and in vivo. Adv. Funct. Mater. 24, 5781-5789 (2014).
16. Lee, H. U. et al. Photoluminescent carbon nanotags from harmful cyanobacteria for drug delivery and imaging in cancer cells. Sci. Rep. 4, 4665 (2014).
17. Lai, C.-W., Hsiao, Y.-H., Peng, Y.-K. & Chou, P.-T. Facile synthesis of highly emissive carbon dots from pyrolysis of glycerol; gram scale production of carbon dots/mSiO2 for cell imaging and drug release. J. Mater. Chem. 22, 14403-14409 (2012).
18. Mewada, A., Pandey, S., Thakur, M., Jadhav, D. & Sharon, M. Swarming carbon dots for folic acid mediated delivery of doxorubicin and biological imaging. J. Mater. Chem. B 2, 698-705 (2014).
19. Wei, J. et al. Simple one-step synthesis of water-soluble fluorescent carbon dots from waste paper. New J. Chem. 38, 906-909 (2014).
20. Huang, X. et al. Effect of injection routes on the biodistribution, clearance, and tumor uptake of carbon dots. ACS Nano 7, 5684-5693 (2013).
21. Pierrat, P. et al. Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers. Biomaterials 51, 290-302 (2015).
22. Gaal, E. V. B. et al. DNA nuclear targeting sequences for non-viral gene delivery. Pharm. Res. 28, 1707-1722 (2011).
23. Arvizo, R. R. et al. Effect of nanoparticle surface charge at the plasma membrane and beyond. Nano Lett. 10, 2543-2548 (2010).
24. Zhao, F., Zhao, Y., Chang, X., Chen, C. & Zhao, Y. Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials. Small 7, 1322-1337 (2011).
25. Zhou, N. et al. Elucidating the endocytosis, intracellular trafficking, and exocytosis of carbon dots in neural cells. RSC Adv. 4, 62086-62095 (2014).
26. Guo, S. et al. Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyeletrolyte. ACS Nano 4, 5505-5511 (2010).
27. Lawaczeck, R., Nandi, P. K. & Nicolau, C. Interaction of negatively charged liposomes with nuclear membranes: adsorption, lipid mixing and lysis of the vesicles. Biochim. Biophys. Acta-Biomembr. 903, 123-131 (1987).
28. Seksek, O. & Bolard, J. Nuclear pH gradient in mammalian cells revealed by laser microspectrofluorimetry. J. Cell Sci. 109, 257-262 (1996).
29. Mehiri, M. et al. Cellular entry and nuclear targeting by a highly anionic molecular umbrella. Bioconjugate Chem. 19, 1510-1513 (2008).
30. Breus, V. V., Heyes, C. D., Tron, K. & Nienhaus, G. U. Zwitterionic biocompatible quantum dots for wide pH stability and weak nonspecific binding to cells. ACS Nano 3, 2573-2580 (2009).
31. Park, J. et al. Compact and stable quantum dots with positive, negative, or zwitterionic surface: Specific cell interactions and nonspecific adsorptions by the surface charges. Adv. Funct. Mater. 21, 1558-1566 (2011).
32. Sun, M., Yang, L., Jose, P., Wang, L. & Zweit, J. Functionalization of quantum dots with multidentate zwitterionic ligands: impact on cellular interactions and cytotoxicity. J. Mater. Chem. B 1, 6137-6146 (2013).
33. Yuan, Y.-Y. et al. Surface charge switchable nanoparticles based on zwitterionic polymer for enhanced drug delivery to tumor. Adv. Mater. 24, 5476-5480 (2012).
34. Zhan, N., Palui, G., Safi, M., Ji, X. & Mattoussi, H. Multidentate zwitterionic ligands provide compact and highly biocompatible quantum dots. J. Am. Chem. Soc. 135, 13786-13795 (2013).
35. Cheng, L. et al. Polycation-b-polyzwitterion copolymer grafted luminescent carbon dots as a multifunctional platform for serumresistant gene delivery and bioimaging. ACS Appl. Mater. Inter. 6, 20487-20497 (2014).
36. Kim, S. et al. Anomalous behaviors of visible luminescence from graphene quantum dots: Interplay between size and shape. ACS Nano 6, 8203-8208 (2012).
37. Zhu, H., Zhang, W. & Yu, S. F. Realization of lasing emission from graphene quantum dots using titanium dioxide nanoparticles as light scatterers. Nanoscale 5, 1797-1802 (2013).
38. Qu, D. et al. Formation mechanism and optimization of highly luminescent N-doped graphene quantum dots. Sci. Rep. 4, 5294 (2014).
39. Mühlhäusser, P., Müller, E.-C., Otto, A. & Kutay, U. Multiple pathways contribute to nuclear import of core histones. EMBO rep. 2, 690-696 (2001).
40. Mosammaparst, N. et al. Nuclear import of histone H2A and H2B is mediated by a network of karyopherins. J. Cell. Biol. 153, 251-262 (2001).
41. Mosammaparst, N., Guo, Y., Shabanowitz, J., Hunt, D. F. & Pemberton, L. F. Pathways mediating the nuclear import of histones H3 and H4 in yeast. J. Biol. Chem. 277, 862-868 (2002).
42. Keck, K. M. & Pemberton, L. F. Histone chaperones link histone nuclear import and chromatin assembly. Biochim. Biophys. Acta-Gene Regul. Mech. 1819, 277-289 (2012).
43. Alvisi, G. et al. Nuclear import of HSV-1 DNA polymerase processivity factor UL42 is mediated by a C-terminally located bipartite nuclear localization signal. Biochemistry-US 47, 13764-13777 (2008).
44. Hurley, L. H. DNA and its associated processes as targets for cancer therapy. Nat. Rev. Cancer 2, 188-200 (2002).
45. Kim, J.-B. et al. Non-invasive detection of a small number of bioluminescent cancer cells in vivo. PLoS One 5, e9364 (2010).