Neuroimaging of HIV-associated cryptococcal meningitis: comparison of magnetic resonance imaging findings in patients with and without immune reconstitution

International Journal of STD and AIDS

Volumn 27, Issue 2, 2016, Pages 110-117

  Katchanov, Juri ^a   Branding, Gordian ^a   Jefferys, Laura ^a   Arastéh, Keikawus ^a   Stocker, Hartmut ^a   Siebert, Eberhard ^b  

^a Vivantes Auguste Viktoria Klinikum   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

AIDS; Cryptococcal meningitis; Cryptococcus neoformans; Europe; HIV; immune reconstitution; IRIS; location; magnetic resonance imaging; MRI; neuroimaging; opportunistic infection; radiological features; viral disease

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; GADOLINIUM CHELATE; ANTIFUNGAL AGENT; FLUCONAZOLE;

ADULT; ANTIVIRAL THERAPY; ARTICLE; BRAIN DAMAGE; BRAIN INFARCTION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CRYPTOCOCCAL MENINGITIS; DIAGNOSTIC TEST ACCURACY STUDY; GERMANY; HEALTH CENTER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS ASSOCIATED CRYPTOCOCCAL MENINGITIS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMAGE ANALYSIS; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNOCOMPROMIZED PATIENT; LACUNAR STROKE; MALE; MEDICAL HISTORY; MEDICAL RECORD REVIEW; MENINGITIS; MENINGOENCEPHALITIS; MIDDLE AGED; MORBIDITY; NEUROANATOMY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; PSEUDOCYST; RECURRENCE RISK; RETROSPECTIVE STUDY; VIRUS MENINGITIS; ADVERSE EFFECTS; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ARACHNOID CYST; COMPARATIVE STUDY; COMPLICATION; CRYPTOCOCCUS NEOFORMANS; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV INFECTIONS; IMMUNOCOMPROMISED PATIENT; ISOLATION AND PURIFICATION; MENINGITIS, CRYPTOCOCCAL; PATHOLOGY;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTI-HIV AGENTS; ANTIFUNGAL AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; ARACHNOID CYSTS; CRYPTOCOCCUS NEOFORMANS; FEMALE; FLUCONAZOLE; GERMANY; HIV INFECTIONS; HUMANS; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNOCOMPROMISED HOST; MAGNETIC RESONANCE IMAGING; MALE; MENINGITIS, CRYPTOCOCCAL; MIDDLE AGED; NEUROIMAGING;

EID: 84951807540     PISSN: 09564624     EISSN: 17581052     Source Type: Journal    
DOI: 10.1177/0956462415574633     Document Type: Article

References (21)

1. R.RajasinghamM.A.RolfesK.E.Birkenkamp. Cryptococcal meningitis treatment strategies in resource-limited settings: a cost-effectiveness analysis. PLoS Med2012; 9: e1001316–e1001316.
2. J.JarvisG.Meintjes. Cryptococcal meningitis – a neglected killer. S Afr Med J2011; 101: 244–245.
3. C.RotheD.J.SloanP.Goodson. A prospective longitudinal study of the clinical outcomes from cryptococcal meningitis following treatment induction with 800 mg oral fluconazole in Blantyre, Malawi. PLoS One2013; 8: e67311–e67311.
4. C.CharlierF.DromerC.Lévêque. French Cryptococcosis Study Group. Cryptococcal neuroradiological lesions correlate with severity during cryptococcal meningoencephalitis in HIV-positive patients in the HAART era. PLoS One2008; 3: e1950–e1950.
5. R.D.TienP.K.ChuJ.R.Hesselink. Intracranial cryptococcosis in immunocompromised patients: CT and MR findings in 29 cases. Am J Neuroradiol1991; 12: 283–289.
6. V.P.MathewsP.L.AloJ.D.Glass. AIDS-related CNS cryptococcosis: radiologic-pathologic correlation. Am J Neuroradiol1992; 13: 1477–1486.
7. C.F.AndreulaN.BurdiA.Carella. CNS cryptococcosis in AIDS: spectrum of MR findings. J Comput Assist Tomogr1993; 17: 438–441.
8. K.A.MiszkielM.A.Hall-CraggsR.F.Miller. The spectrum of MRI findings in CNS cryptococcosis in AIDS. Clin Radiol1996; 51: 842–850.
9. J.BerkefeldW.EnzensbergerH.Lanfermann. Cryptococcus meningoencephalitis in AIDS: parenchymal and meningeal forms. Neuroradiology1999; 41: 129–133.
10. S.A.3.ShelburneSA 3rdJ.DarcourtA.C.WhiteJr. The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy. Clin Infect Dis2005; 40: 1049–1052.
11. T.BicanicG.MeintjesK.Rebe. Immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis: a prospective study. J Acquir Immune Defic Syndr2009; 51: 130–134.
12. S.AntinoriA.RidolfoM.Fasan. AIDS-associated cryptococcosis: a comparison of epidemiology, clinical features and outcome in the pre- and post-HAART eras. Experience of a single centre in Italy. HIV Med2009; 10: 6–11.
13. J.KatchanovM.von KleistK.Arastéh. ‘Time-to-amphotericin B' in cryptococcal meningitis in a European low-prevalence setting: analysis of diagnostic delays. QJM2014; 107: 799–803.
14. Musubire AK, Boulware DR, Meya DB, et al. Diagnosis and management of cryptococcal relapse. J AIDS Clin Res 2013; Suppl 3. pii: S3–003
15. J.KatchanovU.ZimmermannG.Branding. Multiphasic and multifocal cryptococcal immune reconstitution inflammatory syndrome in an HIV-infected patient: interplay of infection and immunity. Int J Infect Dis2014; 18: 87–89.
16. M.D.KingC.A.PerlinoJ.Cinnamon. Paradoxical recurrent meningitis following therapy of cryptococcal meningitis: an immune reconstitution syndrome after initiation of highly active antiretroviral therapy. Int J STD AIDS2002; 13: 724–726.
17. A.M.CattelanM.TrevenzoliL.Sasset. Multiple cerebral cryptococcomas associated with immune reconstitution in HIV-1 infection. AIDS2004; 18: 349–351.
18. D.R.BoulwareS.C.BonhamD.B.Meya. Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent immune reconstitution inflammatory syndrome. J Infect Dis2010; 202: 962–970.
19. G.BretonD.SeilheanP.Cherin. Paradoxical intracranial cryptococcoma in a human immunodeficiency virus-infected man being treated with combination antiretroviral therapy. Am J Med2002; 113: 155–157.
20. M.J.PostM.M.ThurnherD.B.Clifford. CNS-immune reconstitution inflammatory syndrome in the setting of HIV infection, part 1: overview and discussion of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome and cryptococcal-immune reconstitution inflammatory syndrome. Am J Neuroradiol2013; 34: 1297–1307.
21. D.J.RiedelC.A.PardoJ.McArthur. Therapy insight: CNS manifestations of HIV-associated immune reconstitution inflammatory syndrome. Nat Clin Prac Neurol2006; 2: 557–565.21.