Secondary neurotransmitter deficiencies in epilepsy caused by voltage-gated sodium channelopathies: A potential treatment target?

Molecular Genetics and Metabolism

Volumn 117, Issue 1, 2016, Pages 42-48

  Horvath, Gabriella A ^a   Demos, Michelle ^a   Shyr, Casper ^a,b   Matthews, Allison ^a,b   Zhang, Linhua ^b   Race, Simone ^a   Stockler Ipsiroglu, Sylvia ^a   Van Allen, Margot I ^a   Mancarci, Ogan ^c   Toker, Lilah ^c   Pavlidis, Paul ^c   Ross, Colin J ^a   Wasserman, Wyeth W ^a,b   Trump, Natalie ^d   Heales, Simon ^e,f   Pope, Simon ^e   Helen Cross, J ^d   van Karnebeek, Clara D M ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^e National Hospital   (United Kingdom)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Channelopathy; Dopamine; Nav1.2; Nav1.6; SCN2A; SCN8A; Seizures; Serotonin; Therapy

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; 5 HYDROXYTRYPTOPHAN; 5 METHYLTETRAHYDROFOLIC ACID; ANTIBIOTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CANNABIDIOL; CARBIDOPA PLUS LEVODOPA; CLOBAZAM; ETHOSUXIMIDE; ETIRACETAM; FOLINIC ACID; HOMOVANILLIC ACID; IMMUNOGLOBULIN; LAMOTRIGINE; MESSENGER RNA; NEOPTERIN; PERAMPANEL; PHENOBARBITAL; PHENYTOIN; PRAMIPEXOLE; PREDNISOLONE; PYRIDOXAL 5 PHOSPHATE; RUFINAMIDE; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.6; STEROID; TETRAHYDROBIOPTERIN; TOPIRAMATE; VALPROIC ACID; VIGABATRIN; 5-METHYLTETRAHYDROFOLATE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; DOPAMINE RECEPTOR; SCN2A PROTEIN, HUMAN; SCN8A PROTEIN, HUMAN; SODIUM CHANNEL; TETRAHYDROFOLIC ACID DERIVATIVE;

ADD ON THERAPY; AMINO ACID SUBSTITUTION; ANTIBIOTIC THERAPY; ANTICONVULSANT THERAPY; ARTICLE; ATAXIA; AUTISM; BRAIN ATROPHY; BRAIN DISEASE; CASE REPORT; CEREBELLUM ATROPHY; CEREBROSPINAL FLUID ANALYSIS; CHILD; CYANOSIS; DISEASE DURATION; DISEASE EXACERBATION; DNA SEQUENCE; DRUG DOSE REDUCTION; DRUG RESISTANT EPILEPSY; DRUG TREATMENT FAILURE; DYSKINESIA; ELECTROENCEPHALOGRAM; EPILEPTIC STATE; EXON; EYE MOVEMENT; FEMALE; FRAMESHIFT MUTATION; GENE MUTATION; GENE SEQUENCE; GENETIC MODEL; HUMAN; HYPERSALIVATION; MALE; MENINGOENCEPHALITIS; MICROCEPHALY; MISSENSE MUTATION; MUSCLE HYPOTONIA; NEUROTRANSMISSION; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOPENIA; PATHOGENICITY; PATHOLOGIC FRACTURE; PRIORITY JOURNAL; SCHOOL CHILD; SIGNAL TRANSDUCTION; SLEEP DISORDER; SODIUM CHANNELOPATHY; STOP CODON; TONIC SEIZURE; TREATMENT RESPONSE; VOLTAGE GATED SODIUM CHANNELOPATHY; AUTISTIC DISORDER; CEREBROSPINAL FLUID; CHANNELOPATHIES; DEFICIENCY; EPILEPSY; EXOME; GENETICS; METABOLISM; SEIZURES;

AUTISTIC DISORDER; CHANNELOPATHIES; CHILD; DRUG RESISTANT EPILEPSY; EPILEPSY; EXOME; FEMALE; HOMOVANILLIC ACID; HUMANS; HYDROXYINDOLEACETIC ACID; MALE; MUSCLE HYPOTONIA; MUTATION, MISSENSE; NAV1.2 VOLTAGE-GATED SODIUM CHANNEL; NAV1.6 VOLTAGE-GATED SODIUM CHANNEL; NEUROTRANSMITTER AGENTS; RECEPTORS, DOPAMINE; SEIZURES; SEQUENCE ANALYSIS, DNA; SODIUM CHANNELS; TETRAHYDROFOLATES;

EID: 84951789025     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2015.11.008     Document Type: Article

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