Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study

EBioMedicine

Volumn 2, Issue 8, 2015, Pages 960-967

  Nezu, Tomohisa ^a   Hosomi, Naohisa ^a   Takahashi, Tetsuya ^a   Anno, Kumiko ^b   Aoki, Shiro ^a   Shimamoto, Akira ^b   Maruyama, Hirofumi ^a   Hayashi, Tomonori ^c   Matsumoto, Masayasu ^a   Tahara, Hidetoshi ^b  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c RADIATION EFFECTS RESEARCH FOUNDATION   (Japan)

Author keywords

Endothelial dysfunction; Telomere G tail lengths; Telomere lengths; White matter changes

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; BIOLOGICAL MARKER;

AGE; AGED; ARTICLE; ASSAY; BODY MASS; CARDIOVASCULAR RISK; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DISEASE SEVERITY; DYSLIPIDEMIA; ECHOGRAPHY; ENDOTHELIAL DYSFUNCTION; FEMALE; FLOW MEDIATED DILATION; FRAMINGHAM RISK SCORE; GENDER; HUMAN; HYBRIDIZATION PROTECTION ASSAY; HYPERTENSION; INFLAMMATION; KIDNEY DYSFUNCTION; LEUKOCYTE TOTAL TELOMERE LENGTH; MAJOR CLINICAL STUDY; MALE; NITROGLYCERIN MEDIATED VASODILATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TELOMERE G TAIL LENGTH; TELOMERE HOMEOSTASIS; TELOMERE SHORTENING; VASODILATATION; WHITE MATTER LESION; AGING; CARDIOVASCULAR DISEASE; LEUKOCYTE; METABOLISM; PATHOLOGY; RISK FACTOR; TELOMERE; VERY ELDERLY; WHITE MATTER;

AGED; AGED, 80 AND OVER; AGING; BIOMARKERS; CARDIOVASCULAR DISEASES; FEMALE; HUMANS; LEUKOCYTES; MALE; RISK FACTORS; TELOMERE; TELOMERE HOMEOSTASIS; WHITE MATTER;

EID: 84951573887     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2015.05.025     Document Type: Article

References (30)

1. Anno K., Hayashi A., Takahashi T., Mitsui Y., Ide T., Tahara H. Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells. Biochem. Biophys. Res. Commun. 2007, 353(4):926-932.
2. Bailey S.M., Cornforth M.N., Kurimasa A., Chen D.J., Goodwin E.H. Strand-specific postreplicative processing of mammalian telomeres. Science 2001, 293(5539):2462-2465.
3. Blackburn E.H. Switching and signaling at the telomere. Cell 2001, 106(6):661-673.
4. Brouilette S., Singh R.K., Thompson J.R., Goodall A.H., Samani N.J. White cell telomere length and risk of premature myocardial infarction. Arterioscler. Thromb. Vasc. Biol. 2003, 23(5):842-846.
5. Butt H.Z., Atturu G., London N.J., Sayers R.D., Bown M.J. Telomere length dynamics in vascular disease: a review. Eur. J. Vasc. Endovasc. Surg. 2010, 40(1):17-26.
6. D'Agostino R.B., Vasan R.S., Pencina M.J., et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 2008, 117(6):743-753.
7. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 2005, 19(18):2100-2110.
8. De Meyer T., Rietzschel E.R., De Buyzere M.L., Van Criekinge W., Bekaert S. Telomere length and cardiovascular aging: the means to the ends?. Ageing Res. Rev. 2011, 10(2):297-303.
9. Deanfield J.E., Halcox J.P., Rabelink T.J. Endothelial function and dysfunction: testing and clinical relevance. Circulation 2007, 115(10):1285-1295.
10. Demissie S., Levy D., Benjamin E.J., et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell 2006, 5(4):325-330.
11. Fazekas F., Chawluk J.B., Alavi A., Hurtig H.I., Zimmerman R.A. MR signal abnormalities at 1.5T in Alzheimer's dementia and normal aging. AJR Am. J. Roentgenol. 1987, 149(2):351-356.
12. Hirashio S., Nakashima A., Doi S., et al. Telomeric g-tail length and hospitalization for cardiovascular events in hemodialysis patients. Clin. J. Am. Soc. Nephrol. 2014, 9(12):2117-2122.
13. Hirose M., Abe-Hashimoto J., Ogura K., Tahara H., Ide T., Yoshimura T. A rapid, useful and quantitative method to measure telomerase activity by hybridization protection assay connected with a telomeric repeat amplification protocol. J. Cancer Res. Clin. Oncol. 1997, 123(6):337-344.
14. Hosomi N., Aoki S., Matsuo K., et al. Association of serum anti-periodontal pathogen antibody with ischemic stroke. Cerebrovasc. Dis. 2012, 34(5-6):385-392.
15. Hoth K.F., Tate D.F., Poppas A., et al. Endothelial function and white matter hyperintensities in older adults with cardiovascular disease. Stroke 2007, 38(2):308-312.
16. Iwamoto Y., Maruhashi T., Fujii Y., et al. Intima-media thickness of brachial artery, vascular function, and cardiovascular risk factors. Arterioscler. Thromb. Vasc. Biol. 2012, 32(9):2295-2303.
17. Khan S., Chuturgoon A.A., Naidoo D.P. Telomeres and atherosclerosis. Cardiovasc. J. Afr. 2012, 23(10):563-571.
18. Maruhashi T., Soga J., Fujimura N., et al. Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome. Circulation 2012, 126(5):598-603.
19. Matsuo S., Imai E., Horio M., et al. Revised equations for estimated GFR from serum creatinine in Japan. Am. J. Kidney Dis. 2009, 53(6):982-992.
20. Minamino T., Miyauchi H., Yoshida T., Ishida Y., Yoshida H., Komuro I. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 2002, 105(13):1541-1544.
21. Miwa K., Tanaka M., Okazaki S., et al. Chronic kidney disease is associated with dementia independent of cerebral small-vessel disease. Neurology 2014, 82(12):1051-1057.
22. Nakashima H., Ozono R., Suyama C., Sueda T., Kambe M., Oshima T. Telomere attrition in white blood cell correlating with cardiovascular damage. Hypertens. Res. 2004, 27(5):319-325.
23. Neumann-Haefelin T., Hoelig S., Berkefeld J., et al. Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke. Stroke 2006, 37(10):2463-2466.
24. Palumbo V., Boulanger J.M., Hill M.D., Inzitari D., Buchan A.M., Investigators C. Leukoaraiosis and intracerebral hemorrhage after thrombolysis in acute stroke. Neurology 2007, 68(13):1020-1024.
25. Pantoni L., Garcia J.H. Pathogenesis of leukoaraiosis: a review. Stroke 1997, 28(3):652-659.
26. Scheltens P., Barkhof F., Leys D., et al. A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J. Neurol. Sci. 1993, 114(1):7-12.
27. Tahara H., Kusunoki M., Yamanaka Y., Matsumura S., Ide T. G-tail telomere HPA: simple measurement of human single-stranded telomeric overhangs. Nat. Methods 2005, 2(11):829-831.
28. Tsai Y.C., Qi H., Liu L.F. Protection of DNA ends by telomeric 3' G-tail sequences. J. Biol. Chem. 2007, 282(26):18786-18792.
29. von Zglinicki T., Martin-Ruiz C.M. Telomeres as biomarkers for ageing and age-related diseases. Curr. Mol. Med. 2005, 5(2):197-203.
30. Wikgren M., Karlsson T., Söderlund H., et al. Shorter telomere length is linked to brain atrophy and white matter hyperintensities. Age Ageing 2014, 43(2):212-217.